Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion

Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. Oral administration of rosiglitazone (1.5, 3, and 6 mg/kg/day) or vehicle was carried out for 5 weeks, starting one week before the surgery. Cognitive performance was assessed using the Morris water maze. The density of S100B protein-immunoreactive astrocytes and the OX-42-labeled microglial activation were estimated. Synaptogenesis was also evaluated by the measurement of synaptophysin, the pre-synaptic vesicular protein, level via western blotting technique. Cerebral hypoperfusion for 30 days induced a significant cognitive impairment along with hyperactivation of both microglial and astroglial cells, and reduction of synaptophysin level. Rosiglitazone treatment (3 and 6 mg/kg) not only suppressed the activation of astrocytes and microglia markedly but also alleviated the impairment of memory and increased the synaptophysin level. In conclusion, our results suggest that the chronic administration of rosiglitazone significantly prevents chronic cerebral hypoperfusion-induced brain damage, at least, partly through suppressing glial activation and preserving synaptic plasticity. Thus, it appears that rosiglitazone may be a promising pharmacological agent in the development of therapeutic approaches for the prevention or treatment of cerebrovascular diseases.

Yazar Sayan-Ozacmak, Hale
Ozacmak, V. Haktan
Barut, Figen
Jakubowska-Dogru, Ewa
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2991
Tek Biçim Adres 10.2174/156720211796558087
Konu Başlıkları Chronic cerebral hypoperfusion
S100
synaptophysin
spatial learning
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı CURRENT NEUROVASCULAR RESEARCH
Dergi Cilt Bilgisi 8
Dergi Sayısı 3
Sayfalar 190 - 199
Yayın Yılı 2011
Eser Adı
[dc.title]
Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor-gamma Ligand in Chronic Cerebral Hypoperfusion
Yazar
[dc.contributor.author]
Sayan-Ozacmak, Hale
Yazar
[dc.contributor.author]
Ozacmak, V. Haktan
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Jakubowska-Dogru, Ewa
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
BENTHAM SCIENCE PUBL LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Chronic cerebral hypoperfusion can cause learning and memory impairment and neuronal damage resembling the effects observed in vascular dementia. PPAR-gamma agonists were shown to modulate inflammatory response and neuronal death following cerebral ischemia. The present study was designed to evaluate possible neuroprotective effects of rosiglitazone, a PPAR-gamma agonist, in rat model of chronic cerebral hypoperfusion. Cerebral hypoperfusion was induced by permanent bilateral occlusion of the common carotid arteries. Oral administration of rosiglitazone (1.5, 3, and 6 mg/kg/day) or vehicle was carried out for 5 weeks, starting one week before the surgery. Cognitive performance was assessed using the Morris water maze. The density of S100B protein-immunoreactive astrocytes and the OX-42-labeled microglial activation were estimated. Synaptogenesis was also evaluated by the measurement of synaptophysin, the pre-synaptic vesicular protein, level via western blotting technique. Cerebral hypoperfusion for 30 days induced a significant cognitive impairment along with hyperactivation of both microglial and astroglial cells, and reduction of synaptophysin level. Rosiglitazone treatment (3 and 6 mg/kg) not only suppressed the activation of astrocytes and microglia markedly but also alleviated the impairment of memory and increased the synaptophysin level. In conclusion, our results suggest that the chronic administration of rosiglitazone significantly prevents chronic cerebral hypoperfusion-induced brain damage, at least, partly through suppressing glial activation and preserving synaptic plasticity. Thus, it appears that rosiglitazone may be a promising pharmacological agent in the development of therapeutic approaches for the prevention or treatment of cerebrovascular diseases.
Açıklama
[dc.description]
WOS: 000294411200002
Açıklama
[dc.description]
PubMed: 21675957
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Chronic cerebral hypoperfusion
Konu Başlıkları
[dc.subject]
S100
Konu Başlıkları
[dc.subject]
synaptophysin
Konu Başlıkları
[dc.subject]
spatial learning
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1567-2026
Sponsor YAYINCI
[dc.description.sponsorship]
Turkish Scientific Research Council (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [108S114, SBAG-HD-303]
Sponsor YAYINCI
[dc.description.sponsorship]
We have gratefully acknowledged the Research Projects Fund of Turkish Scientific Research Council (TUBITAK) for providing financial support that made the present study possible (the grant # 108S114, SBAG-HD-303).
İlk Sayfa Sayısı
[dc.identifier.startpage]
190
Son Sayfa Sayısı
[dc.identifier.endpage]
199
Dergi Adı
[dc.relation.journal]
CURRENT NEUROVASCULAR RESEARCH
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
8
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.2174/156720211796558087
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2991
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
17 Nisan 2024 15:21
Google Kontrol
Tıklayınız
hypoperfusion cerebral rosiglitazone activation synaptophysin impairment chronic treatment Cerebral astrocytes induced administration effects PPAR-gamma neuronal memory damage microglial blotting microglia western suppressed alleviated markedly cognitive technique significant Rosiglitazone reduction astroglial hyperactivation mg/kg) Chronic increased plasticity
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms