Levels of serum IL-1 beta, IL-2, IL-8 and tumor necrosis factor-alpha in patients with unstable angina pectoris

Objectives: Inflammation is the most important mechanism of plaque disruption playing an essential role in acute coronary syndromes. It is controversial whether the inflammatory mediators are the cause or the result in the development of plaque rupture. Stimulation of interleukins increases adhesion molecules, fibrinogen and plasminogen activator inhibitors, which cause the activation of inflammation and thrombosis. However, the importance of interleukins in acute coronary syndromes has not been clearly defined. We did not find any article concerning relations between the levels of serum interleukin (IL)-1beta, IL-2, IL-8 and tumor necrosis factor (TNF)-alpha in patients with unstable angina pectoris (UAP). So the aim of this study was to determine the levels of serum IL-1beta, IL-2, IL-8 and TNF-alpha during the early stage of UAP. Methods and results: Thirty-seven patients with UAP (12 females and 25 males; mean age, 57.5 +/- 9.7 years) within 6 h of admission and 20 healthy volunteers (eight females and 12 males; mean age, 51.3 +/- 6.3 years) were included in the study. IL-1beta, IL-2, IL-8 and TNF-alpha levels were measured using the enzyme-linked immunosorbent assay method. Patients with acute or chronic inflammation, renal failure or chronic heart failure were excluded from the study. The age, gender and risk factors of the study and control groups were similar. The levels of IL-1beta, IL-8 and TNF-alpha were significantly increased (p < 0.0001, p < 0.001 and p < 0.016, respectively) in patients with UAP. There was no difference of IL-2 levels between the UAP group and controls. Conclusion: We detected high levels of IL-1 beta, IL-8 and TNF-alpha in patients with UAP during early phase. We suggest that proinflammatory cytokines (e. g. IL-1 beta, IL-8, TNF-alpha) may play an important role in the development of atherosclerosis and its complications.

Yazar Ozeren, A
Aydin, M
Tokac, M
Demircan, N
Unalacak, M
Gurel, A
Yazici, M
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2880
Tek Biçim Adres 10.1080/09629350310001633360
Konu Başlıkları unstable angina pectoris
inflammation
Interleukins
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MEDIATORS OF INFLAMMATION
Dergi Cilt Bilgisi 12
Dergi Sayısı 6
Sayfalar 361 - 365
Yayın Yılı 2003
Eser Adı
[dc.title]
Levels of serum IL-1 beta, IL-2, IL-8 and tumor necrosis factor-alpha in patients with unstable angina pectoris
Yazar
[dc.contributor.author]
Ozeren, A
Yazar
[dc.contributor.author]
Aydin, M
Yazar
[dc.contributor.author]
Tokac, M
Yazar
[dc.contributor.author]
Demircan, N
Yazar
[dc.contributor.author]
Unalacak, M
Yazar
[dc.contributor.author]
Gurel, A
Yazar
[dc.contributor.author]
Yazici, M
Yayın Yılı
[dc.date.issued]
2003
Yayıncı
[dc.publisher]
HINDAWI LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: Inflammation is the most important mechanism of plaque disruption playing an essential role in acute coronary syndromes. It is controversial whether the inflammatory mediators are the cause or the result in the development of plaque rupture. Stimulation of interleukins increases adhesion molecules, fibrinogen and plasminogen activator inhibitors, which cause the activation of inflammation and thrombosis. However, the importance of interleukins in acute coronary syndromes has not been clearly defined. We did not find any article concerning relations between the levels of serum interleukin (IL)-1beta, IL-2, IL-8 and tumor necrosis factor (TNF)-alpha in patients with unstable angina pectoris (UAP). So the aim of this study was to determine the levels of serum IL-1beta, IL-2, IL-8 and TNF-alpha during the early stage of UAP. Methods and results: Thirty-seven patients with UAP (12 females and 25 males; mean age, 57.5 +/- 9.7 years) within 6 h of admission and 20 healthy volunteers (eight females and 12 males; mean age, 51.3 +/- 6.3 years) were included in the study. IL-1beta, IL-2, IL-8 and TNF-alpha levels were measured using the enzyme-linked immunosorbent assay method. Patients with acute or chronic inflammation, renal failure or chronic heart failure were excluded from the study. The age, gender and risk factors of the study and control groups were similar. The levels of IL-1beta, IL-8 and TNF-alpha were significantly increased (p < 0.0001, p < 0.001 and p < 0.016, respectively) in patients with UAP. There was no difference of IL-2 levels between the UAP group and controls. Conclusion: We detected high levels of IL-1 beta, IL-8 and TNF-alpha in patients with UAP during early phase. We suggest that proinflammatory cytokines (e. g. IL-1 beta, IL-8, TNF-alpha) may play an important role in the development of atherosclerosis and its complications.
Açıklama
[dc.description]
WOS: 000187065100006
Açıklama
[dc.description]
PubMed: 14668096
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
unstable angina pectoris
Konu Başlıkları
[dc.subject]
inflammation
Konu Başlıkları
[dc.subject]
Interleukins
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0962-9351
ISSN
[dc.identifier.issn]
1466-1861
İlk Sayfa Sayısı
[dc.identifier.startpage]
361
Son Sayfa Sayısı
[dc.identifier.endpage]
365
Dergi Adı
[dc.relation.journal]
MEDIATORS OF INFLAMMATION
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
12
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/09629350310001633360
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2880
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 23:18
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levels TNF-alpha patients IL-1beta during failure inflammation between chronic females important interleukins coronary syndromes plaque development years) volunteers healthy immunosorbent Patients method (eight enzyme-linked measured included increased excluded suggest proinflammatory cytokines Conclusion TNF-alpha) atherosclerosis complications
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