Is lymph node ratio prognostic factor for survival in elderly patients with node positive breast cancer? The Anatolian Society of Medical Oncology

Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of axillary tumor burden to the number of excised nodes. While, about the prognostic value of LNR on the the survival of elderly patients is limited. The aim of this retrospective multicenter study is to evaluate the prognostic value of lymph node ratio in elderly patients with node positive breast cancer. METHODS: Onehundredeightyfour patient with operable breast cancer, recruited from 17 institutions, were enrolled into the retrospectively study. Eleven potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. RESULT: Among the eleven variables of univariate analysis, four variables were identified to have prognostic significance for Overall survival (OS): pathologic tumor size (T), No. of positive nodes (N), LNR and estrogen receptor-positive (ER). Among the eleven variables of univariate analysis, two variables were identified to have prognostic significance for Disease-free survival (DFS): N and LNR. Multivariate analysis by Cox proportional hazard model showed that 7; LNR and ER were considered independent prognostic factors for OS. Furthermore, LNR was considered independent prognostic factors for DFS. CONCLUSION: In conclusion, the LNR was associated with the prognostic importance for DFS and OS in elderly patients who were administered adjuvant treatments.

Yazar Inal, Ali
Akman, Tulay
Yaman, Sebnem
Ozturk, Selcuk Cemil
Geredeli, Caglayan
Bilici, Mehmet
Inanc, Mevlude
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2848
Konu Başlıkları Breast cancer
Elderly patients
Lymph Node Ratio
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ANNALI ITALIANI DI CHIRURGIA
Dergi Cilt Bilgisi 84
Dergi Sayısı 2
Sayfalar 143 - 148
Yayın Yılı 2013
Eser Adı
[dc.title]
Is lymph node ratio prognostic factor for survival in elderly patients with node positive breast cancer? The Anatolian Society of Medical Oncology
Yazar
[dc.contributor.author]
Inal, Ali
Yazar
[dc.contributor.author]
Akman, Tulay
Yazar
[dc.contributor.author]
Yaman, Sebnem
Yazar
[dc.contributor.author]
Ozturk, Selcuk Cemil
Yazar
[dc.contributor.author]
Geredeli, Caglayan
Yazar
[dc.contributor.author]
Bilici, Mehmet
Yazar
[dc.contributor.author]
Inanc, Mevlude
Yayın Yılı
[dc.date.issued]
2013
Yayıncı
[dc.publisher]
EDIZIONI LUIGI POZZI
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Several studies have now demonstrated that the lymph node ratio (LNR), as a superior indicator of axillary tumor burden to the number of excised nodes. While, about the prognostic value of LNR on the the survival of elderly patients is limited. The aim of this retrospective multicenter study is to evaluate the prognostic value of lymph node ratio in elderly patients with node positive breast cancer. METHODS: Onehundredeightyfour patient with operable breast cancer, recruited from 17 institutions, were enrolled into the retrospectively study. Eleven potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. RESULT: Among the eleven variables of univariate analysis, four variables were identified to have prognostic significance for Overall survival (OS): pathologic tumor size (T), No. of positive nodes (N), LNR and estrogen receptor-positive (ER). Among the eleven variables of univariate analysis, two variables were identified to have prognostic significance for Disease-free survival (DFS): N and LNR. Multivariate analysis by Cox proportional hazard model showed that 7; LNR and ER were considered independent prognostic factors for OS. Furthermore, LNR was considered independent prognostic factors for DFS. CONCLUSION: In conclusion, the LNR was associated with the prognostic importance for DFS and OS in elderly patients who were administered adjuvant treatments.
Açıklama
[dc.description]
WOS: 000320292300004
Açıklama
[dc.description]
PubMed: 23698146
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Breast cancer
Konu Başlıkları
[dc.subject]
Elderly patients
Konu Başlıkları
[dc.subject]
Lymph Node Ratio
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0003-469X
ISSN
[dc.identifier.issn]
2239-253X
İlk Sayfa Sayısı
[dc.identifier.startpage]
143
Son Sayfa Sayısı
[dc.identifier.endpage]
148
Dergi Adı
[dc.relation.journal]
ANNALI ITALIANI DI CHIRURGIA
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
84
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2848
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 05:12
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prognostic variables survival analysis elderly patients factors univariate positive breast cancer considered associated identified significance eleven independent pathologic estrogen receptor-positive Overall Several Furthermore treatments adjuvant administered importance conclusion CONCLUSION Disease-free showed hazard proportional Multivariate Eleven
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