Potential role of dietary omega-3 essential fatty acids on some oxidant/antioxidant parameters in rats' corpus striatum

Omega-3 (omega-3) is an essential fatty acid (EFA) found in large amounts in fish oil. It contains eicosapentaenoic acid and docosahexaenoic acid (DHA). DHA is one of the building structures of membrane phospholipids of brain and necessary for continuity of neuronal functions. Evidences support the hypothesis that schizophrenia may be the result of increased reactive oxygen species mediated neuronal injury. Recent reports also suggest the protective effect of omega-3 EFA against neuropsychiatric disorders including schizophrenia. This study proposed to assess the changes in antioxidant enzyme and oxidant parameters in the corpus striatum (CS) of rats fed with omega-3 EFA diet (0.4 g/kg/day) for 30 days. Eight control rats and nine rats fed with omega-3 were decapitated under ether anesthesia, and CS was removed immediately. Thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) levels as well as total superoxide dismutase (t-SOD) and xanthine oxidase (XO) enzyme activities in the CS were measured. Rats treated with omega-3 EFA had significantly lower values of TBARS (P < 0.001), NO (P < 0.002) and XO (P < 0.005) whereas higher values of t-SOD enzyme activity (P < 0.002) than the control rats. These results indicate that omega-3 EFA rich fish oil diet reduces some oxidant parameters in CS. This may be revealed by means of reduced CS TBARS levels as an end product of lipid peroxidation of membranes in treated rats. Additionally, reduced XO activity and NO levels may support this notion. On the other hand, although the mechanism is not clear, omega-3 EFA may indirectly enhance the activity of antioxidant enzyme t-SOD. Taken together, this preliminary animal study provides strong support for a therapeutic effect of omega-3 EFA supplemented to classical neuroleptic regimen in the treatment of schizophrenic symptoms and tardive dyskinesia. (C) 2003 Elsevier Ltd. All rights reserved.

Yazar Sarsilmaz, M
Songur, A
Ozyurt, H
Kus, I
Ozen, OA
Ozyurt, B
Sogut, S
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3120
Tek Biçim Adres 10.1016/S0952-3278(03)00107-8
Konu Başlıkları omega-3 essential fatty acids
corpus striatum
lipid peroxidation
xanthine oxidase
superoxide dismutase
nitric oxide
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Dergi Cilt Bilgisi 69
Dergi Sayısı 4
Sayfalar 253 - 259
Yayın Yılı 2003
Eser Adı
[dc.title]
Potential role of dietary omega-3 essential fatty acids on some oxidant/antioxidant parameters in rats' corpus striatum
Yazar
[dc.contributor.author]
Sarsilmaz, M
Yazar
[dc.contributor.author]
Songur, A
Yazar
[dc.contributor.author]
Ozyurt, H
Yazar
[dc.contributor.author]
Kus, I
Yazar
[dc.contributor.author]
Ozen, OA
Yazar
[dc.contributor.author]
Ozyurt, B
Yazar
[dc.contributor.author]
Sogut, S
Yayın Yılı
[dc.date.issued]
2003
Yayıncı
[dc.publisher]
ELSEVIER SCI LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Omega-3 (omega-3) is an essential fatty acid (EFA) found in large amounts in fish oil. It contains eicosapentaenoic acid and docosahexaenoic acid (DHA). DHA is one of the building structures of membrane phospholipids of brain and necessary for continuity of neuronal functions. Evidences support the hypothesis that schizophrenia may be the result of increased reactive oxygen species mediated neuronal injury. Recent reports also suggest the protective effect of omega-3 EFA against neuropsychiatric disorders including schizophrenia. This study proposed to assess the changes in antioxidant enzyme and oxidant parameters in the corpus striatum (CS) of rats fed with omega-3 EFA diet (0.4 g/kg/day) for 30 days. Eight control rats and nine rats fed with omega-3 were decapitated under ether anesthesia, and CS was removed immediately. Thiobarbituric acid-reactive substances (TBARS) and nitric oxide (NO) levels as well as total superoxide dismutase (t-SOD) and xanthine oxidase (XO) enzyme activities in the CS were measured. Rats treated with omega-3 EFA had significantly lower values of TBARS (P < 0.001), NO (P < 0.002) and XO (P < 0.005) whereas higher values of t-SOD enzyme activity (P < 0.002) than the control rats. These results indicate that omega-3 EFA rich fish oil diet reduces some oxidant parameters in CS. This may be revealed by means of reduced CS TBARS levels as an end product of lipid peroxidation of membranes in treated rats. Additionally, reduced XO activity and NO levels may support this notion. On the other hand, although the mechanism is not clear, omega-3 EFA may indirectly enhance the activity of antioxidant enzyme t-SOD. Taken together, this preliminary animal study provides strong support for a therapeutic effect of omega-3 EFA supplemented to classical neuroleptic regimen in the treatment of schizophrenic symptoms and tardive dyskinesia. (C) 2003 Elsevier Ltd. All rights reserved.
Açıklama
[dc.description]
WOS: 000185414500007
Açıklama
[dc.description]
PubMed: 12907135
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
omega-3 essential fatty acids
Konu Başlıkları
[dc.subject]
corpus striatum
Konu Başlıkları
[dc.subject]
lipid peroxidation
Konu Başlıkları
[dc.subject]
xanthine oxidase
Konu Başlıkları
[dc.subject]
superoxide dismutase
Konu Başlıkları
[dc.subject]
nitric oxide
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0952-3278
ISSN
[dc.identifier.issn]
1532-2823
İlk Sayfa Sayısı
[dc.identifier.startpage]
253
Son Sayfa Sayısı
[dc.identifier.endpage]
259
Dergi Adı
[dc.relation.journal]
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
69
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/S0952-3278(03)00107-8
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3120
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
9
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
05 Şubat 2024 19:50
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Tıklayınız
omega-3 enzyme support levels activity effect parameters oxidant schizophrenia control neuronal treated values antioxidant reduced reduces higher whereas significantly revealed results indicate Omega-3 symptoms therapeutic supplemented classical neuroleptic regimen treatment schizophrenic tardive strong dyskinesia Elsevier
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