Gastroprotective effects of CoQ(10) on ethanol-induced acute gastric lesions

Introduction: Alcohol consumption is frequently associated with gastric mucosa! lesions. The purpose of this study was to determine the effect of Coenzyme-Q(10) (CoQ(10)) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ(10), at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrificed and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. Results and discussion: Rats pretreated either with famotidine or CoQ(10) had significantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were significantly lower in famotidine 20 mg/kg and CoQ(10), pretreatment for 7 days group (p < 0.00625). Conclusion: CoQ(10) affords gastroprotection against ethanol-induced gastric mucosal lesions in rats especially after repetitive administrations (Tab. 3, Fig. 2, Ref. 35). Text in PDF www.elis.sk.

Dergi Adı BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Dergi Cilt Bilgisi 116
Dergi Sayısı 1
Sayfalar 51 - 56
Yayın Yılı 2015
Eser Adı
[dc.title]
Gastroprotective effects of CoQ(10) on ethanol-induced acute gastric lesions
Yazar
[dc.contributor.author]
Karakaya, K.
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Hanci, V
Yazar
[dc.contributor.author]
Can, M.
Yazar
[dc.contributor.author]
Comert, M.
Yazar
[dc.contributor.author]
Ucan, H. B.
Yazar
[dc.contributor.author]
Cakmak, G. K.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
COMENIUS UNIV
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: Alcohol consumption is frequently associated with gastric mucosa! lesions. The purpose of this study was to determine the effect of Coenzyme-Q(10) (CoQ(10)) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ(10), at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrificed and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. Results and discussion: Rats pretreated either with famotidine or CoQ(10) had significantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were significantly lower in famotidine 20 mg/kg and CoQ(10), pretreatment for 7 days group (p < 0.00625). Conclusion: CoQ(10) affords gastroprotection against ethanol-induced gastric mucosal lesions in rats especially after repetitive administrations (Tab. 3, Fig. 2, Ref. 35). Text in PDF www.elis.sk.
Açıklama
[dc.description]
WOS: 000349275900010
Açıklama
[dc.description]
PubMed: 25666963
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
gastric ulceration
Konu Başlıkları
[dc.subject]
ethanol
Konu Başlıkları
[dc.subject]
Coenzyme-Q(10)
Konu Başlıkları
[dc.subject]
rats
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0006-9248
ISSN
[dc.identifier.issn]
1336-0345
İlk Sayfa Sayısı
[dc.identifier.startpage]
51
Son Sayfa Sayısı
[dc.identifier.endpage]
56
Dergi Adı
[dc.relation.journal]
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
116
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4149/BLL_2015_010
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2674
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 05:58
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Tıklayınız
gastric CoQ(10) pretreatment mucosal ethanol 00625) albino groups significantly famotidine lesions damage ethanol-induced pretreated ketamin anaesthesia Gastric protection evaluated discussion measuring concentrations histopathological studies Results Introduction analysis either especially administrations repetitive against gastroprotection affords Conclusion
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