Effects of the folk medicinal plant extract Ankaferd Blood Stopper (R) on the ocular surface

Purpose: To investigate the effects of Ankaferd Blood Stopper (R) (ABS) on the ocular surface. Methods: Twenty adult male Wistar albino rats, weighing 390-530 g, were used in this prospective, controlled trial. One drop of ABS and one drop of balanced salt solution (BSS) were instilled into the lower conjunctival sac of the right and left eyes, respectively. After the rats were anesthetized, the ocular surface was evaluated based on the Draize criteria, and fluorescein tests were performed at 1, 2, 4, 18, 24, and 48 h. Subsequently, the rats were killed and all eyes were enucleated for histopathological examination. Results: The outcome of the Draize and fluorescein tests revealed that ABS caused more irritation of the ocular surface than BSS (P < 0.001). The highest mean ABS score was 4.9 for the Draize test and 0.4 for the fluorescein test, and ABS was considered to be a slight irritant. Histopathological examinations of the cornea and the conjunctiva revealed no significant difference between the eyes instilled with BSS and those instilled with ABS. Conclusions: ABS is a hemostatic drug that exerts a slight toxic effect on the ocular surface. Given its ease of use and antibacterial activity, as well as its efficiency in stopping bleeding, the use of ABS during ocular surgery should be further investigated in experimental and clinical studies.

Yazar Alpay, Atilla
Evren, Cenk
Bektas, Sibel
Ugurbas, Silay Canturk
Ugurbas, Suat Hayri
Cinar, Fikret
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2514
Tek Biçim Adres 10.3109/15569527.2011.565011
Konu Başlıkları Ankaferd Blood Stopper (R)
cornea
conjunctiva
Draize test
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı CUTANEOUS AND OCULAR TOXICOLOGY
Dergi Cilt Bilgisi 30
Dergi Sayısı 4
Sayfalar 280 - 285
Yayın Yılı 2011
Eser Adı
[dc.title]
Effects of the folk medicinal plant extract Ankaferd Blood Stopper (R) on the ocular surface
Yazar
[dc.contributor.author]
Alpay, Atilla
Yazar
[dc.contributor.author]
Evren, Cenk
Yazar
[dc.contributor.author]
Bektas, Sibel
Yazar
[dc.contributor.author]
Ugurbas, Silay Canturk
Yazar
[dc.contributor.author]
Ugurbas, Suat Hayri
Yazar
[dc.contributor.author]
Cinar, Fikret
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
INFORMA HEALTHCARE
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Purpose: To investigate the effects of Ankaferd Blood Stopper (R) (ABS) on the ocular surface. Methods: Twenty adult male Wistar albino rats, weighing 390-530 g, were used in this prospective, controlled trial. One drop of ABS and one drop of balanced salt solution (BSS) were instilled into the lower conjunctival sac of the right and left eyes, respectively. After the rats were anesthetized, the ocular surface was evaluated based on the Draize criteria, and fluorescein tests were performed at 1, 2, 4, 18, 24, and 48 h. Subsequently, the rats were killed and all eyes were enucleated for histopathological examination. Results: The outcome of the Draize and fluorescein tests revealed that ABS caused more irritation of the ocular surface than BSS (P < 0.001). The highest mean ABS score was 4.9 for the Draize test and 0.4 for the fluorescein test, and ABS was considered to be a slight irritant. Histopathological examinations of the cornea and the conjunctiva revealed no significant difference between the eyes instilled with BSS and those instilled with ABS. Conclusions: ABS is a hemostatic drug that exerts a slight toxic effect on the ocular surface. Given its ease of use and antibacterial activity, as well as its efficiency in stopping bleeding, the use of ABS during ocular surgery should be further investigated in experimental and clinical studies.
Açıklama
[dc.description]
WOS: 000296498200004
Açıklama
[dc.description]
PubMed: 21425951
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Ankaferd Blood Stopper (R)
Konu Başlıkları
[dc.subject]
cornea
Konu Başlıkları
[dc.subject]
conjunctiva
Konu Başlıkları
[dc.subject]
Draize test
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1556-9527
İlk Sayfa Sayısı
[dc.identifier.startpage]
280
Son Sayfa Sayısı
[dc.identifier.endpage]
285
Dergi Adı
[dc.relation.journal]
CUTANEOUS AND OCULAR TOXICOLOGY
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
30
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3109/15569527.2011.565011
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2514
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
2
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Eylül 2023 16:45
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Tıklayınız
ocular surface instilled fluorescein Draize slight revealed highest considered irritation irritant Histopathological examinations Purpose cornea activity studies clinical experimental investigated further should surgery during bleeding stopping efficiency antibacterial conjunctiva effect exerts hemostatic Conclusions between difference
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