Expression of monocyte and lymphocyte adhesion molecules is increased in isolated coronary artery ectasia

Background Coronary artery ectasia is defined as localized or diffuse dilation of the coronary arteries exceeding the 1.5-fold of normal adjacent segment. Scarce data are available about the role of inflammation in coronary artery ectasia. In the present study, we aimed to evaluate the expression of CD11b and CD45 adhesion molecules in peripheral blood granulocytes, monocytes and lymphocytes from the patients with coronary artery ectasia as possible indicators of inflammation. Method The study consisted of 14 patients who had angiographically normal coronary arteries with coronary artery ectasia and 13 age and sex-matched controls without coronary artery ectasia. Cell surface adhesion molecules were detected by direct immunofluorescence evaluated by flow cytometry using monoclonal antibodies tagged with fluorescent markers. Venous blood samples were taken after coronary angiography. Results Mean fluorescence intensity of CD45 (33.8 +/- 3.1 vs. 13.0 +/- 0.7, P < 0.001) and CD11b (39.1 +/- 13.5 vs. 19.5 +/- 1.32, P < 0.001) on the monocyte surface of patients with coronary artery ectasia were higher than those of controls. Similarly in patients with coronary artery ectasia, the expression of CD11b (7.5 +/- 0.61 vs. 5.6 +/- 0.2, P=0.009) and CD45 (475 +/- 3.6 vs. 36.2 +/- 2.5, P=0.02) on lymphocytes was also significantly higher than those of controls. Conclusion Increased levels of cellular adhesion molecules in patients with coronary artery ectasia may be an indicator of endothelial activation and inflammation and are likely to be in the causal pathway leading to coronary artery ectasia.

Yazar Yildirim, Nesligul
Tekin, Ishak O.
Dogan, Sait M.
Aydin, Mustafa
Gursurer, Metin
Cam, Fatih
Gungorduk, Alper
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2628
Tek Biçim Adres 10.1097/MCA.0b013e32801104d4
Konu Başlıkları cellular adhesion molecules
coronary artery ectasia
inflammation
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı CORONARY ARTERY DISEASE
Dergi Cilt Bilgisi 18
Dergi Sayısı 1
Sayfalar 49 - 53
Yayın Yılı 2007
Eser Adı
[dc.title]
Expression of monocyte and lymphocyte adhesion molecules is increased in isolated coronary artery ectasia
Yazar
[dc.contributor.author]
Yildirim, Nesligul
Yazar
[dc.contributor.author]
Tekin, Ishak O.
Yazar
[dc.contributor.author]
Dogan, Sait M.
Yazar
[dc.contributor.author]
Aydin, Mustafa
Yazar
[dc.contributor.author]
Gursurer, Metin
Yazar
[dc.contributor.author]
Cam, Fatih
Yazar
[dc.contributor.author]
Gungorduk, Alper
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
LIPPINCOTT WILLIAMS & WILKINS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background Coronary artery ectasia is defined as localized or diffuse dilation of the coronary arteries exceeding the 1.5-fold of normal adjacent segment. Scarce data are available about the role of inflammation in coronary artery ectasia. In the present study, we aimed to evaluate the expression of CD11b and CD45 adhesion molecules in peripheral blood granulocytes, monocytes and lymphocytes from the patients with coronary artery ectasia as possible indicators of inflammation. Method The study consisted of 14 patients who had angiographically normal coronary arteries with coronary artery ectasia and 13 age and sex-matched controls without coronary artery ectasia. Cell surface adhesion molecules were detected by direct immunofluorescence evaluated by flow cytometry using monoclonal antibodies tagged with fluorescent markers. Venous blood samples were taken after coronary angiography. Results Mean fluorescence intensity of CD45 (33.8 +/- 3.1 vs. 13.0 +/- 0.7, P < 0.001) and CD11b (39.1 +/- 13.5 vs. 19.5 +/- 1.32, P < 0.001) on the monocyte surface of patients with coronary artery ectasia were higher than those of controls. Similarly in patients with coronary artery ectasia, the expression of CD11b (7.5 +/- 0.61 vs. 5.6 +/- 0.2, P=0.009) and CD45 (475 +/- 3.6 vs. 36.2 +/- 2.5, P=0.02) on lymphocytes was also significantly higher than those of controls. Conclusion Increased levels of cellular adhesion molecules in patients with coronary artery ectasia may be an indicator of endothelial activation and inflammation and are likely to be in the causal pathway leading to coronary artery ectasia.
Açıklama
[dc.description]
WOS: 000243547800008
Açıklama
[dc.description]
PubMed: 17172930
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
cellular adhesion molecules
Konu Başlıkları
[dc.subject]
coronary artery ectasia
Konu Başlıkları
[dc.subject]
inflammation
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0954-6928
ISSN
[dc.identifier.issn]
1473-5830
İlk Sayfa Sayısı
[dc.identifier.startpage]
49
Son Sayfa Sayısı
[dc.identifier.endpage]
53
Dergi Adı
[dc.relation.journal]
CORONARY ARTERY DISEASE
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
18
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1097/MCA.0b013e32801104d4
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2628
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
21
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 19:49
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Tıklayınız
coronary artery ectasia patients controls adhesion molecules inflammation lymphocytes arteries expression higher normal surface Results fluorescence intensity Background monocyte levels leading pathway causal likely activation endothelial indicator cellular Increased Similarly Conclusion significantly angiography detected available
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