Multiparametric or practical quantitative liver MRI: towards millisecond, fat fraction, kilopascal and function era

Introduction: New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620ms for 1.5T and 700-850ms for 3T), T2, T2* (>20ms), T1rho (40-50ms) mapping, proton density fat fraction (PDFF) (5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%). T1 mapping can be important for the assessment of fibrosis, amyloidosis and copper overload. T1rho mapping is promising for the assessment of liver collagen deposition. PDFF can allow objective treatment assessment in NAFLD and NASH patients. T2 and T2* are used for iron overload determination. MR fingerprinting may enable single slice acquisition and easy implementation of multiparametric MRI and follow-up of patients.Areas covered: T1, T2, T2*, PDFF and stiffness, diffusion weighted imaging, intravoxel incoherent motion imaging (ADC, D, D* and f values) and function analysis are reviewed.Expert commentary: Multiparametric MRI can enable biopsyless diagnosis and more objective staging of diffuse liver disease, cirrhosis and predisposing diseases. A comprehensive approach is needed to understand and overcome the effects of iron, fat, fibrosis, edema, inflammation and copper on MR relaxometry values in diffuse liver disease.

Yazar Unal, Emre
Idilman, Ilkay Sedakat
Karcaaltincaba, Musturay
Yayın Türü Review
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2965
Tek Biçim Adres 10.1080/17474124.2017.1271710
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Sayfalar 167 - 182
Yayın Yılı 2017
Eser Adı
[dc.title]
Multiparametric or practical quantitative liver MRI: towards millisecond, fat fraction, kilopascal and function era
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS LTD
Yayın Türü
[dc.type]
review
Açıklama
[dc.description]
WOS: 000393777000009
Açıklama
[dc.description]
PubMed: 27937040
Özet
[dc.description.abstract]
Introduction: New advances in liver magnetic resonance imaging (MRI) may enable diagnosis of unseen pathologies by conventional techniques. Normal T1 (550-620ms for 1.5T and 700-850ms for 3T), T2, T2* (>20ms), T1rho (40-50ms) mapping, proton density fat fraction (PDFF) (5%) and stiffness (2-3kPa) values can enable differentiation of a normal liver from chronic liver and diffuse diseases. Gd-EOB-DTPA can enable assessment of liver function by using postcontrast hepatobiliary phase or T1 reduction rate (normally above 60%). T1 mapping can be important for the assessment of fibrosis, amyloidosis and copper overload. T1rho mapping is promising for the assessment of liver collagen deposition. PDFF can allow objective treatment assessment in NAFLD and NASH patients. T2 and T2* are used for iron overload determination. MR fingerprinting may enable single slice acquisition and easy implementation of multiparametric MRI and follow-up of patients.Areas covered: T1, T2, T2*, PDFF and stiffness, diffusion weighted imaging, intravoxel incoherent motion imaging (ADC, D, D* and f values) and function analysis are reviewed.Expert commentary: Multiparametric MRI can enable biopsyless diagnosis and more objective staging of diffuse liver disease, cirrhosis and predisposing diseases. A comprehensive approach is needed to understand and overcome the effects of iron, fat, fibrosis, edema, inflammation and copper on MR relaxometry values in diffuse liver disease.
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/17474124.2017.1271710
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2965
Yayın Dili
[dc.language.iso]
eng
Yazar
[dc.contributor.author]
Unal, Emre
Yazar
[dc.contributor.author]
Idilman, Ilkay Sedakat
Yazar
[dc.contributor.author]
Karcaaltincaba, Musturay
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
İlk Sayfa Sayısı
[dc.identifier.startpage]
167
Son Sayfa Sayısı
[dc.identifier.endpage]
182
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
16
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 10:47
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Tıklayınız
enable assessment diffuse mapping imaging patients objective values copper fibrosis diseases function overload stiffness diagnosis disease biopsyless Multiparametric multiparametric implementation acquisition understand overcome staging effects single fingerprinting inflammation determination relaxometry follow-up covered commentary Expert reviewed
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