Efficiency of inferior petrosal sinus sampling in the diagnosis of Cushing's disease and comparison with magnetic resonance imaging

OBJECTIVE: The purpose of this study is to assess the efficiency of inferior petrosal sinus sampling (IPSS) in the diagnosis of adrenocorticotropic hormone-dependent Cushing's disease and to compare it with magnetic resonance imaging (MRI). METHODS: The diagnostic efficiency of IPSS in the differentiation of pituitary Cushing's disease from ectopic Cushing's disease was retrospectively evaluated in 37 patients who had IPSS in our clinic. Six patients were excluded from the study due to missing data. Hypophysis MRI examinations of 31 patients before IPSS were also evaluated. The contributions of MRI and IPSS to the detection of pituitary adenoma and the determination of lateralization were researched. RESULTS: Bilateral IPSS was successfully performed in 30 patients of the 31 patients in the study group. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of IPSS in differentiating between central and ectopic Cushing's syndrome before corticotrophin-releasing hormone (CRH) stimulation were 93.3%, 100%, 100%, 33.3%, and 93%, respectively, whereas after CRH stimulation were 100%, 100%, 100%, 100%, and 100%, respectively. The accuracy of both the rates was significantly higher compared with MRI. CONCLUSION: IPSS has the highest diagnostic efficiency in differentiating central Cushing's disease from ectopic Cushing's disease.

Yazar Bekci, Tumay
Belet, Umit
Soylu, Aysegul Idil
Uzunkaya, Fatih
Ozturk, Mesut
Atmaca, Aysegul
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2522
Tek Biçim Adres 10.14744/nci.2018.83584
Konu Başlıkları Angiography
Cushing syndrome
inferior petrosal sinus sampling
magnetic resonance imaging
pituitary
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı NORTHERN CLINICS OF ISTANBUL
Dergi Cilt Bilgisi 6
Dergi Sayısı 1
Sayfalar 53 - 58
Yayın Yılı 2019
Eser Adı
[dc.title]
Efficiency of inferior petrosal sinus sampling in the diagnosis of Cushing's disease and comparison with magnetic resonance imaging
Yazar
[dc.contributor.author]
Bekci, Tumay
Yazar
[dc.contributor.author]
Belet, Umit
Yazar
[dc.contributor.author]
Soylu, Aysegul Idil
Yazar
[dc.contributor.author]
Uzunkaya, Fatih
Yazar
[dc.contributor.author]
Ozturk, Mesut
Yazar
[dc.contributor.author]
Atmaca, Aysegul
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
KARE PUBL
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
OBJECTIVE: The purpose of this study is to assess the efficiency of inferior petrosal sinus sampling (IPSS) in the diagnosis of adrenocorticotropic hormone-dependent Cushing's disease and to compare it with magnetic resonance imaging (MRI). METHODS: The diagnostic efficiency of IPSS in the differentiation of pituitary Cushing's disease from ectopic Cushing's disease was retrospectively evaluated in 37 patients who had IPSS in our clinic. Six patients were excluded from the study due to missing data. Hypophysis MRI examinations of 31 patients before IPSS were also evaluated. The contributions of MRI and IPSS to the detection of pituitary adenoma and the determination of lateralization were researched. RESULTS: Bilateral IPSS was successfully performed in 30 patients of the 31 patients in the study group. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of IPSS in differentiating between central and ectopic Cushing's syndrome before corticotrophin-releasing hormone (CRH) stimulation were 93.3%, 100%, 100%, 33.3%, and 93%, respectively, whereas after CRH stimulation were 100%, 100%, 100%, 100%, and 100%, respectively. The accuracy of both the rates was significantly higher compared with MRI. CONCLUSION: IPSS has the highest diagnostic efficiency in differentiating central Cushing's disease from ectopic Cushing's disease.
Açıklama
[dc.description]
WOS: 000460612600009
Açıklama
[dc.description]
PubMed: 31180374
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Angiography
Konu Başlıkları
[dc.subject]
Cushing syndrome
Konu Başlıkları
[dc.subject]
inferior petrosal sinus sampling
Konu Başlıkları
[dc.subject]
magnetic resonance imaging
Konu Başlıkları
[dc.subject]
pituitary
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2148-4902
İlk Sayfa Sayısı
[dc.identifier.startpage]
53
Son Sayfa Sayısı
[dc.identifier.endpage]
58
Dergi Adı
[dc.relation.journal]
NORTHERN CLINICS OF ISTANBUL
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
6
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.14744/nci.2018.83584
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2522
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
237
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
16 Temmuz 2024 14:57
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Tıklayınız
Cushing disease patients ectopic efficiency differentiating diagnostic pituitary stimulation predictive accuracy central evaluated respectively before between performed negative successfully positive specificity sensitivity OBJECTIVE syndrome highest CONCLUSION compared higher significantly corticotrophin-releasing whereas RESULTS hormone Bilateral missing
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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