Lung clearance of Tc-99m-DTPA in ankylosing spondylitis

The association of ankylosing spondylitis (AS) and lung parenchyma abnormalities has been shown in previous studies by radiological and pulmonary function tests. Technetium-99m diethylene triamine pentaacetic acid Tc-99m-DTPA) dynamic lung scanning is an easy, noninvasive method to assess alveolar-capillary barrier permeability. We aimed to study the abnormalities in pulmonary clearance of Tc-99m-DTPA in patients with AS, and the presence of any correlation between this clearance and the radiological and pulmonary function tests. We studied twenty-one nonsmoker patients with AS who were compared to 21 age and sex matched healthy volunteers. All subjects underwent pulmonary function tests and pulmonary scintigraphy with Tc-99m-DTPA to evaluate pulmonary clearance. Clearance half time (T-1/2) of Tc-99m-DTPA through the lungs was calculated by placing a monoexponential fit on the 30 min activity curves. High resolution CT and pulmonary function tests were performed for each patient. Our results showed the following: Spirometric parameters of forced vital capecity (FVC) and the ratio of forced expiratory value in 1sec/FVC (FEV1%) scores were worse in patients compared to the control group (P<0.005 and P<0.05, respectively). Clearance half time was longer in AS group than in the control group (58.45 +/- 7.59 and 51.62 +/- 4.79 min, respectively; P<0.05). There was a negative correlation between T-1/2 Value and FEV1% (r=-0.876, P < 0.01), of AS patients and the control group. Additionally, there were moderate positive correlation between T-1/2 and FVC (r=0.705, P<0.001), weak positive correlation between T-1/2 and FEF2575 (r = 0.493, P<0.05), and T-1/2 and DLCO (r=0.444, P<0.05). A positive correlation was found between the duration of the disease and T-1/2 (r=0.44, P < 0.05). In conclusion, longer T-1/2 values and lower FVC values in nonsmoker AS patients may suggest not only the pulmonary involvement in AS but also the duration of the disease.

Dergi Adı HELLENIC JOURNAL OF NUCLEAR MEDICINE
Dergi Cilt Bilgisi 12
Dergi Sayısı 1
Sayfalar 17 - 21
Yayın Yılı 2009
Eser Adı
[dc.title]
Lung clearance of Tc-99m-DTPA in ankylosing spondylitis
Yazar
[dc.contributor.author]
Cabuk, Mehmet
Yazar
[dc.contributor.author]
Oezdolap, Senay
Yazar
[dc.contributor.author]
Altin, Remzi
Yazar
[dc.contributor.author]
Kart, Levent
Yazar
[dc.contributor.author]
Peksoy, Irfan
Yazar
[dc.contributor.author]
Sankaya, Selda
Yazar
[dc.contributor.author]
Aksoy, Nilgun Balkan
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
HELLENIC SOC NUCLEAR MEDICINE
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The association of ankylosing spondylitis (AS) and lung parenchyma abnormalities has been shown in previous studies by radiological and pulmonary function tests. Technetium-99m diethylene triamine pentaacetic acid Tc-99m-DTPA) dynamic lung scanning is an easy, noninvasive method to assess alveolar-capillary barrier permeability. We aimed to study the abnormalities in pulmonary clearance of Tc-99m-DTPA in patients with AS, and the presence of any correlation between this clearance and the radiological and pulmonary function tests. We studied twenty-one nonsmoker patients with AS who were compared to 21 age and sex matched healthy volunteers. All subjects underwent pulmonary function tests and pulmonary scintigraphy with Tc-99m-DTPA to evaluate pulmonary clearance. Clearance half time (T-1/2) of Tc-99m-DTPA through the lungs was calculated by placing a monoexponential fit on the 30 min activity curves. High resolution CT and pulmonary function tests were performed for each patient. Our results showed the following: Spirometric parameters of forced vital capecity (FVC) and the ratio of forced expiratory value in 1sec/FVC (FEV1%) scores were worse in patients compared to the control group (P<0.005 and P<0.05, respectively). Clearance half time was longer in AS group than in the control group (58.45 +/- 7.59 and 51.62 +/- 4.79 min, respectively; P<0.05). There was a negative correlation between T-1/2 Value and FEV1% (r=-0.876, P < 0.01), of AS patients and the control group. Additionally, there were moderate positive correlation between T-1/2 and FVC (r=0.705, P<0.001), weak positive correlation between T-1/2 and FEF2575 (r = 0.493, P<0.05), and T-1/2 and DLCO (r=0.444, P<0.05). A positive correlation was found between the duration of the disease and T-1/2 (r=0.44, P < 0.05). In conclusion, longer T-1/2 values and lower FVC values in nonsmoker AS patients may suggest not only the pulmonary involvement in AS but also the duration of the disease.
Açıklama
[dc.description]
WOS: 000265034600005
Açıklama
[dc.description]
PubMed: 19330176
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Alveolo-capillary permeability
Konu Başlıkları
[dc.subject]
Ventilation clearance
Konu Başlıkları
[dc.subject]
Technetium-99m
Konu Başlıkları
[dc.subject]
diethylenetriamine pentaacetic acid
Konu Başlıkları
[dc.subject]
Ankylosing spondylitis
Konu Başlıkları
[dc.subject]
Pulmonary function
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1790-5427
İlk Sayfa Sayısı
[dc.identifier.startpage]
17
Son Sayfa Sayısı
[dc.identifier.endpage]
21
Dergi Adı
[dc.relation.journal]
HELLENIC JOURNAL OF NUCLEAR MEDICINE
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
12
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2903
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 17:08
Google Kontrol
Tıklayınız
pulmonary correlation patients between function positive control clearance Tc-99m-DTPA nonsmoker Clearance longer compared forced values disease radiological abnormalities duration scores suggest expiratory 1sec/FVC (FEV1%) respectively) involvement FEF2575 moderate Additionally conclusion negative respectively curves capecity barrier
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms