Liver function tests in children and adolescents receiving risperidone treatment for a year: A longitudinal, observational study from Turkey

Objective. To determine the changes in liver function tests after long-term risperidone treatment in a child and adolescent population. Methods. Weight, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase and serum bilirubin of the patients were assessed in pre-treatment period, and at the sixth and 12th months of treatment. One hundred children and adolescents (aged between 3 and 18 years) were enrolled to the study. Results. Liver enzyme and bilirubin levels are higher than normal in 21.0% of the patients without clinical symptoms. No cases of hepatic failure or jaundice were seen. Only in an 8-year-old boy were there ALT level increases up to three-fold and AST level increases up to two-fold. After discontinuation of the risperidone treatment, enzyme levels were normalized in this patient. Alkaline phosphatase, alanine and aspartate aminotransferases were the most frequently increased enzymes. Conclusion. In this study, after long-term risperidone treatment of children and adolescents there was no evidence of clinically significant increases of liver enzymes and bilirubin levels. These results indicate that risperidone treatment may rarely cause serious liver enzyme increases, and may commonly cause clinically insignificant changes in liver function tests.

Yazar Karaman, Mehmet Goksin
ErdoGan, Ayten
Tufan, Evren
Yurteri, Nihal
Ozdemir, Esra
Ankarali, Handan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2890
Tek Biçim Adres 10.3109/13651501.2011.582537
Konu Başlıkları Risperidone
antipsychotics
ALP
AST
ALT
liver function tests
children
adolescents
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
Dergi Cilt Bilgisi 15
Dergi Sayısı 3
Sayfalar 204 - 208
Yayın Yılı 2011
Eser Adı
[dc.title]
Liver function tests in children and adolescents receiving risperidone treatment for a year: A longitudinal, observational study from Turkey
Yazar
[dc.contributor.author]
Karaman, Mehmet Goksin
Yazar
[dc.contributor.author]
ErdoGan, Ayten
Yazar
[dc.contributor.author]
Tufan, Evren
Yazar
[dc.contributor.author]
Yurteri, Nihal
Yazar
[dc.contributor.author]
Ozdemir, Esra
Yazar
[dc.contributor.author]
Ankarali, Handan
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
INFORMA HEALTHCARE
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective. To determine the changes in liver function tests after long-term risperidone treatment in a child and adolescent population. Methods. Weight, alanine aminotransferase, aspartate aminotransferase, gamma glutamyl transpeptidase, alkaline phosphatase and serum bilirubin of the patients were assessed in pre-treatment period, and at the sixth and 12th months of treatment. One hundred children and adolescents (aged between 3 and 18 years) were enrolled to the study. Results. Liver enzyme and bilirubin levels are higher than normal in 21.0% of the patients without clinical symptoms. No cases of hepatic failure or jaundice were seen. Only in an 8-year-old boy were there ALT level increases up to three-fold and AST level increases up to two-fold. After discontinuation of the risperidone treatment, enzyme levels were normalized in this patient. Alkaline phosphatase, alanine and aspartate aminotransferases were the most frequently increased enzymes. Conclusion. In this study, after long-term risperidone treatment of children and adolescents there was no evidence of clinically significant increases of liver enzymes and bilirubin levels. These results indicate that risperidone treatment may rarely cause serious liver enzyme increases, and may commonly cause clinically insignificant changes in liver function tests.
Açıklama
[dc.description]
WOS: 000293921600006
Açıklama
[dc.description]
PubMed: 22121930
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Risperidone
Konu Başlıkları
[dc.subject]
antipsychotics
Konu Başlıkları
[dc.subject]
ALP
Konu Başlıkları
[dc.subject]
AST
Konu Başlıkları
[dc.subject]
ALT
Konu Başlıkları
[dc.subject]
liver function tests
Konu Başlıkları
[dc.subject]
children
Konu Başlıkları
[dc.subject]
adolescents
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1365-1501
İlk Sayfa Sayısı
[dc.identifier.startpage]
204
Son Sayfa Sayısı
[dc.identifier.endpage]
208
Dergi Adı
[dc.relation.journal]
INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
15
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3109/13651501.2011.582537
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2890
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
20
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
11 Şubat 2024 10:39
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Tıklayınız
treatment increases risperidone bilirubin enzyme levels clinically aspartate phosphatase patients aminotransferase alanine enzymes children long-term function changes adolescents discontinuation two-fold Objective three-fold 8-year-old normalized patient significant insignificant commonly serious rarely indicate results evidence Alkaline jaundice
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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