Potential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study

Background: Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. Material/Methods: This study was conducted on the same day in 5 different hospitals in Turkey. We included patients aged (3) 18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. The Micromedex (R) online drug reference system was used to control and describe the interactions. Drug interactions were classified as contraindicated, major, moderate, and minor. Results: Potential drug-drug interactions with antimicrobials were 26.4% of all interactions. Five (42%) of 12 contraindicated interactions and 61 (38%) of 159 major interactions were with antimicrobials. Quinolones, triazoles, metronidazole, linezolid, and clarithromycin accounted for 173 (25.7%) of 673 prescribed antimicrobials, but were responsible for 141 (92.1%) of 153 interactions. In multivariate analysis, number of prescribed antimicrobials (odds ratio: 2.3001, 95% CI: 1.6237-3.2582), number of prescribed drugs (odds ratio: 1.2008, 95% CI: 1.0943-1.3177), and hospitalization in the university hospital (odds ratio: 1.7798, 95% CI: 1.0035-3.1564) were independent risk factors for developing drug interactions. Conclusions: Due to risk of drug interactions, physicians should be more cautious when prescribing antimicrobials, particularly when prescribing quinolones, linezolid, azoles, metronidazole, and macrolides.

Yazar Kuscu, Ferit
Ulu, Astihan
Inal, Ayse S.
Suntur, Bedia M.
Aydemir, Hande
Gul, Serdar
Ecemis, Kenan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3118
Tek Biçim Adres 10.12659/MSM.908589
Konu Başlıkları Anti-Infective Agents
Drug Interactions
Polypharmacy
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı MEDICAL SCIENCE MONITOR
Dergi Cilt Bilgisi 24
Sayfalar 4240 - 4247
Yayın Yılı 2018
Eser Adı
[dc.title]
Potential Drug-Drug Interactions with Antimicrobials in Hospitalized Patients: A Multicenter Point-Prevalence Study
Yazar
[dc.contributor.author]
Kuscu, Ferit
Yazar
[dc.contributor.author]
Ulu, Astihan
Yazar
[dc.contributor.author]
Inal, Ayse S.
Yazar
[dc.contributor.author]
Suntur, Bedia M.
Yazar
[dc.contributor.author]
Aydemir, Hande
Yazar
[dc.contributor.author]
Gul, Serdar
Yazar
[dc.contributor.author]
Ecemis, Kenan
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
INT SCIENTIFIC INFORMATION, INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: Improper use of antimicrobials can cause adverse drug events and high costs. The purpose of this study was to investigate the frequency and potential drug-drug interactions associated with antimicrobials among hospitalized patients. Material/Methods: This study was conducted on the same day in 5 different hospitals in Turkey. We included patients aged (3) 18 years who received at least 1 antimicrobial drug and at least 1 of any other drug. The Micromedex (R) online drug reference system was used to control and describe the interactions. Drug interactions were classified as contraindicated, major, moderate, and minor. Results: Potential drug-drug interactions with antimicrobials were 26.4% of all interactions. Five (42%) of 12 contraindicated interactions and 61 (38%) of 159 major interactions were with antimicrobials. Quinolones, triazoles, metronidazole, linezolid, and clarithromycin accounted for 173 (25.7%) of 673 prescribed antimicrobials, but were responsible for 141 (92.1%) of 153 interactions. In multivariate analysis, number of prescribed antimicrobials (odds ratio: 2.3001, 95% CI: 1.6237-3.2582), number of prescribed drugs (odds ratio: 1.2008, 95% CI: 1.0943-1.3177), and hospitalization in the university hospital (odds ratio: 1.7798, 95% CI: 1.0035-3.1564) were independent risk factors for developing drug interactions. Conclusions: Due to risk of drug interactions, physicians should be more cautious when prescribing antimicrobials, particularly when prescribing quinolones, linezolid, azoles, metronidazole, and macrolides.
Açıklama
[dc.description]
WOS: 000436365200003
Açıklama
[dc.description]
PubMed: 29924770
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Anti-Infective Agents
Konu Başlıkları
[dc.subject]
Drug Interactions
Konu Başlıkları
[dc.subject]
Polypharmacy
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1643-3750
İlk Sayfa Sayısı
[dc.identifier.startpage]
4240
Son Sayfa Sayısı
[dc.identifier.endpage]
4247
Dergi Adı
[dc.relation.journal]
MEDICAL SCIENCE MONITOR
Dergi Cilt Bilgisi
[dc.identifier.volume]
24
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.12659/MSM.908589
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3118
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
12
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 07:55
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Tıklayınız
interactions antimicrobials prescribed number linezolid patients metronidazole drug-drug contraindicated prescribing triazoles clarithromycin analysis multivariate responsible accounted Background 0943-1 factors macrolides azoles quinolones particularly cautious should physicians Conclusions developing independent 0035-3 hospital university hospitalization 6237-3 Quinolones
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