Assessment of QRS duration and presence of fragmented QRS in patients with Behcet's disease

Background QRS prolongation and the presence of QRS fragmentation in 12-lead ECG are associated with increased mortality and sudden cardiac death in the long term. In this study we aimed to assess QRS duration and fragmentation in patients with Behcet's disease (BD).Methods A total of 50 patients (mean age 42.7 +/- 12.0 years) previously diagnosed with BD were recruited. In addition, a control group consisting of 50 healthy people (mean age 39.4 +/- 12.5 years) was formed. The longest QRS duration was measured in surface 12-lead ECG and QRS complexes were evaluated in terms of fragmentation. Serum C-reactive protein levels were also obtained.Results QRS duration and corrected QT duration were significantly longer in patients with BD compared with controls (102.75 +/- 11.91 vs. 96.99 +/- 10.91 ms, P=0.007; 438.55 +/- 30.80 vs. 420.23 +/- 28.06 ms, P=0.003, respectively). Fragmented QRS (fQRS) pattern was more common in patients with BD than controls [n=27 (54%) vs. n=16 (32%), P=0.026]. Disease duration was longer in patients with BD with fQRS compared with those without (12.67 +/- 8.68 vs. 7.09 +/- 7.06 years, P=0.010). Furthermore, C-reactive protein level was higher in patients with BD with fQRS compared with those without (6.53 +/- 4.11 vs. 4.97 +/- 6.32 mg/dl, P=0.043). Correlation analysis revealed no association between disease duration and QRS duration (r=0.219, P=0.126).Conclusion QRS duration is greater and fQRS complexes are more frequent in patients with BD. These findings may indicate subclinical cardiac involvement in BD. Given the prognostic significance of ECG parameters, it is reasonable to evaluate patients with BD with prolonged and fQRS complexes more in detail such as late potentials in signal averaged ECG in terms of cardiac involvement.

Yazar Sayin, Muhammet R.
Akpinar, Ibrahim
Gursoy, Yusuf C.
Kiran, Sibel
Gudul, Naile E.
Karabag, Turgut
Koca, Rafet
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2122
Tek Biçim Adres 10.1097/MCA.0b013e328361a978
Konu Başlıkları Behcet's disease
fragmented QRS
QRS duration
subclinical cardiac involvement
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı CORONARY ARTERY DISEASE
Dergi Cilt Bilgisi 24
Dergi Sayısı 5
Sayfalar 398 - 403
Yayın Yılı 2013
Eser Adı
[dc.title]
Assessment of QRS duration and presence of fragmented QRS in patients with Behcet's disease
Yazar
[dc.contributor.author]
Sayin, Muhammet R.
Yazar
[dc.contributor.author]
Akpinar, Ibrahim
Yazar
[dc.contributor.author]
Gursoy, Yusuf C.
Yazar
[dc.contributor.author]
Kiran, Sibel
Yazar
[dc.contributor.author]
Gudul, Naile E.
Yazar
[dc.contributor.author]
Karabag, Turgut
Yazar
[dc.contributor.author]
Koca, Rafet
Yayın Yılı
[dc.date.issued]
2013
Yayıncı
[dc.publisher]
LIPPINCOTT WILLIAMS & WILKINS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background QRS prolongation and the presence of QRS fragmentation in 12-lead ECG are associated with increased mortality and sudden cardiac death in the long term. In this study we aimed to assess QRS duration and fragmentation in patients with Behcet's disease (BD).Methods A total of 50 patients (mean age 42.7 +/- 12.0 years) previously diagnosed with BD were recruited. In addition, a control group consisting of 50 healthy people (mean age 39.4 +/- 12.5 years) was formed. The longest QRS duration was measured in surface 12-lead ECG and QRS complexes were evaluated in terms of fragmentation. Serum C-reactive protein levels were also obtained.Results QRS duration and corrected QT duration were significantly longer in patients with BD compared with controls (102.75 +/- 11.91 vs. 96.99 +/- 10.91 ms, P=0.007; 438.55 +/- 30.80 vs. 420.23 +/- 28.06 ms, P=0.003, respectively). Fragmented QRS (fQRS) pattern was more common in patients with BD than controls [n=27 (54%) vs. n=16 (32%), P=0.026]. Disease duration was longer in patients with BD with fQRS compared with those without (12.67 +/- 8.68 vs. 7.09 +/- 7.06 years, P=0.010). Furthermore, C-reactive protein level was higher in patients with BD with fQRS compared with those without (6.53 +/- 4.11 vs. 4.97 +/- 6.32 mg/dl, P=0.043). Correlation analysis revealed no association between disease duration and QRS duration (r=0.219, P=0.126).Conclusion QRS duration is greater and fQRS complexes are more frequent in patients with BD. These findings may indicate subclinical cardiac involvement in BD. Given the prognostic significance of ECG parameters, it is reasonable to evaluate patients with BD with prolonged and fQRS complexes more in detail such as late potentials in signal averaged ECG in terms of cardiac involvement.
Açıklama
[dc.description]
WOS: 000323225700010
Açıklama
[dc.description]
PubMed: 23612364
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Behcet's disease
Konu Başlıkları
[dc.subject]
fragmented QRS
Konu Başlıkları
[dc.subject]
QRS duration
Konu Başlıkları
[dc.subject]
subclinical cardiac involvement
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0954-6928
İlk Sayfa Sayısı
[dc.identifier.startpage]
398
Son Sayfa Sayısı
[dc.identifier.endpage]
403
Dergi Adı
[dc.relation.journal]
CORONARY ARTERY DISEASE
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/MCA.0b013e328361a978
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2122
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
15 Nisan 2024 09:58
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Tıklayınız
duration patients complexes cardiac compared fragmentation years) without C-reactive protein longer controls disease 12-lead involvement Furthermore common evaluate prolonged averaged detail potentials signal Disease higher association findings indicate frequent subclinical greater Conclusion pattern between reasonable
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