Histopathological Effects of Fibrin Glue and Cyanoacrylate on the Maxillary Sinus

Objective: To compare the histopathological effects of fibrin glue (FbGl) and cyanoacrylate (CyAc) on the maxillary sinus mucosa. Methods: Twenty rabbits were divided into two groups of 10, and surgical defects were created in the maxillary sinuses. The right maxillary sinus was treated with FbGl in one group and with CyAc in the other group. As a control, the left maxillary sinuses of all rabbits were treated with sterile saline solution. One rabbit treated with CyAc died during the study and was excluded. On postoperative day 21, all animals were sacrificed. Maxillary sinus mucosa samples were studied to determine the extent of inflammation and fibrosis, foreign body reaction, cilia loss, increased osteogenesis in bony structures under the mucosa, and loss of serous glands. Results: The FbGl group differed significantly from the CyAc and control groups in terms of a high degree of inflammation (p<0.001), fibrosis (p<0.001), foreign body reaction (p<0.001), cilia loss (p<0.001), and serous gland loss (p<0.001). In terms of osteogenesis, there were no significant differences between the FbGl and CyAc groups (p=0.650), while there was a significant (p=0.002) difference between these two groups and the control group. Conclusion: Histopathologically, CyAc had fewer side effects than FbGl. Further clinical studies are needed to demonstrate the validity of these results in humans.

Yazar Sarikaya, Selda
Biskin, Sultan
Damar, Murat
Ugur, Mehmet Birol
Sakalli, Erdal
Bektas, Sibel
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2726
Tek Biçim Adres 10.5152/tao.2016.1590
Konu Başlıkları Animal experimentation
maxillary sinus
fibrin glue
cyanoacrylate
histopathology
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY-TURK OTORINOLARENGOLOJI ARSIVI
Dergi Cilt Bilgisi 54
Dergi Sayısı 2
Sayfalar 63 - 68
Yayın Yılı 2016
Eser Adı
[dc.title]
Histopathological Effects of Fibrin Glue and Cyanoacrylate on the Maxillary Sinus
Yazar
[dc.contributor.author]
Sarikaya, Selda
Yazar
[dc.contributor.author]
Biskin, Sultan
Yazar
[dc.contributor.author]
Damar, Murat
Yazar
[dc.contributor.author]
Ugur, Mehmet Birol
Yazar
[dc.contributor.author]
Sakalli, Erdal
Yazar
[dc.contributor.author]
Bektas, Sibel
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
AVES
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: To compare the histopathological effects of fibrin glue (FbGl) and cyanoacrylate (CyAc) on the maxillary sinus mucosa. Methods: Twenty rabbits were divided into two groups of 10, and surgical defects were created in the maxillary sinuses. The right maxillary sinus was treated with FbGl in one group and with CyAc in the other group. As a control, the left maxillary sinuses of all rabbits were treated with sterile saline solution. One rabbit treated with CyAc died during the study and was excluded. On postoperative day 21, all animals were sacrificed. Maxillary sinus mucosa samples were studied to determine the extent of inflammation and fibrosis, foreign body reaction, cilia loss, increased osteogenesis in bony structures under the mucosa, and loss of serous glands. Results: The FbGl group differed significantly from the CyAc and control groups in terms of a high degree of inflammation (p<0.001), fibrosis (p<0.001), foreign body reaction (p<0.001), cilia loss (p<0.001), and serous gland loss (p<0.001). In terms of osteogenesis, there were no significant differences between the FbGl and CyAc groups (p=0.650), while there was a significant (p=0.002) difference between these two groups and the control group. Conclusion: Histopathologically, CyAc had fewer side effects than FbGl. Further clinical studies are needed to demonstrate the validity of these results in humans.
Açıklama
[dc.description]
WOS: 000383169700005
Açıklama
[dc.description]
PubMed: 29392019
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Animal experimentation
Konu Başlıkları
[dc.subject]
maxillary sinus
Konu Başlıkları
[dc.subject]
fibrin glue
Konu Başlıkları
[dc.subject]
cyanoacrylate
Konu Başlıkları
[dc.subject]
histopathology
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2149-3987
ISSN
[dc.identifier.issn]
2149-553X
İlk Sayfa Sayısı
[dc.identifier.startpage]
63
Son Sayfa Sayısı
[dc.identifier.endpage]
68
Dergi Adı
[dc.relation.journal]
TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY-TURK OTORINOLARENGOLOJI ARSIVI
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
54
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5152/tao.2016.1590
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2726
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
18
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 22:26
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maxillary groups treated control mucosa serous between reaction osteogenesis effects foreign fibrosis sinuses rabbits inflammation significant degree Objective significantly Results glands structures differed humans results validity demonstrate needed studies clinical Further Histopathologically Conclusion difference differences
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