Platelet Indices in Patients with Coal Workers' Pneumoconiosis

Coal workers' pneumoconiosis (CWP) is caused by an accumulation of coal particles in the lung parenchyma. Reactive oxygen species (ROS) play an important role in the pathogenesis of CWP. It is well documented that ROS stimulate platelet activation, adhesion, and aggregation. The aim of the present study was to investigate the relationship between platelet indices and CWP. The demographic features, occupational and medical history, exposure time, and complete blood count of retired coal miners were retrospectively analysed. The control group comprised healthy subjects who had not worked underground. Chest radiographs were evaluated according to the CWP classification of the International Labour Office. The study population was divided into following groups: 50 controls, 97 without CWP, 142 simple pneumoconiosis (SP), 157 progressive massive fibrosis (PMF). The platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) were significantly higher in patients with CWP compared to those in patients without CWP and controls. The platelet count, MPV, and PCT were higher in patients with PMF compared to those in the SP group (p < 0.05). The results of multiple logistic regression analyses indicated that the platelet count, MPV, and PCT were independently associated with the development of CWP. Platelet indices may be considered as disease markers for pneumoconiosis in coal miners and as a useful indicator of the progression of pneumoconiosis.

Yazar Uygur, Firat
Ornek, Tacettin
Tanriverdi, Hakan
Altuntas, Murat
Altinsoy, Bulent
Erboy, Fatma
Tor, Meltem
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3102
Tek Biçim Adres 10.1007/s00408-016-9883-2
Konu Başlıkları Pneumoconiosis
Coal mine
Platelet indices
Reactive oxygen species
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı LUNG
Dergi Cilt Bilgisi 194
Dergi Sayısı 4
Sayfalar 675 - 679
Yayın Yılı 2016
Eser Adı
[dc.title]
Platelet Indices in Patients with Coal Workers' Pneumoconiosis
Yazar
[dc.contributor.author]
Uygur, Firat
Yazar
[dc.contributor.author]
Ornek, Tacettin
Yazar
[dc.contributor.author]
Tanriverdi, Hakan
Yazar
[dc.contributor.author]
Altuntas, Murat
Yazar
[dc.contributor.author]
Altinsoy, Bulent
Yazar
[dc.contributor.author]
Erboy, Fatma
Yazar
[dc.contributor.author]
Tor, Meltem
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
SPRINGER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Coal workers' pneumoconiosis (CWP) is caused by an accumulation of coal particles in the lung parenchyma. Reactive oxygen species (ROS) play an important role in the pathogenesis of CWP. It is well documented that ROS stimulate platelet activation, adhesion, and aggregation. The aim of the present study was to investigate the relationship between platelet indices and CWP. The demographic features, occupational and medical history, exposure time, and complete blood count of retired coal miners were retrospectively analysed. The control group comprised healthy subjects who had not worked underground. Chest radiographs were evaluated according to the CWP classification of the International Labour Office. The study population was divided into following groups: 50 controls, 97 without CWP, 142 simple pneumoconiosis (SP), 157 progressive massive fibrosis (PMF). The platelet count, mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) were significantly higher in patients with CWP compared to those in patients without CWP and controls. The platelet count, MPV, and PCT were higher in patients with PMF compared to those in the SP group (p < 0.05). The results of multiple logistic regression analyses indicated that the platelet count, MPV, and PCT were independently associated with the development of CWP. Platelet indices may be considered as disease markers for pneumoconiosis in coal miners and as a useful indicator of the progression of pneumoconiosis.
Açıklama
[dc.description]
WOS: 000380278500024
Açıklama
[dc.description]
PubMed: 27107875
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Pneumoconiosis
Konu Başlıkları
[dc.subject]
Coal mine
Konu Başlıkları
[dc.subject]
Platelet indices
Konu Başlıkları
[dc.subject]
Reactive oxygen species
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0341-2040
ISSN
[dc.identifier.issn]
1432-1750
İlk Sayfa Sayısı
[dc.identifier.startpage]
675
Son Sayfa Sayısı
[dc.identifier.endpage]
679
Dergi Adı
[dc.relation.journal]
LUNG
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
194
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s00408-016-9883-2
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3102
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
295
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
16 Temmuz 2024 13:53
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Tıklayınız
platelet pneumoconiosis patients without compared indices higher controls miners fibrosis simple progressive massive significantly groups distribution plateletcrit volume development progression indicator useful markers disease considered Platelet associated independently indicated analyses regression logistic multiple results following
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