Comparison of thiopental and ketamine plus xylazine anesthesia in ischemia/reperfusion-induced arrhythmias in rats

Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0 +/- 2.1 versus 3.7 +/- 1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods. Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model.

Dergi Adı TURKISH JOURNAL OF MEDICAL SCIENCES
Dergi Cilt Bilgisi 45
Dergi Sayısı 6
Sayfalar 1413 - 1420
Yayın Yılı 2015
Eser Adı
[dc.title]
Comparison of thiopental and ketamine plus xylazine anesthesia in ischemia/reperfusion-induced arrhythmias in rats
Yazar
[dc.contributor.author]
Gonca, Ersoz
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
TUBITAK SCIENTIFIC & TECHNICAL RESEARCH COUNCIL TURKEY
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background/aim: To investigate the influence of thiopental (85 mg/kg, intraperitoneally (ip)), and ketamine+xylazine (ketamine 75 mg/kg and xylazine 8 mg/kg, ip) anesthesia on the incidence and duration of ischemia/reperfusion-induced arrhythmias. Materials and methods: Myocardial ischemia was induced by a 6-min ligation of the left anterior descending coronary artery, followed by a 6-min reperfusion. Measurements were taken of the incidence and duration of ventricular arrhythmias, the mean arterial blood pressure and heart rate, and the pressure rate-product (as an index of myocardial oxygen consumption). Results: The arrhythmia score and the incidence of ventricular fibrillation and tachycardia were significantly decreased in the ketamine+xylazine-anesthetized rats compared with the thiopental-anesthetized group (arrhythmia score: 2.0 +/- 2.1 versus 3.7 +/- 1.2, P < 0.05). The heart rate was significantly lower in the ketamine+xylazine group during the entire experiment, whilst the pressure-rate product was also significantly lower in the ketamine+xylazine group at different time points of the ischemia and reperfusion periods. Conclusion: Ketamine+xylazine anesthesia has a strong antiarrhythmic effect and an apparent depressive action on the heart rate and the myocardial oxygen consumption index. Therefore, ketamine+xylazine anesthesia is not appropriate for the evaluation of possible antiarrhythmic agents. Thiopental anesthesia is preferable to ketamine+xylazine anesthesia in the in vivo ischemia-reperfusion arrhythmia model.
Açıklama
[dc.description]
WOS: 000365510300034
Açıklama
[dc.description]
PubMed: 26775402
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Anesthetics
Konu Başlıkları
[dc.subject]
ischemia/reperfusion
Konu Başlıkları
[dc.subject]
ventricular arrhythmias
Konu Başlıkları
[dc.subject]
rat
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1300-0144
ISSN
[dc.identifier.issn]
1303-6165
İlk Sayfa Sayısı
[dc.identifier.startpage]
1413
Son Sayfa Sayısı
[dc.identifier.endpage]
1420
Dergi Adı
[dc.relation.journal]
TURKISH JOURNAL OF MEDICAL SCIENCES
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
45
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.3906/sag-1403-25
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2289
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 08:54
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Tıklayınız
ketamine+xylazine anesthesia significantly incidence pressure arrhythmia ventricular reperfusion antiarrhythmic oxygen myocardial ischemia duration arrhythmias during possible agents experiment entire Thiopental preferable whilst ischemia-reperfusion evaluation pressure-rate consumption effect depressive strong Conclusion action periods points Therefore different
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