The Effects of Resveratrol on the Healing of Left Colonic Anastomosis

Introduction: Resveratrol (RSV) is a natural polyphenolic compound found in grape skins and the red wine which improves histological reorganization of the regenerating tissue in dermal wound healing. Since anastomotic healing possesses paramount importance to prevent complications in colorectal surgery, the present study is aimed to evaluate the effect of RSV on the healing of experimental left colonic anastomoses. Methods: Thirty-two male Wistar albino rats were randomized into two groups and subjected to colonic anastomosis. The study group was treated with RSV and the control group received tap water instead. The rats were sacrificed 3 and 7 days postoperatively. Wound complications, intra-abdominal abscesses, and anastomotic leaks and stenosis were recorded. Four types of assessment were performed: bursting pressure, hydroxyproline (OHP) content, histopathology, and biochemical analysis. Results: Compared to the control group, the RSV-treated rats displayed a higher bursting pressure (p < .001) and anastomotic OHP content (p < .05)]. RSV treatment leads to significant increase in PON activity at both time points and decrease in malondialdehyde levels on postoperative day 3 (p < .001). Histopathological analysis revealed that RSV administration leads to a better anastomotic healing in terms of mucosal ischemia, neovascularization, reepithelialization, fibroblast, and lymphocyte infiltration. Conclusion: The study results suggest that exogenous RSV administration exerts a positive effect on experimental colonic wound healing in the rat. Although the precise cellular mechanisms by which RSV enhances anastomotic wound healing is not clear, stimulation of neovascularization, generation of collagen synthesis, inhibition of overinflammation, and restriction of oxidative injury seems to be of paramount importance.

Yazar Cakmak, G. Karadeniz
Irkorucu, O.
Ucan, B. H.
Tascilar, O.
Emre, A. U.
Karakaya, K.
Bahadir, B.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3569
Tek Biçim Adres 10.1080/08941930903214701
Konu Başlıkları resveratrol
anastomosis
wound healing
complication
oxidative stress
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF INVESTIGATIVE SURGERY
Dergi Cilt Bilgisi 22
Dergi Sayısı 5
Sayfalar 353 - 361
Yayın Yılı 2009
Eser Adı
[dc.title]
The Effects of Resveratrol on the Healing of Left Colonic Anastomosis
Yazar
[dc.contributor.author]
Cakmak, G. Karadeniz
Yazar
[dc.contributor.author]
Irkorucu, O.
Yazar
[dc.contributor.author]
Ucan, B. H.
Yazar
[dc.contributor.author]
Tascilar, O.
Yazar
[dc.contributor.author]
Emre, A. U.
Yazar
[dc.contributor.author]
Karakaya, K.
Yazar
[dc.contributor.author]
Bahadir, B.
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
TAYLOR & FRANCIS INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: Resveratrol (RSV) is a natural polyphenolic compound found in grape skins and the red wine which improves histological reorganization of the regenerating tissue in dermal wound healing. Since anastomotic healing possesses paramount importance to prevent complications in colorectal surgery, the present study is aimed to evaluate the effect of RSV on the healing of experimental left colonic anastomoses. Methods: Thirty-two male Wistar albino rats were randomized into two groups and subjected to colonic anastomosis. The study group was treated with RSV and the control group received tap water instead. The rats were sacrificed 3 and 7 days postoperatively. Wound complications, intra-abdominal abscesses, and anastomotic leaks and stenosis were recorded. Four types of assessment were performed: bursting pressure, hydroxyproline (OHP) content, histopathology, and biochemical analysis. Results: Compared to the control group, the RSV-treated rats displayed a higher bursting pressure (p < .001) and anastomotic OHP content (p < .05)]. RSV treatment leads to significant increase in PON activity at both time points and decrease in malondialdehyde levels on postoperative day 3 (p < .001). Histopathological analysis revealed that RSV administration leads to a better anastomotic healing in terms of mucosal ischemia, neovascularization, reepithelialization, fibroblast, and lymphocyte infiltration. Conclusion: The study results suggest that exogenous RSV administration exerts a positive effect on experimental colonic wound healing in the rat. Although the precise cellular mechanisms by which RSV enhances anastomotic wound healing is not clear, stimulation of neovascularization, generation of collagen synthesis, inhibition of overinflammation, and restriction of oxidative injury seems to be of paramount importance.
Açıklama
[dc.description]
WOS: 000271092000006
Açıklama
[dc.description]
PubMed: 19842890
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
resveratrol
Konu Başlıkları
[dc.subject]
anastomosis
Konu Başlıkları
[dc.subject]
wound healing
Konu Başlıkları
[dc.subject]
complication
Konu Başlıkları
[dc.subject]
oxidative stress
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0894-1939
İlk Sayfa Sayısı
[dc.identifier.startpage]
353
Son Sayfa Sayısı
[dc.identifier.endpage]
361
Dergi Adı
[dc.relation.journal]
JOURNAL OF INVESTIGATIVE SURGERY
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
22
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1080/08941930903214701
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3569
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
12 Nisan 2024 18:14
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Tıklayınız
healing anastomotic colonic complications effect experimental importance control neovascularization analysis paramount content pressure bursting administration displayed higher revealed Histopathological postoperative levels treatment malondialdehyde decrease significant points increase activity Introduction better synthesis enhances stimulation generation collagen
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