Investigation of hypothalamo-pituitary-gonadal axis and glucose intolerance among the firstdegree female relatives of women with polycystic ovary syndrome

Objective: To assess the glucose intolerance and the hypothalamo-pituitary-gonadal (HPG) axis in the first-degree relatives (FDRs) of patients with polycystic ovary syndrome (PCOS). Design: Clinical study of the female FDRs of patients with PCOS. Setting: Outpatients at endocrinology department of a university hospital. Patient(s): Seventy FDRs of PCOS patients and 20 healthy women were evaluated. Intervention(S): Basal hormonal investigations, buserelin test, and 75-g oral glucose tolerance test (OGTT) were performed. Main Outcome Measure(s): Basal hormone levels were measured. Additionally, insulinogenic index, glucose and insulin responses to OGTT, and FSH, LH, E-2, and 17-OHP responses to buserelin test were obtained. Result(S): Four (5.7%) of the FDRs showed impaired glucose tolerance, and the FDRs had significantly higher fasting plasma glucose (P <.05) and basal insulin (P <.01) than control subjects. Peak and area-under-the-curve (AUC) insulin (P <.001) and AUC glucose (P <.05) responses to OGTT were also significantly higher in the FDRs than in control subjects. The FDRs showed higher insulinogenic index than the control subjects (P < 001). The FDRs had significantly (P < 05) higher LH and DHEAS levels and lower (P <.005) 17-OHP levels than the control subjects. Peak (P < 05) and AUC (P <.01) LH responses to buserelin testing were lower in the FDRs than in the control subjects while peak (P <.05) and AUC (P <.01) E, responses to buserelin were higher in the FDRs than in the control subjects. Conclusion(s): These data support the hypothesis that FDRs of PCOS patients may have insulin resistance and the HPG axis is more susceptible than in control subjects. The FDRs also have an increased prevalence of hyperandrogenism and high DHEAS levels compared with the background population.

Yazar Unluhizarci, Kursad
Ozocak, Mehtap
Tanriverdi, Fatih
Atmaca, Hulusi
Kelestimur, Fahrettin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2820
Tek Biçim Adres 10.1016/j.fertnstert.2006.11.075
Konu Başlıkları glucose intolerance
first-degree relative
PCOS
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı FERTILITY AND STERILITY
Dergi Cilt Bilgisi 87
Dergi Sayısı 6
Sayfalar 1377 - 1382
Yayın Yılı 2007
Eser Adı
[dc.title]
Investigation of hypothalamo-pituitary-gonadal axis and glucose intolerance among the firstdegree female relatives of women with polycystic ovary syndrome
Yazar
[dc.contributor.author]
Unluhizarci, Kursad
Yazar
[dc.contributor.author]
Ozocak, Mehtap
Yazar
[dc.contributor.author]
Tanriverdi, Fatih
Yazar
[dc.contributor.author]
Atmaca, Hulusi
Yazar
[dc.contributor.author]
Kelestimur, Fahrettin
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: To assess the glucose intolerance and the hypothalamo-pituitary-gonadal (HPG) axis in the first-degree relatives (FDRs) of patients with polycystic ovary syndrome (PCOS). Design: Clinical study of the female FDRs of patients with PCOS. Setting: Outpatients at endocrinology department of a university hospital. Patient(s): Seventy FDRs of PCOS patients and 20 healthy women were evaluated. Intervention(S): Basal hormonal investigations, buserelin test, and 75-g oral glucose tolerance test (OGTT) were performed. Main Outcome Measure(s): Basal hormone levels were measured. Additionally, insulinogenic index, glucose and insulin responses to OGTT, and FSH, LH, E-2, and 17-OHP responses to buserelin test were obtained. Result(S): Four (5.7%) of the FDRs showed impaired glucose tolerance, and the FDRs had significantly higher fasting plasma glucose (P <.05) and basal insulin (P <.01) than control subjects. Peak and area-under-the-curve (AUC) insulin (P <.001) and AUC glucose (P <.05) responses to OGTT were also significantly higher in the FDRs than in control subjects. The FDRs showed higher insulinogenic index than the control subjects (P < 001). The FDRs had significantly (P < 05) higher LH and DHEAS levels and lower (P <.005) 17-OHP levels than the control subjects. Peak (P < 05) and AUC (P <.01) LH responses to buserelin testing were lower in the FDRs than in the control subjects while peak (P <.05) and AUC (P <.01) E, responses to buserelin were higher in the FDRs than in the control subjects. Conclusion(s): These data support the hypothesis that FDRs of PCOS patients may have insulin resistance and the HPG axis is more susceptible than in control subjects. The FDRs also have an increased prevalence of hyperandrogenism and high DHEAS levels compared with the background population.
Açıklama
[dc.description]
7th European Congress of Endocrinology -- SEP 03-07, 2005 -- Gothenburg, SWEDEN
Açıklama
[dc.description]
WOS: 000247150100021
Açıklama
[dc.description]
PubMed: 17336975
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
glucose intolerance
Konu Başlıkları
[dc.subject]
first-degree relative
Konu Başlıkları
[dc.subject]
PCOS
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0015-0282
ISSN
[dc.identifier.issn]
1556-5653
İlk Sayfa Sayısı
[dc.identifier.startpage]
1377
Son Sayfa Sayısı
[dc.identifier.endpage]
1382
Dergi Adı
[dc.relation.journal]
FERTILITY AND STERILITY
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
87
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.fertnstert.2006.11.075
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2820
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Ocak 2024 20:12
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Tıklayınız
subjects control glucose higher responses levels insulin buserelin patients significantly insulinogenic showed tolerance 17-OHP plasma fasting area-under-the-curve population background compared hyperandrogenism prevalence increased susceptible testing resistance hypothesis support Conclusion(s) impaired Objective (PCOS) department endocrinology Outpatients
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