NECROTISING ENDOCARDITIS OF MITRAL VALVE DUE TO STAPHYLOCOCCUS LUGDUNENSIS

Staphylococcus lugdunensis is an infrequent cause of infective endocarditis (IE) and usually involves native valves of the heart. It causes life-threatening events such as rupture of cardiac valve or cerebral or pulmonary embolism due to necrosis on the endocardial tissue involved by the bacteria. Antibiotic therapy without cardiac surgery or delayed cardiac surgery usually follows a fatal course in S.lugdunensis endocarditis. In this report the first case of S.lugdunensis endocarditis from Turkey was presented. A 37 years-old man was admitted to the emergency department with a 2-weeks history of fever chills and accompanying intermittent pain on the left side of the thorax. Other than recurrent folliculitis continuing for 20 years, his history was unremarkable. Echocardiography revealed vegetation on the mitral valve of the patient and vancomycin plus gentamicin were initiated with the diagnosis of IE. All blood cultures (5 sets) taken on admission and within the initial 48 hours of the antibiotic therapy yielded S.lugdunensis. According to the susceptibility test results, the antibiotic therapy was switched to ampicillin-sulbactam plus rifampin. Blood cultures became negative after the third day of therapy, however, cardiac failure was emerged due to rupture of mitral valve and chorda tendiniea on the 12(th) day of the therapy. Cardiac surgery revealed that mitral valve and surrounding tissue of the valve were evidently necrotic and fragile, anterior leaflet of the mitral valve was covered with vegetation, posterior leaflet and chorda tendiniea were ruptured. Vegetation was removed and the destructed mitral valve was replaced with a mechanical valve. Vegetation culture remained sterile, however, antibiotics were switched to vancomycin plus rifampin due to persistent fever on the 21(st) day of the therapy (9(th) day of operation). Fever resolved four days after the antibiotic switch. Antibiotics were stopped on the 9(th) weeks of admission and the patient was discharged. He had no problem in follow-up controls for one year. In conclusion, proper antibiotic therapy combined with early cardiac surgery seems to be the optimal therapeutic approach in IE caused by S.lugdunensis.

Yazar Celebi, Gueven
Buyukates, Mustafa
Dogan, Sait Mesut
Piskin, Nihal
Aydemir, Hande
Oztoprak, Nefise
Aktas, Elif
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2982
Konu Başlıkları Staphylococcus lugdunensis
infective endocarditis
mitral valve
cardiac surgery
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MIKROBIYOLOJI BULTENI
Dergi Cilt Bilgisi 43
Dergi Sayısı 2
Sayfalar 319 - 323
Yayın Yılı 2009
Eser Adı
[dc.title]
NECROTISING ENDOCARDITIS OF MITRAL VALVE DUE TO STAPHYLOCOCCUS LUGDUNENSIS
Yazar
[dc.contributor.author]
Celebi, Gueven
Yazar
[dc.contributor.author]
Buyukates, Mustafa
Yazar
[dc.contributor.author]
Dogan, Sait Mesut
Yazar
[dc.contributor.author]
Piskin, Nihal
Yazar
[dc.contributor.author]
Aydemir, Hande
Yazar
[dc.contributor.author]
Oztoprak, Nefise
Yazar
[dc.contributor.author]
Aktas, Elif
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
ANKARA MICROBIOLOGY SOC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Staphylococcus lugdunensis is an infrequent cause of infective endocarditis (IE) and usually involves native valves of the heart. It causes life-threatening events such as rupture of cardiac valve or cerebral or pulmonary embolism due to necrosis on the endocardial tissue involved by the bacteria. Antibiotic therapy without cardiac surgery or delayed cardiac surgery usually follows a fatal course in S.lugdunensis endocarditis. In this report the first case of S.lugdunensis endocarditis from Turkey was presented. A 37 years-old man was admitted to the emergency department with a 2-weeks history of fever chills and accompanying intermittent pain on the left side of the thorax. Other than recurrent folliculitis continuing for 20 years, his history was unremarkable. Echocardiography revealed vegetation on the mitral valve of the patient and vancomycin plus gentamicin were initiated with the diagnosis of IE. All blood cultures (5 sets) taken on admission and within the initial 48 hours of the antibiotic therapy yielded S.lugdunensis. According to the susceptibility test results, the antibiotic therapy was switched to ampicillin-sulbactam plus rifampin. Blood cultures became negative after the third day of therapy, however, cardiac failure was emerged due to rupture of mitral valve and chorda tendiniea on the 12(th) day of the therapy. Cardiac surgery revealed that mitral valve and surrounding tissue of the valve were evidently necrotic and fragile, anterior leaflet of the mitral valve was covered with vegetation, posterior leaflet and chorda tendiniea were ruptured. Vegetation was removed and the destructed mitral valve was replaced with a mechanical valve. Vegetation culture remained sterile, however, antibiotics were switched to vancomycin plus rifampin due to persistent fever on the 21(st) day of the therapy (9(th) day of operation). Fever resolved four days after the antibiotic switch. Antibiotics were stopped on the 9(th) weeks of admission and the patient was discharged. He had no problem in follow-up controls for one year. In conclusion, proper antibiotic therapy combined with early cardiac surgery seems to be the optimal therapeutic approach in IE caused by S.lugdunensis.
Açıklama
[dc.description]
WOS: 000265949300019
Açıklama
[dc.description]
PubMed: 19621620
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
Staphylococcus lugdunensis
Konu Başlıkları
[dc.subject]
infective endocarditis
Konu Başlıkları
[dc.subject]
mitral valve
Konu Başlıkları
[dc.subject]
cardiac surgery
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0374-9096
İlk Sayfa Sayısı
[dc.identifier.startpage]
319
Son Sayfa Sayısı
[dc.identifier.endpage]
323
Dergi Adı
[dc.relation.journal]
MIKROBIYOLOJI BULTENI
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
43
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2982
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
42
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 09:29
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Tıklayınız
therapy mitral lugdunensis cardiac antibiotic surgery endocarditis however Vegetation chorda leaflet tendiniea history patient revealed tissue admission switched cultures rifampin usually vegetation vancomycin rupture evidently According susceptibility anterior fragile necrotic results negative surrounding became Cardiac
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