Liver Function Assessment by Magnetic Resonance Imaging

Liver function assessment by hepatocyte-specific contrast-enhanced magnetic resonance imaging is becoming a new biomarker. Liver function can be assessed by T1 mapping (reduction rate) and signal intensity measurement (relative enhancement ratio) before and after GD-EOB-DTPA (gadoxetic acid) administration, as alternative to Tc-99m galactosyl serum albumin scintigraphy, 99m Tc-labeled mebrofenin scintigraphy, and indocyanine green clearance test. Magnetic resonance imaging assessment of liver function can enable diagnosis of cirrhosis, nonalcoholic fatty liver disease associated fibrosis and steatohepatitis, primary sclerosing cholangitis, toxic hepatitis, and chemotherapy and radiotherapy-related changes, which may be only visible on hepatobiliary phase images. Simple visual assessment of signal intensity at hepatobiliary phase images is important for the diagnosis of different patterns of liver dysfunction including diffuse, lobar, segmental, and subsegmental forms. Furthermore, preoperative assessment of liver function is feasible before oncologic hepatic surgery, which may be important to prevent posthepatectomy liver failure and to estimate future remnant volume. Functional magnetic resonance cholangiography obtained by T1-weighted images at hepatobiliary phase can allow diagnosis of acalculous cholecystitis, biliary leakage, bile reflux to the stomach, sphincter of oddi dysfunction, and lesions with communication to biliary tree. Functional information can be easily obtained when Gd-EOB-DTPA is used for liver magnetic resonance imaging. (C) 2016 Elsevier Inc. All rights reserved.

Yazar Unal, Emre
Akata, Deniz
Karcaaltincaba, Musturay
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2888
Tek Biçim Adres 10.1053/j.sult.2016.08.006
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı SEMINARS IN ULTRASOUND CT AND MRI
Dergi Cilt Bilgisi 37
Dergi Sayısı 6
Sayfalar 549 - 560
Yayın Yılı 2016
Eser Adı
[dc.title]
Liver Function Assessment by Magnetic Resonance Imaging
Yazar
[dc.contributor.author]
Unal, Emre
Yazar
[dc.contributor.author]
Akata, Deniz
Yazar
[dc.contributor.author]
Karcaaltincaba, Musturay
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
W B SAUNDERS CO-ELSEVIER INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Liver function assessment by hepatocyte-specific contrast-enhanced magnetic resonance imaging is becoming a new biomarker. Liver function can be assessed by T1 mapping (reduction rate) and signal intensity measurement (relative enhancement ratio) before and after GD-EOB-DTPA (gadoxetic acid) administration, as alternative to Tc-99m galactosyl serum albumin scintigraphy, 99m Tc-labeled mebrofenin scintigraphy, and indocyanine green clearance test. Magnetic resonance imaging assessment of liver function can enable diagnosis of cirrhosis, nonalcoholic fatty liver disease associated fibrosis and steatohepatitis, primary sclerosing cholangitis, toxic hepatitis, and chemotherapy and radiotherapy-related changes, which may be only visible on hepatobiliary phase images. Simple visual assessment of signal intensity at hepatobiliary phase images is important for the diagnosis of different patterns of liver dysfunction including diffuse, lobar, segmental, and subsegmental forms. Furthermore, preoperative assessment of liver function is feasible before oncologic hepatic surgery, which may be important to prevent posthepatectomy liver failure and to estimate future remnant volume. Functional magnetic resonance cholangiography obtained by T1-weighted images at hepatobiliary phase can allow diagnosis of acalculous cholecystitis, biliary leakage, bile reflux to the stomach, sphincter of oddi dysfunction, and lesions with communication to biliary tree. Functional information can be easily obtained when Gd-EOB-DTPA is used for liver magnetic resonance imaging. (C) 2016 Elsevier Inc. All rights reserved.
Açıklama
[dc.description]
WOS: 000390635200006
Açıklama
[dc.description]
PubMed: 27986173
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0887-2171
ISSN
[dc.identifier.issn]
1558-5034
İlk Sayfa Sayısı
[dc.identifier.startpage]
549
Son Sayfa Sayısı
[dc.identifier.endpage]
560
Dergi Adı
[dc.relation.journal]
SEMINARS IN ULTRASOUND CT AND MRI
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
37
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1053/j.sult.2016.08.006
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2888
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 22:04
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assessment resonance function magnetic imaging images hepatobiliary diagnosis important Functional scintigraphy obtained dysfunction biliary signal before intensity lesions Gd-EOB-DTPA feasible preoperative Furthermore subsegmental segmental diffuse including hepatic patterns different Elsevier rights reserved oncologic posthepatectomy surgery
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