Tumor Necrosis Factor-Alpha (TNF-alpha-308G > A) Polymorphism in High-grade Gliomas

Background/Aim: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligo-dendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-alpha -308 G>A polymorphism in a Turkish population. Patients and Methods: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. Results: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). Conclusion: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities.

Yazar Ozdogan, Selcuk
Yaltirik, Cumhur Kaan
Yilmaz, Seda Gulec
Kaya, Mustafa
Duzkalir, Ali Haluk
Demirel, Nail
Kafadar, Ali
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3730
Tek Biçim Adres 10.21873/invivo.11236
Konu Başlıkları Tumor necrosis factor
polymorphism
high-grade gliomas
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı IN VIVO
Dergi Cilt Bilgisi 32
Dergi Sayısı 2
Sayfalar 287 - 289
Yayın Yılı 2018
Eser Adı
[dc.title]
Tumor Necrosis Factor-Alpha (TNF-alpha-308G > A) Polymorphism in High-grade Gliomas
Yazar
[dc.contributor.author]
Ozdogan, Selcuk
Yazar
[dc.contributor.author]
Yaltirik, Cumhur Kaan
Yazar
[dc.contributor.author]
Yilmaz, Seda Gulec
Yazar
[dc.contributor.author]
Kaya, Mustafa
Yazar
[dc.contributor.author]
Duzkalir, Ali Haluk
Yazar
[dc.contributor.author]
Demirel, Nail
Yazar
[dc.contributor.author]
Kafadar, Ali
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
INT INST ANTICANCER RESEARCH
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/Aim: High-grade gliomas (HGG) consist of anaplastic oligoastrocytomas, anaplastic oligo-dendrogliomas, anaplastic astrocytomas and glioblastoma multiforme. The present study aimed to evaluate TNF-alpha -308 G>A polymorphism in a Turkish population. Patients and Methods: This was a prospective case-control study that included 45 patients with HGG and 49 healthy individuals. All patients were operated for intracranial tumors and the pathology results consist of high grade (Grade3 and 4) glial tumors. Results: No significant differences were found between the HGG and control groups in terms of the median age (p=0.898). There were no significant differences with regard to gender (p=0.577). The TNF genotype frequency comparison between patients and controls was not statistically significant (p=0.598). Conclusion: TNF genotype frequency comparison between the patients and controls was not statistically significant in the Turkish population tested. However, further studies are needed to evaluate the genotype and phenotype correlations in large cohorts of various ethnicities.
Açıklama
[dc.description]
WOS: 000426048600010
Açıklama
[dc.description]
PubMed: 29475911
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Tumor necrosis factor
Konu Başlıkları
[dc.subject]
polymorphism
Konu Başlıkları
[dc.subject]
high-grade gliomas
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0258-851X
ISSN
[dc.identifier.issn]
1791-7549
İlk Sayfa Sayısı
[dc.identifier.startpage]
287
Son Sayfa Sayısı
[dc.identifier.endpage]
289
Dergi Adı
[dc.relation.journal]
IN VIVO
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
32
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.21873/invivo.11236
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3730
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
9
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 16:12
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Tıklayınız
patients significant genotype anaplastic between population controls tumors comparison frequency Turkish statistically consist differences evaluate ethnicities control groups median various cohorts Conclusion further gender correlations phenotype needed tested studies However regard Background/Aim present Methods Patients
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