The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia

Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF-alpha and IL-6 in CAE patients. Methods. Plasma concentrations of TNF-alpha and IL-6 were measured in 36 patients with CAE (28 males, mean age: 58.2 +/- 12 years), and results were compared with age and sex-matched controls (n = 32) without coronary artery ectasia. TNF-alpha and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA). Results. Baseline characteristics of the two groups were similar. TNF-alpha and IL-6 levels were significantly higher in CAE group than controls (15.6 +/- 11.2 pg/mL versus 7.8 +/- 3.7 pg/mL, P<.001, and 17.2 +/- 12.6 versus 7.6 +/- 2.1, P<.0001, resp.). Conclusion. CAE patients showed increases in TNF-alpha and IL-6 levels compared to the controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE. Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-alpha and IL-6 levels. Copyright (C) 2009 Mustafa Aydin et al.

Yazar Aydin, Mustafa
Tekin, Ishak Ozel
Dogan, Sait Mesut
Yildirim, Nesligul
Arasli, Mehmet
Sayin, Muhammet Rasit
Aktop, Ziyaettin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3623
Tek Biçim Adres 10.1155/2009/106145
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MEDIATORS OF INFLAMMATION
Sayfalar -
Yayın Yılı 2009
Eser Adı
[dc.title]
The Levels of Tumor Necrosis Factor-Alpha and Interleukin-6 in Patients with Isolated Coronary Artery Ectasia
Yazar
[dc.contributor.author]
Aydin, Mustafa
Yazar
[dc.contributor.author]
Tekin, Ishak Ozel
Yazar
[dc.contributor.author]
Dogan, Sait Mesut
Yazar
[dc.contributor.author]
Yildirim, Nesligul
Yazar
[dc.contributor.author]
Arasli, Mehmet
Yazar
[dc.contributor.author]
Sayin, Muhammet Rasit
Yazar
[dc.contributor.author]
Aktop, Ziyaettin
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
HINDAWI PUBLISHING CORPORATION
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/Aim. Coronary artery ectasia (CAE) is considered as a variant of atherosclerosis. Tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) are among the sensitive markers of systemic inflammation. The aim of this study was to evaluate the plasma levels of the cytokines; TNF-alpha and IL-6 in CAE patients. Methods. Plasma concentrations of TNF-alpha and IL-6 were measured in 36 patients with CAE (28 males, mean age: 58.2 +/- 12 years), and results were compared with age and sex-matched controls (n = 32) without coronary artery ectasia. TNF-alpha and IL-6 concentrations in blood were assesed by enzyme-linked immunosorbent assay (ELISA). Results. Baseline characteristics of the two groups were similar. TNF-alpha and IL-6 levels were significantly higher in CAE group than controls (15.6 +/- 11.2 pg/mL versus 7.8 +/- 3.7 pg/mL, P<.001, and 17.2 +/- 12.6 versus 7.6 +/- 2.1, P<.0001, resp.). Conclusion. CAE patients showed increases in TNF-alpha and IL-6 levels compared to the controls. This study provides evidence for alterations in the proinflamatory cytokines which suggest the involvement of the immune system in the pathophysiology of CAE. Further placebo-controlled studies are needed to evaluate the clinical significance of this increase in TNF-alpha and IL-6 levels. Copyright (C) 2009 Mustafa Aydin et al.
Açıklama
[dc.description]
WOS: 000267560300001
Açıklama
[dc.description]
PubMed: 19551157
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0962-9351
Dergi Adı
[dc.relation.journal]
MEDIATORS OF INFLAMMATION
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2009/106145
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3623
Görüntülenme Sayısı ( Şehir )
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122
09.12.2022 tarihinden bu yana
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1
09.12.2022 tarihinden bu yana
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TNF-alpha levels patients controls evaluate compared cytokines artery ectasia concentrations versus Conclusion higher showed Background/Aim increases placebo-controlled Mustafa Copyright increase significance clinical needed studies Further pathophysiology system immune involvement suggest proinflamatory alterations similar evidence provides
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