Is osteoporosis generalized or localized to central skele-ton in ankylosing spondylitis?

Background: Osteoporosis at the lumbar spine and at the femur is a well-established complication in ankylosing spondylitis (AS), but the exact mechanism and the distribution of osteoporosis are not known absolutely. Objective: To determine whether the osteoporosis is generalized or localized to central skeleton and to examine the relation between bone mineral density (BMD) and disease activity and radiologic progression in patients with AS. Methods: In this study, 26 patients with AS and 33 healthy controls matched for age and sex were recruited to the study. Hip and forearm BMD were measured by dual energy X-ray absorptiometry (DEXA). Laboratory and clinical disease activity parameters were documented, and anteroposterior sacroiliac radiographs were taken to determine the radiologic progression. Results: The urine deoxypyridinoline levels of the patients with AS were statistically significantly higher (P = 0.02) and the serum osteocalcin levels were significantly lower with respect to controls (P = 0.03). The femoral neck and femur BMD values and T scores were significantly lower in patients with AS compared with the controls (P = 0.019, 0.003, 0.01, and 0.01, respectively). The differences in BMD values and T scores of the distal 1/3 radius between 2 groups were not statistically significant. The relation between BMD and disease activity, and radiologic progression in patients with AS could not detected. Conclusion: Sparing of distal regions such as the as radius suggests that osteoporosis might be due to localized effects of inflammatory activity or immobility rather than a systemic effect. Both increased resorption and decreased formation might be involved in the pathogenesis of osteoporosis. Radius BMD may not be appropriate to evaluate bone loss in patients with AS.

Yazar Sarikaya, Selda
Basaran, Aynur
Tekin, Yasin
Ozdolap, Senay
Ortancil, Ozgur
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2851
Tek Biçim Adres 10.1097/01.rhu.0000255688.83037.42
Konu Başlıkları ankylosing spondylitis
osteoporosis
central skeleton
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
Dergi Cilt Bilgisi 13
Dergi Sayısı 1
Sayfalar 20 - 24
Yayın Yılı 2007
Eser Adı
[dc.title]
Is osteoporosis generalized or localized to central skele-ton in ankylosing spondylitis?
Yazar
[dc.contributor.author]
Sarikaya, Selda
Yazar
[dc.contributor.author]
Basaran, Aynur
Yazar
[dc.contributor.author]
Tekin, Yasin
Yazar
[dc.contributor.author]
Ozdolap, Senay
Yazar
[dc.contributor.author]
Ortancil, Ozgur
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
LIPPINCOTT WILLIAMS & WILKINS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Osteoporosis at the lumbar spine and at the femur is a well-established complication in ankylosing spondylitis (AS), but the exact mechanism and the distribution of osteoporosis are not known absolutely. Objective: To determine whether the osteoporosis is generalized or localized to central skeleton and to examine the relation between bone mineral density (BMD) and disease activity and radiologic progression in patients with AS. Methods: In this study, 26 patients with AS and 33 healthy controls matched for age and sex were recruited to the study. Hip and forearm BMD were measured by dual energy X-ray absorptiometry (DEXA). Laboratory and clinical disease activity parameters were documented, and anteroposterior sacroiliac radiographs were taken to determine the radiologic progression. Results: The urine deoxypyridinoline levels of the patients with AS were statistically significantly higher (P = 0.02) and the serum osteocalcin levels were significantly lower with respect to controls (P = 0.03). The femoral neck and femur BMD values and T scores were significantly lower in patients with AS compared with the controls (P = 0.019, 0.003, 0.01, and 0.01, respectively). The differences in BMD values and T scores of the distal 1/3 radius between 2 groups were not statistically significant. The relation between BMD and disease activity, and radiologic progression in patients with AS could not detected. Conclusion: Sparing of distal regions such as the as radius suggests that osteoporosis might be due to localized effects of inflammatory activity or immobility rather than a systemic effect. Both increased resorption and decreased formation might be involved in the pathogenesis of osteoporosis. Radius BMD may not be appropriate to evaluate bone loss in patients with AS.
Açıklama
[dc.description]
WOS: 000246852100005
Açıklama
[dc.description]
PubMed: 17278944
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
ankylosing spondylitis
Konu Başlıkları
[dc.subject]
osteoporosis
Konu Başlıkları
[dc.subject]
central skeleton
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1076-1608
İlk Sayfa Sayısı
[dc.identifier.startpage]
20
Son Sayfa Sayısı
[dc.identifier.endpage]
24
Dergi Adı
[dc.relation.journal]
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
13
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/01.rhu.0000255688.83037.42
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2851
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 07:12
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patients osteoporosis activity significantly radiologic disease between controls progression relation distal scores values radius localized statistically determine levels respect differences respectively) evaluate femoral compared osteocalcin appropriate systemic decreased rather immobility inflammatory effects effect increased suggests
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