The effect of intra-articular levobupivacaine on shoulder cartilage at different doses-experimental study

Background and objectives: In this study it was aimed to examine the histological and morphometric effects on cartilage structure of intra-articular application of levobupivacaine to the shoulder joint. Methods: In twenty New Zealand adult male rabbits, 35 shoulders were used for the study and prepared in 5 groups of 7. These groups were defined as Groups L1, L2, L3 and L4 which were right shoulders administered with 0.25% and 0.5% levobupivacaine, Group C which were left shoulders as the control group and Groups S1 and S2 which were left shoulders administered with 0.9% saline. On the 2nd and 15th days the animals were killed, the glenohumeral joints were evaluated macroscopically then cartilage samples were taken. These samples were evaluated with Mankin score, and histomorphometrically by measuring the thickness of the cartilage between the superficial cartilage layer and the tidemark and the thickness of calcified cartilage between the tidemark and the subchondral bone. Results: Macroscopically, on the 15th day the joint fluid was seen to have reduced in all the groups. After microscopic evaluation, the highest Mankin score (mean: 3.14 +/- 2.1/14) was in the L4 group (15th day 0.5% levobupivacaine) and was found to be statistically significant (p < 0.05). No statistically significant difference was determined between the other groups. Conclusions: Histologically, as the highest Mankin score was in the L4 group, this indicates that in a single intra-articular injection of levobupivacaine a low concentration should be selected. Level of evidence: Level 5, animal study. (C) 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.

Yazar Ozcan, Mustafa Soner
Kalem, Mahmut
Ozcelik, Menekse
Sahin, Ercan
Cakar, Sanem
Hayirli, Nazli
Evirgen, Oya
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3509
Tek Biçim Adres 10.1016/j.bjane.2015.08.008
Konu Başlıkları Glenohumeral joint
Chondrolysis
Levobupivacaine
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Cilt Bilgisi 67
Dergi Sayısı 1
Sayfalar 42 - 49
Yayın Yılı 2017
Eser Adı
[dc.title]
The effect of intra-articular levobupivacaine on shoulder cartilage at different doses-experimental study
Yazar
[dc.contributor.author]
Ozcan, Mustafa Soner
Yazar
[dc.contributor.author]
Kalem, Mahmut
Yazar
[dc.contributor.author]
Ozcelik, Menekse
Yazar
[dc.contributor.author]
Sahin, Ercan
Yazar
[dc.contributor.author]
Cakar, Sanem
Yazar
[dc.contributor.author]
Hayirli, Nazli
Yazar
[dc.contributor.author]
Evirgen, Oya
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
ELSEVIER SCIENCE INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background and objectives: In this study it was aimed to examine the histological and morphometric effects on cartilage structure of intra-articular application of levobupivacaine to the shoulder joint. Methods: In twenty New Zealand adult male rabbits, 35 shoulders were used for the study and prepared in 5 groups of 7. These groups were defined as Groups L1, L2, L3 and L4 which were right shoulders administered with 0.25% and 0.5% levobupivacaine, Group C which were left shoulders as the control group and Groups S1 and S2 which were left shoulders administered with 0.9% saline. On the 2nd and 15th days the animals were killed, the glenohumeral joints were evaluated macroscopically then cartilage samples were taken. These samples were evaluated with Mankin score, and histomorphometrically by measuring the thickness of the cartilage between the superficial cartilage layer and the tidemark and the thickness of calcified cartilage between the tidemark and the subchondral bone. Results: Macroscopically, on the 15th day the joint fluid was seen to have reduced in all the groups. After microscopic evaluation, the highest Mankin score (mean: 3.14 +/- 2.1/14) was in the L4 group (15th day 0.5% levobupivacaine) and was found to be statistically significant (p < 0.05). No statistically significant difference was determined between the other groups. Conclusions: Histologically, as the highest Mankin score was in the L4 group, this indicates that in a single intra-articular injection of levobupivacaine a low concentration should be selected. Level of evidence: Level 5, animal study. (C) 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda.
Açıklama
[dc.description]
WOS: 000394033300007
Açıklama
[dc.description]
PubMed: 28017169
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Glenohumeral joint
Konu Başlıkları
[dc.subject]
Chondrolysis
Konu Başlıkları
[dc.subject]
Levobupivacaine
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0034-7094
ISSN
[dc.identifier.issn]
1806-907X
İlk Sayfa Sayısı
[dc.identifier.startpage]
42
Son Sayfa Sayısı
[dc.identifier.endpage]
49
Dergi Adı
[dc.relation.journal]
REVISTA BRASILEIRA DE ANESTESIOLOGIA
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
67
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/j.bjane.2015.08.008
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3509
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Şubat 2024 02:20
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Tıklayınız
cartilage shoulders groups Mankin levobupivacaine between Groups administered statistically evaluated significant tidemark intra-articular samples highest thickness reduced levobupivacaine) microscopic evaluation Conclusions selected Editora Elsevier Published Anestesiologia Brasileira Sociedade animal evidence should concentration injection single indicates
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