Bone mineral density and bone turnover markers of patients with Behcet's disease

Background Behcet's disease (BD) is a systemic inflammatory disease of unknown aetiology. The pathogenesis of rheumatological findings and the status of bone metabolism in this disease are unknown. Inflammatory diseases may predispose to a decrease in bone mineral density (BMD) and there are many studies concerning osteoporosis in chronic inflammatory diseases. Objective The aim of this study was to investigate BMD and bone turnover markers in patients with BD. Methods Thirty BD patients (17 male and 13 female patients, mean age 36.9 +/- 12.6 years) and a total of 30 age- and sex-matched healthy controls (17 male and 13 female controls, mean age 34.9 +/- 8.95 years) recruited from the general population were enrolled in the study. Bone mineral density was measured at the lumbar spine (L1-4) and the left hip (total hip) using dual energy X-ray absorptiometry. Serum samples were collected between 8 and 10 am after overnight fasting. Serum calcium (Ca), phosphate (P), parathormone (PTH), total alkaline phosphatase (ALP), osteocalcin (OC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were measured. Free deoxypyridinoline cross-links (DPD) in second-void urine and total daily urinary calcium excretion were analysed. Results No statistically significant difference in lumbar spine or femoral BMD and bone turnover markers were found between BD patients and control groups (P > 0.05). Conclusion Although it is difficult to draw definite conclusions because of the limited number of patients involved, our study indicates that bone mineral density and bone turnover markers in Behcet's disease were no different than in healthy subjects.

Yazar Tekin, N. S.
Ozdolap, S.
Sarikaya, S.
Esturk, E.
Gumustas, S.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2169
Tek Biçim Adres 10.1111/j.1468-3083.2006.01845.x
Konu Başlıkları Behcet's disease
bone metabolism
bone mineral density
osteoporosis
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Dergi Cilt Bilgisi 21
Dergi Sayısı 1
Sayfalar 25 - 29
Yayın Yılı 2007
Eser Adı
[dc.title]
Bone mineral density and bone turnover markers of patients with Behcet's disease
Yazar
[dc.contributor.author]
Tekin, N. S.
Yazar
[dc.contributor.author]
Ozdolap, S.
Yazar
[dc.contributor.author]
Sarikaya, S.
Yazar
[dc.contributor.author]
Esturk, E.
Yazar
[dc.contributor.author]
Gumustas, S.
Yayın Yılı
[dc.date.issued]
2007
Yayıncı
[dc.publisher]
BLACKWELL PUBLISHING
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background Behcet's disease (BD) is a systemic inflammatory disease of unknown aetiology. The pathogenesis of rheumatological findings and the status of bone metabolism in this disease are unknown. Inflammatory diseases may predispose to a decrease in bone mineral density (BMD) and there are many studies concerning osteoporosis in chronic inflammatory diseases. Objective The aim of this study was to investigate BMD and bone turnover markers in patients with BD. Methods Thirty BD patients (17 male and 13 female patients, mean age 36.9 +/- 12.6 years) and a total of 30 age- and sex-matched healthy controls (17 male and 13 female controls, mean age 34.9 +/- 8.95 years) recruited from the general population were enrolled in the study. Bone mineral density was measured at the lumbar spine (L1-4) and the left hip (total hip) using dual energy X-ray absorptiometry. Serum samples were collected between 8 and 10 am after overnight fasting. Serum calcium (Ca), phosphate (P), parathormone (PTH), total alkaline phosphatase (ALP), osteocalcin (OC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were measured. Free deoxypyridinoline cross-links (DPD) in second-void urine and total daily urinary calcium excretion were analysed. Results No statistically significant difference in lumbar spine or femoral BMD and bone turnover markers were found between BD patients and control groups (P > 0.05). Conclusion Although it is difficult to draw definite conclusions because of the limited number of patients involved, our study indicates that bone mineral density and bone turnover markers in Behcet's disease were no different than in healthy subjects.
Açıklama
[dc.description]
WOS: 000243297700004
Açıklama
[dc.description]
PubMed: 17207163
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Behcet's disease
Konu Başlıkları
[dc.subject]
bone metabolism
Konu Başlıkları
[dc.subject]
bone mineral density
Konu Başlıkları
[dc.subject]
osteoporosis
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0926-9959
İlk Sayfa Sayısı
[dc.identifier.startpage]
25
Son Sayfa Sayısı
[dc.identifier.endpage]
29
Dergi Adı
[dc.relation.journal]
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
21
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/j.1468-3083.2006.01845.x
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2169
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
38
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
16 Temmuz 2024 23:15
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Tıklayınız
patients disease markers turnover mineral density Behcet measured calcium female years) healthy lumbar controls diseases between unknown inflammatory parathormone urinary excretion analysed alkaline osteocalcin phosphatase second-void erythrocyte sedimentation C-reactive cross-links deoxypyridinoline protein Background Results difficult
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