Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting

Objective: This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus. Methods: Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic characteristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared. Results: Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively. Conclusion: Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery.

Yazar Furat, Cevdet
Dogan, Riza
Ilhan, Gokhan
Bayar, Ekrem
Ozpak, Berkan
Kara, Hakan
Bozok, Sahin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3435
Tek Biçim Adres 10.5830/CVJA-2016-089
Konu Başlıkları telmisartan
coronary artery bypass grafting
diabetes mellitus
microalbuminuria
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı CARDIOVASCULAR JOURNAL OF AFRICA
Dergi Cilt Bilgisi 28
Dergi Sayısı 3
Sayfalar 191 - 195
Yayın Yılı 2017
Eser Adı
[dc.title]
Telmisartan decreases microalbuminuria in patients with type 2 diabetes mellitus following coronary artery bypass grafting
Yazar
[dc.contributor.author]
Furat, Cevdet
Yazar
[dc.contributor.author]
Dogan, Riza
Yazar
[dc.contributor.author]
Ilhan, Gokhan
Yazar
[dc.contributor.author]
Bayar, Ekrem
Yazar
[dc.contributor.author]
Ozpak, Berkan
Yazar
[dc.contributor.author]
Kara, Hakan
Yazar
[dc.contributor.author]
Bozok, Sahin
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
CLINICS CARDIVE PUBL PTY LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: This prospective study aimed to investigate the effects of the selective angiotensin receptor antagonist, telmisartan, on microalbuminuria after coronary artery bypass surgery in patients with diabetes mellitus. Methods: Patients were divided into two groups with block randomisation, using the sealed envelope technique: group T (telmisartan group) consisted of patients who received the angiotensin receptor blocking agent telmisartan 80 mg daily for at least six months in the pre-operative period; group N-T (non-telmisartan group) consisted of patients who received no telmisartan treatment. Clinical and demographic characteristics, operative and postoperative features, microalbuminuria and high-sensitivity C-reactive protein levels were compared. Results: Forty patients met the eligibility criteria for the study. The groups did not differ with regard to clinical and demographic characteristics, and operative and postoperative features. Microalbuminuria levels between the groups differed significantly in the pre-operative period, first hour postoperatively and fifth day postoperatively. C-reactive protein levels between the groups differed significantly on the fifth day postoperatively. Conclusion: Telmisartan was useful for decreasing systemic inflammation and levels of urinary albumin excretion in patients who had type 2 diabetes mellitus and had undergone coronary artery bypass surgery.
Açıklama
[dc.description]
WOS: 000405948700013
Açıklama
[dc.description]
PubMed: 27834982
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
telmisartan
Konu Başlıkları
[dc.subject]
coronary artery bypass grafting
Konu Başlıkları
[dc.subject]
diabetes mellitus
Konu Başlıkları
[dc.subject]
microalbuminuria
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1995-1892
ISSN
[dc.identifier.issn]
1680-0745
İlk Sayfa Sayısı
[dc.identifier.startpage]
191
Son Sayfa Sayısı
[dc.identifier.endpage]
195
Dergi Adı
[dc.relation.journal]
CARDIOVASCULAR JOURNAL OF AFRICA
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
28
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5830/CVJA-2016-089
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3435
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
14
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 06:12
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Tıklayınız
patients levels groups telmisartan postoperatively significantly differed group) consisted protein received between pre-operative period demographic characteristics operative postoperative features C-reactive artery diabetes microalbuminuria coronary angiotensin bypass surgery mellitus receptor eligibility criteria useful Results excretion compared
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