Objective: In the first assessment of trauma patients with major vascular injuries, we need effective and rapid-acting homeostatic materials. In this study we compare the efficiencies of Ankaferd Blood Stopper (R) and a chitosan linear polymer (Celox (R)) in an experimental rat model with femoral artery bleeding. Materials and Methods: Thirty male Wistar albino rats weighing 200250 g were divided into 3 groups: control, Ankaferd, and chitosan. The femoral artery and vein were visualized and bleeding was started by an incision. The bleeding time was recorded and categorized as 'bleeding stopped at the second minute', 'bleeding stopped at the fourth minute', and 'unsuccessful' if bleeding continued after the fourth minute. Results: In the control group, 60% of the bleeding did not stop. In the first 4 min in the Ankaferd group, the bleeding stopped in all rats; only in 1 of the rats in the chitosan group did the bleeding not stop. In stopping the bleeding in the first 4 min, Ankaferd was similar to chitosan but better than the control group; the chitosan group was similar to the control, but the p-value was close to significance. Conclusion: For major arterial bleeding, the main treatment is surgical bleeding control, but outside of the hospital we can use buffers containing Ankaferd and chitosan on the bleeding region. The results of this study should be supported with larger studies. Furthermore, in our study, healthy rats were used. New studies are needed to evaluate the results of hypovolemic and hypotensive cases with major artery bleeding.
Eser Adı (dc.title) | Comparison of the efficiencies of buffers containing ankaferd and chitosan on hemostasis in an experimental rat model with femoral artery bleeding |
Yazar (dc.contributor.author) | Abacıoğlu, Serkan |
Yazar (dc.contributor.author) | Aydın, Kemal |
Yazar (dc.contributor.author) | Büyükcam, Fatih |
Yazar (dc.contributor.author) | Kaya, Ural |
Yazar (dc.contributor.author) | Işık, Bahattin |
Yazar (dc.contributor.author) | Karakılıç, Muhammed Evvah |
Yayın Yılı (dc.date.issued) | 2016 |
Yayıncı (dc.publisher) | GALENOS YAYINCILIK |
Yayın Türü (dc.type) | article |
Özet (dc.description.abstract) | Objective: In the first assessment of trauma patients with major vascular injuries, we need effective and rapid-acting homeostatic materials. In this study we compare the efficiencies of Ankaferd Blood Stopper (R) and a chitosan linear polymer (Celox (R)) in an experimental rat model with femoral artery bleeding. Materials and Methods: Thirty male Wistar albino rats weighing 200250 g were divided into 3 groups: control, Ankaferd, and chitosan. The femoral artery and vein were visualized and bleeding was started by an incision. The bleeding time was recorded and categorized as 'bleeding stopped at the second minute', 'bleeding stopped at the fourth minute', and 'unsuccessful' if bleeding continued after the fourth minute. Results: In the control group, 60% of the bleeding did not stop. In the first 4 min in the Ankaferd group, the bleeding stopped in all rats; only in 1 of the rats in the chitosan group did the bleeding not stop. In stopping the bleeding in the first 4 min, Ankaferd was similar to chitosan but better than the control group; the chitosan group was similar to the control, but the p-value was close to significance. Conclusion: For major arterial bleeding, the main treatment is surgical bleeding control, but outside of the hospital we can use buffers containing Ankaferd and chitosan on the bleeding region. The results of this study should be supported with larger studies. Furthermore, in our study, healthy rats were used. New studies are needed to evaluate the results of hypovolemic and hypotensive cases with major artery bleeding. |
Açıklama (dc.description) | WOS: 000378165300008 |
Açıklama (dc.description) | PubMed: 25913214 |
Kayıt Giriş Tarihi (dc.date.accessioned) | 2019-12-23 |
(dc.date.available) | 2019-12-23 |
Yayın Dili (dc.language.iso) | eng |
Konu Başlıkları (dc.subject) | Bleeding |
Konu Başlıkları (dc.subject) | Ankaferd |
Konu Başlıkları (dc.subject) | Chitosan |
Konu Başlıkları (dc.subject) | Hemostasis |
Künye (dc.identifier.citation) | Abacioğlu, S., Aydin, K., Büyükcam, F., Kaya, U., Işik, B. ve Karakiliç, M. E. (2016). Comparison of the efficiencies of buffers containing ankaferd and chitosan on hemostasis in an experimental rat model with femoral artery bleeding. Turkish Journal of Hematology, 33(1), 48-52. |
Haklar (dc.rights) | info:eu-repo/semantics/openAccess |
ISSN (dc.identifier.issn) | 1300-7777 |
ISSN (dc.identifier.issn) | 1308-5263 |
İlk Sayfa Sayısı (dc.identifier.startpage) | 48 |
Son Sayfa Sayısı (dc.identifier.endpage) | 52 |
Dergi Adı (dc.relation.journal) | TURKISH JOURNAL OF HEMATOLOGY |
Dergi Sayısı (dc.identifier.issue) | 1 |
Dergi Cilt Bilgisi (dc.identifier.volume) | 33 |
Tek Biçim Adres (dc.identifier.uri) | https://dx.doi.org/10.4274/tjh.2014.0029 |
Tek Biçim Adres (dc.identifier.uri) | https://hdl.handle.net/20.500.12628/2287 |
Tek Biçim Adres (dc.identifier.uri) | http://www.trdizin.gov.tr/publication/paper/detail/TVRrNU1UZzBOQT09 |