Both Mitochondrial K-ATP Channel Opening and Sarcolemmal K-ATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats

Aim This study was performed to assess The effect of selective sarcolemmal adenosine tnphosphate (ATP)-sensitive K+ channel (K-ATP) inhibition and the mitochondnal K-ATP channel activation on ischemia and reperfusion (I/R)-induced arrhythmias in different gender of rats We compared the effect of a selective sarcolemmal K-TAP channel blocker HMR 1098, a selective mitochondrial K-ATP channel opener diazoxide, a nonselective K-ATP channel opener pinacidil, and the combination of pinacidil with HMR 1098 on the incidence and duration of ventricular arrhythmias in 2 groups anesthetized males (n = 31) and females (n = 31) Main Methods ischema and reperfusion was produced by occluding the left main coronary artery of Sprague-Dowley rats for 6 minutes followed by re-opening of the artery for 6 minutes Key Findings The arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats The combination of the pinacidil with HMR 1098 did not change the antiarrhythmic effect of pinacidil The duration of arrhythmas was shorter in females than that in the corresponding males Drug treatments were not effective in decreasing arrhythmias in female groups to the same extent as in the male group However, the mitochondrial K-ATP channel activation that is provided by the combination of pinacidil with HMR 1098 significantly decreased the total length of arrhythmias in females Significance Results of the current study indicate that both mitochondnal K-ATP channel activation and sarcolemmal K-ATP channel inhibition exert antiarrhythmic action in male rats The antiarrthythmic effect of pinacidil is not depend on the sarcolemmal K-ATP channel opening These results also indicate that K-ATP channel modulators show no discernable effect in female rats due to the already low incidence of arrhythmias in females

Dergi Adı JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
Dergi Cilt Bilgisi 15
Dergi Sayısı 4
Sayfalar 403 - 411
Yayın Yılı 2010
Eser Adı
[dc.title]
Both Mitochondrial K-ATP Channel Opening and Sarcolemmal K-ATP Channel Blockage Confer Protection Against Ischemia/Reperfusion-Induced Arrhythmia in Anesthetized Male Rats
Yazar
[dc.contributor.author]
Gonca, Ersoz
Yazar
[dc.contributor.author]
Bozdogan, Omer
Yayın Yılı
[dc.date.issued]
2010
Yayıncı
[dc.publisher]
SAGE PUBLICATIONS INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Aim This study was performed to assess The effect of selective sarcolemmal adenosine tnphosphate (ATP)-sensitive K+ channel (K-ATP) inhibition and the mitochondnal K-ATP channel activation on ischemia and reperfusion (I/R)-induced arrhythmias in different gender of rats We compared the effect of a selective sarcolemmal K-TAP channel blocker HMR 1098, a selective mitochondrial K-ATP channel opener diazoxide, a nonselective K-ATP channel opener pinacidil, and the combination of pinacidil with HMR 1098 on the incidence and duration of ventricular arrhythmias in 2 groups anesthetized males (n = 31) and females (n = 31) Main Methods ischema and reperfusion was produced by occluding the left main coronary artery of Sprague-Dowley rats for 6 minutes followed by re-opening of the artery for 6 minutes Key Findings The arrhythmia score and the duration of arrhythmias were significantly reduced by HMR 1098, diazoxide, and pinacidil in male rats The combination of the pinacidil with HMR 1098 did not change the antiarrhythmic effect of pinacidil The duration of arrhythmas was shorter in females than that in the corresponding males Drug treatments were not effective in decreasing arrhythmias in female groups to the same extent as in the male group However, the mitochondrial K-ATP channel activation that is provided by the combination of pinacidil with HMR 1098 significantly decreased the total length of arrhythmias in females Significance Results of the current study indicate that both mitochondnal K-ATP channel activation and sarcolemmal K-ATP channel inhibition exert antiarrhythmic action in male rats The antiarrthythmic effect of pinacidil is not depend on the sarcolemmal K-ATP channel opening These results also indicate that K-ATP channel modulators show no discernable effect in female rats due to the already low incidence of arrhythmias in females
Açıklama
[dc.description]
WOS: 000284303300012
Açıklama
[dc.description]
PubMed: 20693159
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
HMR 1098
Konu Başlıkları
[dc.subject]
diazoxide
Konu Başlıkları
[dc.subject]
pinacidil
Konu Başlıkları
[dc.subject]
K-ATP channel
Konu Başlıkları
[dc.subject]
ischemia reperfusion arrhythmia
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1074-2484
Sponsor YAYINCI
[dc.description.sponsorship]
Abant Izzet Baysal UniversityAbant Izzet Baysal University [BAP-2006 03 01 250]
Sponsor YAYINCI
[dc.description.sponsorship]
The authors disclosed receipt of the following financial support for the research and/or authorship of this article Research fund grant from Abant Izzet Baysal University (BAP-2006 03 01 250)
İlk Sayfa Sayısı
[dc.identifier.startpage]
403
Son Sayfa Sayısı
[dc.identifier.endpage]
411
Dergi Adı
[dc.relation.journal]
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
15
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1177/1074248410372925
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2171
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Şubat 2024 09:13
Google Kontrol
Tıklayınız
channel pinacidil arrhythmias effect sarcolemmal females duration combination activation selective significantly incidence indicate groups artery female minutes antiarrhythmic diazoxide opener mitochondrial inhibition reperfusion mitochondnal modulators extent treatments decreasing effective discernable already corresponding However opening current
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms