HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients

Objective: Uremic pruritus (UP) remains a frequent problem in hemodialysis (HD) patients and is related to mortality. Poor glycemic control, as evaluated by hemoglobin A1c (HbA1c), is also associated with morbidity and mortality in HD patients. In this study, we investigated the relationship between UP and HbA1c in HD patients. Methods: Sociodemographic, clinical, and laboratory variables, depressive symptoms, and health-related quality of life were assessed. Severity of UP was evaluated by visual analogue scale (VAS). The scale consisted of a 10 cm horizontal line marked from 0 (denoting no itch) to 10 (denoting worst possible imaginable itch). Results: Totally, 75 patients (male/female, 41/34; diabetic/nondiabetic, 29/46; age, 51.9 +/- 13.5 years) were included. The VAS pruritus score was higher in diabetic patients compared with nondiabetic patients (4.7 +/- 2.8 vs. 3.0 +/- 1.0, p : 0.015). In diabetics, VAS pruritus score was independently related with calcium-phosphorus product (beta : +0.637, p < 0.0001), intact parathyroid hormone (beta : +0.343, p : 0.017), HbA1c (beta : +0.310, p : 0.027), and Beck depression score (beta : +0.474, p : 0.002). In nondiabetics, VAS pruritus score was independently related with calcium-phosphorus product (beta: +0.486, p : 0.004), intact parathyroid hormone (beta : +0.302, p : 0.041), and HbA1c (beta : +0.341, p : 0.033). In the whole patient group, VAS pruritus score was independently related with calcium-phosphorus product (beta : +0.372, p : 0.001), intact parathyroid hormone (beta : +0.241, p : 0.008), HbA1c (beta : +0.227, p : 0.031), and Beck depression score (beta : +0.298, p : 0.003). Conclusions: In both diabetic and nondiabetic patients, HbA1c is closely related with pruritus in HD patients.

Dergi Adı RENAL FAILURE
Dergi Cilt Bilgisi 34
Dergi Sayısı 10
Sayfalar 1264 - 1269
Yayın Yılı 2012
Eser Adı
[dc.title]
HbA1c Is Related with Uremic Pruritus in Diabetic and Nondiabetic Hemodialysis Patients
Yazar
[dc.contributor.author]
Afsar, Baris
Yazar
[dc.contributor.author]
Afsar, Rengin Elsurer
Yayın Yılı
[dc.date.issued]
2012
Yayıncı
[dc.publisher]
INFORMA HEALTHCARE
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Uremic pruritus (UP) remains a frequent problem in hemodialysis (HD) patients and is related to mortality. Poor glycemic control, as evaluated by hemoglobin A1c (HbA1c), is also associated with morbidity and mortality in HD patients. In this study, we investigated the relationship between UP and HbA1c in HD patients. Methods: Sociodemographic, clinical, and laboratory variables, depressive symptoms, and health-related quality of life were assessed. Severity of UP was evaluated by visual analogue scale (VAS). The scale consisted of a 10 cm horizontal line marked from 0 (denoting no itch) to 10 (denoting worst possible imaginable itch). Results: Totally, 75 patients (male/female, 41/34; diabetic/nondiabetic, 29/46; age, 51.9 +/- 13.5 years) were included. The VAS pruritus score was higher in diabetic patients compared with nondiabetic patients (4.7 +/- 2.8 vs. 3.0 +/- 1.0, p : 0.015). In diabetics, VAS pruritus score was independently related with calcium-phosphorus product (beta : +0.637, p < 0.0001), intact parathyroid hormone (beta : +0.343, p : 0.017), HbA1c (beta : +0.310, p : 0.027), and Beck depression score (beta : +0.474, p : 0.002). In nondiabetics, VAS pruritus score was independently related with calcium-phosphorus product (beta: +0.486, p : 0.004), intact parathyroid hormone (beta : +0.302, p : 0.041), and HbA1c (beta : +0.341, p : 0.033). In the whole patient group, VAS pruritus score was independently related with calcium-phosphorus product (beta : +0.372, p : 0.001), intact parathyroid hormone (beta : +0.241, p : 0.008), HbA1c (beta : +0.227, p : 0.031), and Beck depression score (beta : +0.298, p : 0.003). Conclusions: In both diabetic and nondiabetic patients, HbA1c is closely related with pruritus in HD patients.
Açıklama
[dc.description]
WOS: 000310016300013
Açıklama
[dc.description]
PubMed: 21370992
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
depression
Konu Başlıkları
[dc.subject]
diabetes
Konu Başlıkları
[dc.subject]
hemoglobin A1c
Konu Başlıkları
[dc.subject]
pruritus
Konu Başlıkları
[dc.subject]
hemodialysis
Konu Başlıkları
[dc.subject]
quality of life
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0886-022X
İlk Sayfa Sayısı
[dc.identifier.startpage]
1264
Son Sayfa Sayısı
[dc.identifier.endpage]
1269
Dergi Adı
[dc.relation.journal]
RENAL FAILURE
Dergi Sayısı
[dc.identifier.issue]
10
Dergi Cilt Bilgisi
[dc.identifier.volume]
34
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3109/0886022X.2011.560401
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2701
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 16:54
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Tıklayınız
patients pruritus related hormone intact parathyroid product calcium-phosphorus independently (denoting nondiabetic diabetic depression evaluated mortality compared Conclusions higher closely included diabetics nondiabetics years) patient Objective possible (HbA1c) clinical Sociodemographic Methods between relationship investigated morbidity associated
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