The impact of the extent and severity of coronary artery disease on fractional flow reserve measurements

OBJECTIVE: Coronary angiography has a limitation to determine the severity of intermediate stenosis (30-70%)(1,2). Fractional flow reserve (FFR) is a method for the assessment of the intermediate stenosis severity(3). The effect of coronary artery disease (CAD) severity on the FFR results is not clear. In this study, we aimed to expose the effect of CAD severity calculated with Syntax and Gensini scores on FFR results. PATIENTS AND METHODS: We scanned patients data (n= 378) who had undergone fractional flow reserve measurements in our center. Patients with acute coronary syndrome in the last month, moderate or severe valvular diseases, acute heart failure, serious bradycardia, atrial fibrillation/flutter, severe left ventricular hypertrophy or patient with deficient data were excluded. 351 patients were included in the study. Syntax and Gensini scores were calculated and compared with FFR results. Hemodynamically significant result for FFR, ratio <0.80 was accepted. RESULTS: The negative correlation between high Gensini, high Syntax scores and FFR results was statistically significant. Especially patients with Syntax scores >22 had notable more crucial lesions in FFR measurements (p<0.001). Cardiovascular disease risk factors such as age, gender, hypertension, diabetes mellitus and dyslipidemia did not correlate with the FFR results. Patients with intermediate stenosis (30-70%) and high Gensini and high Syntax scores were found to have more hemodynamically significant on FFR measurements (FFR < 0.80). CONCLUSIONS: Intermediate lesions with high Syntax score should be evaluated by hemodynamic procedures and treated more carefully with optimal medical treatment or revascularization. Revascularization method of CAD with high Syntax score should be decided with hemodynamic procedures as FFR measurements.

Yazar Sahan, E.
Sahan, S.
Karamanlioglu, M.
Gul, M.
Kalayci, S.
Boyaci, A.
Dereagzi, F.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3605
Konu Başlıkları Fractional flow reserve
Syntax score
Gensini score
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Dergi Cilt Bilgisi 20
Dergi Sayısı 16
Sayfalar 3434 - 3439
Yayın Yılı 2016
Eser Adı
[dc.title]
The impact of the extent and severity of coronary artery disease on fractional flow reserve measurements
Yazar
[dc.contributor.author]
Sahan, E.
Yazar
[dc.contributor.author]
Sahan, S.
Yazar
[dc.contributor.author]
Karamanlioglu, M.
Yazar
[dc.contributor.author]
Gul, M.
Yazar
[dc.contributor.author]
Kalayci, S.
Yazar
[dc.contributor.author]
Boyaci, A.
Yazar
[dc.contributor.author]
Dereagzi, F.
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
VERDUCI PUBLISHER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
OBJECTIVE: Coronary angiography has a limitation to determine the severity of intermediate stenosis (30-70%)(1,2). Fractional flow reserve (FFR) is a method for the assessment of the intermediate stenosis severity(3). The effect of coronary artery disease (CAD) severity on the FFR results is not clear. In this study, we aimed to expose the effect of CAD severity calculated with Syntax and Gensini scores on FFR results. PATIENTS AND METHODS: We scanned patients data (n= 378) who had undergone fractional flow reserve measurements in our center. Patients with acute coronary syndrome in the last month, moderate or severe valvular diseases, acute heart failure, serious bradycardia, atrial fibrillation/flutter, severe left ventricular hypertrophy or patient with deficient data were excluded. 351 patients were included in the study. Syntax and Gensini scores were calculated and compared with FFR results. Hemodynamically significant result for FFR, ratio <0.80 was accepted. RESULTS: The negative correlation between high Gensini, high Syntax scores and FFR results was statistically significant. Especially patients with Syntax scores >22 had notable more crucial lesions in FFR measurements (p<0.001). Cardiovascular disease risk factors such as age, gender, hypertension, diabetes mellitus and dyslipidemia did not correlate with the FFR results. Patients with intermediate stenosis (30-70%) and high Gensini and high Syntax scores were found to have more hemodynamically significant on FFR measurements (FFR < 0.80). CONCLUSIONS: Intermediate lesions with high Syntax score should be evaluated by hemodynamic procedures and treated more carefully with optimal medical treatment or revascularization. Revascularization method of CAD with high Syntax score should be decided with hemodynamic procedures as FFR measurements.
Açıklama
[dc.description]
WOS: 000384168600016
Açıklama
[dc.description]
PubMed: 27608903
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Fractional flow reserve
Konu Başlıkları
[dc.subject]
Syntax score
Konu Başlıkları
[dc.subject]
Gensini score
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1128-3602
İlk Sayfa Sayısı
[dc.identifier.startpage]
3434
Son Sayfa Sayısı
[dc.identifier.endpage]
3439
Dergi Adı
[dc.relation.journal]
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
Dergi Sayısı
[dc.identifier.issue]
16
Dergi Cilt Bilgisi
[dc.identifier.volume]
20
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3605
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
6
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Eylül 2023 16:45
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Syntax scores results measurements Gensini severity intermediate stenosis significant patients calculated lesions Patients severe should coronary hemodynamic method procedures effect disease reserve Cardiovascular medical treatment notable crucial optimal Especially statistically revascularization Revascularization between correlation negative
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