Factors affecting successful treatment outcomes in pulmonary tuberculosis: a single-center experience in Turkey, 2005-2011

Introduction: We aimed to describe the treatment outcomes in patients with bacteriologically confirmed pulmonary tuberculosis (PTB) and identify factors associated with successful treatment outcome. Methodology: The medical charts of patients with smear and/or culture-positive PTB who were treated between 2005 and 2011 at the Kocaeli Tuberculosis Dispensary, Turkey, were reviewed. Patients were categorized as having a successful (cured or with a completed treatment) or poor (treatment default, treatment failure, death) treatment outcome. The association of demographic and clinical factors, including gender, age, education, occupation, insurance, family size, living area, smear and culture positivity, retreatment, comorbidity, drug resistance, and cavity on radiography, with the success of treatment, was evaluated by univariate and multivariate analyses. Results: Of 738 patients (258 females, 480 males) with bacteriologically confirmed PTB, 683 (92.6%) had successful treatment outcomes. Of those with a poor outcome, 29 (3.9%) had treatment default, 18 (2.4%) died, and 8 (1.1%) had treatment failure. Young age, no previous treatment, no comorbidity, no drug resistance, and high education level were factors significantly associated with successful PTB treatment outcome (p < 0.05 for all). Conclusions: Treatment outcome was successful in young and educated PTB patients who had drug resistance, previous treatment history, and no comorbidities. Knowledge of the factors affecting treatment success will lead to the undertaking of specific measures in the management of PTB, which may help to decrease treatment failure.

Yazar Sengul, Aysun
Akturk, Ulku Aka
Aydemir, Yusuf
Kaya, Nurullah
Kocak, Nagihan Durmus
Tasolar, Fatma Turan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2637
Tek Biçim Adres 10.3855/jidc.5925
Konu Başlıkları pulmonary tuberculosis
treatment outcome
drug resistance
Turkey
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
Dergi Cilt Bilgisi 9
Dergi Sayısı 8
Sayfalar 821 - 828
Yayın Yılı 2015
Eser Adı
[dc.title]
Factors affecting successful treatment outcomes in pulmonary tuberculosis: a single-center experience in Turkey, 2005-2011
Yazar
[dc.contributor.author]
Sengul, Aysun
Yazar
[dc.contributor.author]
Akturk, Ulku Aka
Yazar
[dc.contributor.author]
Aydemir, Yusuf
Yazar
[dc.contributor.author]
Kaya, Nurullah
Yazar
[dc.contributor.author]
Kocak, Nagihan Durmus
Yazar
[dc.contributor.author]
Tasolar, Fatma Turan
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
J INFECTION DEVELOPING COUNTRIES
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: We aimed to describe the treatment outcomes in patients with bacteriologically confirmed pulmonary tuberculosis (PTB) and identify factors associated with successful treatment outcome. Methodology: The medical charts of patients with smear and/or culture-positive PTB who were treated between 2005 and 2011 at the Kocaeli Tuberculosis Dispensary, Turkey, were reviewed. Patients were categorized as having a successful (cured or with a completed treatment) or poor (treatment default, treatment failure, death) treatment outcome. The association of demographic and clinical factors, including gender, age, education, occupation, insurance, family size, living area, smear and culture positivity, retreatment, comorbidity, drug resistance, and cavity on radiography, with the success of treatment, was evaluated by univariate and multivariate analyses. Results: Of 738 patients (258 females, 480 males) with bacteriologically confirmed PTB, 683 (92.6%) had successful treatment outcomes. Of those with a poor outcome, 29 (3.9%) had treatment default, 18 (2.4%) died, and 8 (1.1%) had treatment failure. Young age, no previous treatment, no comorbidity, no drug resistance, and high education level were factors significantly associated with successful PTB treatment outcome (p < 0.05 for all). Conclusions: Treatment outcome was successful in young and educated PTB patients who had drug resistance, previous treatment history, and no comorbidities. Knowledge of the factors affecting treatment success will lead to the undertaking of specific measures in the management of PTB, which may help to decrease treatment failure.
Açıklama
[dc.description]
WOS: 000361523100004
Açıklama
[dc.description]
PubMed: 26322873
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
pulmonary tuberculosis
Konu Başlıkları
[dc.subject]
treatment outcome
Konu Başlıkları
[dc.subject]
drug resistance
Konu Başlıkları
[dc.subject]
Turkey
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1972-2680
İlk Sayfa Sayısı
[dc.identifier.startpage]
821
Son Sayfa Sayısı
[dc.identifier.endpage]
828
Dergi Adı
[dc.relation.journal]
JOURNAL OF INFECTION IN DEVELOPING COUNTRIES
Dergi Sayısı
[dc.identifier.issue]
8
Dergi Cilt Bilgisi
[dc.identifier.volume]
9
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3855/jidc.5925
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2637
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142
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1
09.12.2022 tarihinden bu yana
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treatment successful outcome factors patients resistance failure comorbidity previous education success outcomes bacteriologically confirmed associated default females males) Introduction comorbidities decrease management measures specific undertaking affecting Knowledge history educated Treatment Conclusions Results significantly analyses treated
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