Comparison of the efficiencies of buffers containing ankaferd and chitosan on hemostasis in an experimental rat model with femoral artery bleeding

Objective: In the first assessment of trauma patients with major vascular injuries, we need effective and rapid-acting homeostatic materials. In this study we compare the efficiencies of Ankaferd Blood Stopper (R) and a chitosan linear polymer (Celox (R)) in an experimental rat model with femoral artery bleeding. Materials and Methods: Thirty male Wistar albino rats weighing 200250 g were divided into 3 groups: control, Ankaferd, and chitosan. The femoral artery and vein were visualized and bleeding was started by an incision. The bleeding time was recorded and categorized as 'bleeding stopped at the second minute', 'bleeding stopped at the fourth minute', and 'unsuccessful' if bleeding continued after the fourth minute. Results: In the control group, 60% of the bleeding did not stop. In the first 4 min in the Ankaferd group, the bleeding stopped in all rats; only in 1 of the rats in the chitosan group did the bleeding not stop. In stopping the bleeding in the first 4 min, Ankaferd was similar to chitosan but better than the control group; the chitosan group was similar to the control, but the p-value was close to significance. Conclusion: For major arterial bleeding, the main treatment is surgical bleeding control, but outside of the hospital we can use buffers containing Ankaferd and chitosan on the bleeding region. The results of this study should be supported with larger studies. Furthermore, in our study, healthy rats were used. New studies are needed to evaluate the results of hypovolemic and hypotensive cases with major artery bleeding.

Eser Adı
[dc.title]
Comparison of the efficiencies of buffers containing ankaferd and chitosan on hemostasis in an experimental rat model with femoral artery bleeding
Yazar
[dc.contributor.author]
Abacıoğlu, Serkan
Yazar
[dc.contributor.author]
Aydın, Kemal
Yazar
[dc.contributor.author]
Büyükcam, Fatih
Yazar
[dc.contributor.author]
Kaya, Ural
Yazar
[dc.contributor.author]
Işık, Bahattin
Yazar
[dc.contributor.author]
Karakılıç, Muhammed Evvah
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
GALENOS YAYINCILIK
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: In the first assessment of trauma patients with major vascular injuries, we need effective and rapid-acting homeostatic materials. In this study we compare the efficiencies of Ankaferd Blood Stopper (R) and a chitosan linear polymer (Celox (R)) in an experimental rat model with femoral artery bleeding. Materials and Methods: Thirty male Wistar albino rats weighing 200250 g were divided into 3 groups: control, Ankaferd, and chitosan. The femoral artery and vein were visualized and bleeding was started by an incision. The bleeding time was recorded and categorized as 'bleeding stopped at the second minute', 'bleeding stopped at the fourth minute', and 'unsuccessful' if bleeding continued after the fourth minute. Results: In the control group, 60% of the bleeding did not stop. In the first 4 min in the Ankaferd group, the bleeding stopped in all rats; only in 1 of the rats in the chitosan group did the bleeding not stop. In stopping the bleeding in the first 4 min, Ankaferd was similar to chitosan but better than the control group; the chitosan group was similar to the control, but the p-value was close to significance. Conclusion: For major arterial bleeding, the main treatment is surgical bleeding control, but outside of the hospital we can use buffers containing Ankaferd and chitosan on the bleeding region. The results of this study should be supported with larger studies. Furthermore, in our study, healthy rats were used. New studies are needed to evaluate the results of hypovolemic and hypotensive cases with major artery bleeding.
Açıklama
[dc.description]
WOS: 000378165300008
Açıklama
[dc.description]
PubMed: 25913214
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bleeding
Konu Başlıkları
[dc.subject]
Ankaferd
Konu Başlıkları
[dc.subject]
Chitosan
Konu Başlıkları
[dc.subject]
Hemostasis
Künye
[dc.identifier.citation]
Abacioğlu, S., Aydin, K., Büyükcam, F., Kaya, U., Işik, B. ve Karakiliç, M. E. (2016). Comparison of the efficiencies of buffers containing ankaferd and chitosan on hemostasis in an experimental rat model with femoral artery bleeding. Turkish Journal of Hematology, 33(1), 48-52.
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1300-7777
ISSN
[dc.identifier.issn]
1308-5263
İlk Sayfa Sayısı
[dc.identifier.startpage]
48
Son Sayfa Sayısı
[dc.identifier.endpage]
52
Dergi Adı
[dc.relation.journal]
TURKISH JOURNAL OF HEMATOLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
33
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4274/tjh.2014.0029
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2287
Tek Biçim Adres
[dc.identifier.uri]
http://www.trdizin.gov.tr/publication/paper/detail/TVRrNU1UZzBOQT09
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bleeding chitosan Ankaferd control minute artery stopped femoral studies results similar fourth better stopping p-value significance Conclusion Objective arterial supported hypotensive hypovolemic evaluate needed healthy Furthermore larger should region containing buffers hospital outside surgical treatment
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