The importance of myeloperoxidase enzyme activity in the pathogenesis of Crimean-Congo haemorrhagic fever

Crimean-Congo haemorrhagic fever (CCHF) is a disease with a severe course including acute viral haemorrhagic fever, ecchymosis, thrombocytopenia, hepatic function disorder and high mortality. Myeloperoxidase (MPO) is an enzyme located in neutrophil granulocytes and plays an important role in the destruction of phagocytosed micro-organisms. The aim of this study was to analyse MPO enzyme activity in CCHF cases compared with a control group. A total of 47 randomly selected CCHF patients admitted to the Department of Infectious Diseases of Cumhuriyet University Hospital in Sivas, Turkey, were studied, and as a control group, 41 age- and sex-matched individuals without any systemic disease were included in this study. MPO enzyme activity was measured in plasma and leukocytes for both groups by the ELISA method. MPO plasma and MPO leukocyte values were calculated as 57.62 +/- 8.85 and 44.84 +/- 9.71 in CCHF patients, and 0.79 +/- 0.29 and 0.49 +/- 0.11 in the controls, respectively. MPO enzyme activity was statistically significantly higher in patients with CCHF when compared to the control group. In conclusion, MPO enzyme activity is directly related to the activation of phagocytic leukocytes, and increases in both the plasma and leukocytes in CCHF patients. The increase of the MPO enzyme activity in leukocytes due to viral load leads to the destruction of the leukocyte. It is thought that MPO enzyme activity in plasma was higher in CCHF patients due to the destruction of leukocytes. MPO enzyme activity may be important in terms of the prognosis in patients with CCHF; however, more extensive studies are required on this subject.

Yazar Guven, F. M. K.
Aydin, H.
Yildiz, G.
Engin, A.
Celik, V. K.
Bakir, D.
Deveci, K.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3612
Tek Biçim Adres 10.1099/jmm.0.047589-0
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF MEDICAL MICROBIOLOGY
Dergi Cilt Bilgisi 62
Sayfalar 441 - 445
Yayın Yılı 2013
Eser Adı
[dc.title]
The importance of myeloperoxidase enzyme activity in the pathogenesis of Crimean-Congo haemorrhagic fever
Yazar
[dc.contributor.author]
Guven, F. M. K.
Yazar
[dc.contributor.author]
Aydin, H.
Yazar
[dc.contributor.author]
Yildiz, G.
Yazar
[dc.contributor.author]
Engin, A.
Yazar
[dc.contributor.author]
Celik, V. K.
Yazar
[dc.contributor.author]
Bakir, D.
Yazar
[dc.contributor.author]
Deveci, K.
Yayın Yılı
[dc.date.issued]
2013
Yayıncı
[dc.publisher]
MICROBIOLOGY SOC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Crimean-Congo haemorrhagic fever (CCHF) is a disease with a severe course including acute viral haemorrhagic fever, ecchymosis, thrombocytopenia, hepatic function disorder and high mortality. Myeloperoxidase (MPO) is an enzyme located in neutrophil granulocytes and plays an important role in the destruction of phagocytosed micro-organisms. The aim of this study was to analyse MPO enzyme activity in CCHF cases compared with a control group. A total of 47 randomly selected CCHF patients admitted to the Department of Infectious Diseases of Cumhuriyet University Hospital in Sivas, Turkey, were studied, and as a control group, 41 age- and sex-matched individuals without any systemic disease were included in this study. MPO enzyme activity was measured in plasma and leukocytes for both groups by the ELISA method. MPO plasma and MPO leukocyte values were calculated as 57.62 +/- 8.85 and 44.84 +/- 9.71 in CCHF patients, and 0.79 +/- 0.29 and 0.49 +/- 0.11 in the controls, respectively. MPO enzyme activity was statistically significantly higher in patients with CCHF when compared to the control group. In conclusion, MPO enzyme activity is directly related to the activation of phagocytic leukocytes, and increases in both the plasma and leukocytes in CCHF patients. The increase of the MPO enzyme activity in leukocytes due to viral load leads to the destruction of the leukocyte. It is thought that MPO enzyme activity in plasma was higher in CCHF patients due to the destruction of leukocytes. MPO enzyme activity may be important in terms of the prognosis in patients with CCHF; however, more extensive studies are required on this subject.
Açıklama
[dc.description]
WOS: 000316514600013
Açıklama
[dc.description]
PubMed: 23139398
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0022-2615
ISSN
[dc.identifier.issn]
1473-5644
İlk Sayfa Sayısı
[dc.identifier.startpage]
441
Son Sayfa Sayısı
[dc.identifier.endpage]
445
Dergi Adı
[dc.relation.journal]
JOURNAL OF MEDICAL MICROBIOLOGY
Dergi Cilt Bilgisi
[dc.identifier.volume]
62
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1099/jmm.0.047589-0
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3612
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
5
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
10 Kasım 2023 09:24
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Tıklayınız
enzyme activity patients leukocytes plasma destruction control compared haemorrhagic higher leukocyte important disease studies required increase controls calculated subject values statistically respectively increases phagocytic activation method thought related extensive directly prognosis however conclusion significantly Crimean-Congo
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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