Behcet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study

Objective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).

Yazar Uluduz, Derya
Midi, Ipek
Duman, Taskin
Colakoglu, Sena
Tufekci, Ahmet
Bakar, Mustafa
Nazliel, Bijen
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2149
Tek Biçim Adres 10.1093/rheumatology/key153
Konu Başlıkları Behcet's disease
cerebral venous sinus thrombosis
outcome
subgroup analysis
VENOST study
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı RHEUMATOLOGY
Dergi Cilt Bilgisi 58
Dergi Sayısı 4
Sayfalar 600 - 608
Yayın Yılı 2019
Eser Adı
[dc.title]
Behcet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study
Yazar
[dc.contributor.author]
Uluduz, Derya
Yazar
[dc.contributor.author]
Midi, Ipek
Yazar
[dc.contributor.author]
Duman, Taskin
Yazar
[dc.contributor.author]
Colakoglu, Sena
Yazar
[dc.contributor.author]
Tufekci, Ahmet
Yazar
[dc.contributor.author]
Bakar, Mustafa
Yazar
[dc.contributor.author]
Nazliel, Bijen
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
OXFORD UNIV PRESS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).
Açıklama
[dc.description]
WOS: 000465130500010
Açıklama
[dc.description]
PubMed: 29992235
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Behcet's disease
Konu Başlıkları
[dc.subject]
cerebral venous sinus thrombosis
Konu Başlıkları
[dc.subject]
outcome
Konu Başlıkları
[dc.subject]
subgroup analysis
Konu Başlıkları
[dc.subject]
VENOST study
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1462-0324
ISSN
[dc.identifier.issn]
1462-0332
İlk Sayfa Sayısı
[dc.identifier.startpage]
600
Son Sayfa Sayısı
[dc.identifier.endpage]
608
Dergi Adı
[dc.relation.journal]
RHEUMATOLOGY
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
58
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1093/rheumatology/key153
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2149
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
18
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 13:13
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Tıklayınız
patients thrombosis outcome predominant aetiologic factors symptom involvement VENOST sinuses multicentre included followed cerebral venous common defects consistent subacute headache transverse visual superior Conclusions sagittal Objective cranial Rankin (modified beginning consciousness altered presenting functional symptoms
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