MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy

Objectives: To evaluate the magnetic resonance imaging (MRI)-derived parameters in differentiation of patients with progressive supranuclear palsy (PSP) from patients with Parkinson's disease (PD), multiple system atrophy (MSA), and control subjects was aimed. Methods: Thirty-three patients [mean age, 65.21 +/- 4.75 years; PSP (n = 9), MSA (n = 8), PD (n = 6), and control subjects (n = 10)] who have undergone cranial MRI were included in this retrospective study. MRI-derived parameters including areas of midbrain and pons, midbrain area-to-pons area (M/P) ratio, widths of middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP), MCP/SCP ratio, magnetic resonance parkinsonism index (MRPI), cerebral interpeduncular angle, and length of midbrain tegmentum were compared in patients with PSP, PD, MSA, and control subjects through the analysis of variance and Kruskal-Wallis tests with Bonferroni correction and Mann-Whitney U test. Results: The length of midbrain tegmentum, midbrain area, SCP, and M/P ratio were found to be lower, while cerebral interpeduncular angle and MRPI were higher in patients with PSP. Pons area, MCP width, and MCP/SCP ratio were found to be lower in patients with MSA. For PSP, cerebral interpeduncular angle has a sensitivity of 100% and specifity of 90%, and MRPI had a sensitivity of 88.9% and specifity of 100% for PSP. Discussion: Several MRI-derived parameters can be used in differentiation of patients with PSP from patients with PD, MSA and control subjects. The cerebral interpeduncular angle and MRPI, which demonstrated higher values in patients with PSP, were more significant for PSP than the other parameters.

Yazar Eraslan, Cenk
Acarer, Ahmet
Guneyli, Serkan
Akyuz, Esra
Aydin, Elcin
Colakoglu, Zafer
Kitis, Omer
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2964
Tek Biçim Adres 10.1080/01616412.2018.1541115
Konu Başlıkları MRI
magnetic resonance parkinsonism index
multiple system atrophy
Parkinson's disease
progressive supranuclear palsy
interpeduncular angle
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı NEUROLOGICAL RESEARCH
Dergi Cilt Bilgisi 41
Dergi Sayısı 2
Sayfalar 110 - 117
Yayın Yılı 2019
Eser Adı
[dc.title]
MRI evaluation of progressive supranuclear palsy: differentiation from Parkinson's disease and multiple system atrophy
Yazar
[dc.contributor.author]
Eraslan, Cenk
Yazar
[dc.contributor.author]
Acarer, Ahmet
Yazar
[dc.contributor.author]
Guneyli, Serkan
Yazar
[dc.contributor.author]
Akyuz, Esra
Yazar
[dc.contributor.author]
Aydin, Elcin
Yazar
[dc.contributor.author]
Colakoglu, Zafer
Yazar
[dc.contributor.author]
Kitis, Omer
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: To evaluate the magnetic resonance imaging (MRI)-derived parameters in differentiation of patients with progressive supranuclear palsy (PSP) from patients with Parkinson's disease (PD), multiple system atrophy (MSA), and control subjects was aimed. Methods: Thirty-three patients [mean age, 65.21 +/- 4.75 years; PSP (n = 9), MSA (n = 8), PD (n = 6), and control subjects (n = 10)] who have undergone cranial MRI were included in this retrospective study. MRI-derived parameters including areas of midbrain and pons, midbrain area-to-pons area (M/P) ratio, widths of middle cerebellar peduncle (MCP) and superior cerebellar peduncle (SCP), MCP/SCP ratio, magnetic resonance parkinsonism index (MRPI), cerebral interpeduncular angle, and length of midbrain tegmentum were compared in patients with PSP, PD, MSA, and control subjects through the analysis of variance and Kruskal-Wallis tests with Bonferroni correction and Mann-Whitney U test. Results: The length of midbrain tegmentum, midbrain area, SCP, and M/P ratio were found to be lower, while cerebral interpeduncular angle and MRPI were higher in patients with PSP. Pons area, MCP width, and MCP/SCP ratio were found to be lower in patients with MSA. For PSP, cerebral interpeduncular angle has a sensitivity of 100% and specifity of 90%, and MRPI had a sensitivity of 88.9% and specifity of 100% for PSP. Discussion: Several MRI-derived parameters can be used in differentiation of patients with PSP from patients with PD, MSA and control subjects. The cerebral interpeduncular angle and MRPI, which demonstrated higher values in patients with PSP, were more significant for PSP than the other parameters.
Açıklama
[dc.description]
WOS: 000459561000002
Açıklama
[dc.description]
PubMed: 30373485
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
MRI
Konu Başlıkları
[dc.subject]
magnetic resonance parkinsonism index
Konu Başlıkları
[dc.subject]
multiple system atrophy
Konu Başlıkları
[dc.subject]
Parkinson's disease
Konu Başlıkları
[dc.subject]
progressive supranuclear palsy
Konu Başlıkları
[dc.subject]
interpeduncular angle
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0161-6412
ISSN
[dc.identifier.issn]
1743-1328
İlk Sayfa Sayısı
[dc.identifier.startpage]
110
Son Sayfa Sayısı
[dc.identifier.endpage]
117
Dergi Adı
[dc.relation.journal]
NEUROLOGICAL RESEARCH
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
41
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/01616412.2018.1541115
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2964
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
34
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 21:12
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patients midbrain subjects control cerebral interpeduncular parameters peduncle tegmentum length MRI-derived MCP/SCP cerebellar higher differentiation magnetic sensitivity resonance specifity Kruskal-Wallis variance demonstrated values compared analysis through Bonferroni significant correction Discussion Mann-Whitney Several Results Objectives area-to-pons
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