Hematopoietic Stem Cell Transplantation in a Very High Risk Group of Patients with the Support of Granulocyte Transfusion

High risk patients with active fungal infection who had undergone hematopoietic stem cell transplantation (HSCT) with the support of granulocyte transfusions (GTX) as an adjunct to antifungal agents are reviewed retrospectively. Patients requiring immediate allogeneic HSCT for their primary hematological disorders (two severe aplastic anemia, one T cell acute lymphoblastic leukemia (ALL) in second complete remission, one acute myeloid leukemia (AML)-in first complete remission, one T-ALL in refractory relapse) but were denied by other transplant programs due to active invasive fungal infections had undergone HSCT with the support of GTX at the stem cell transplantation unit of Gazi University. Five patients who had undergone six transplants were included in the study and received a total of 38 (3-13) granulocyte transfusions during these six transplants. The median granulocyte concentration was 3.4 x 10(11) per apheresis bag. Full clinical and radiological recovery was achieved in three of the five high risk patients with active invasive fungal infection with the combination of antifungal agents and GTX. Even a very high risk patient with aplastic anemia who had undergone two consecutive transplants due to secondary graft failure was also cured of his primary disease despite the presence of multiple pulmonary fungus balls. Three of the five patients with very high risk features due to the underlying hematological disease and the associated active fungal infection were rescued with allogeneic HSCT performed with the support of GTX combined with antifungal agents. Despite the limitations of this report due to its retrospective nature, it suggests that GTX might be an alternative in patients with active fungal infections who otherwise are denied by the transplant programs. However, prospective randomized studies are required to draw a solid conclusion regarding the role of GTX in HSCT recipients in desperate situations such as active fungal infections.

Yazar Yenicesu, Idil
Sucak, Gulsan
Dilsiz, Gunter
Aki, Sahika Zeynep
Yegin, Zeynep Arzu
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2711
Tek Biçim Adres 10.1007/s12288-011-0078-y
Konu Başlıkları Stem cell transplantation
Granulocyte transfusion
Fungal infection
Anti-fungal treatment
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
Dergi Cilt Bilgisi 27
Dergi Sayısı 3
Sayfalar 146 - 151
Yayın Yılı 2011
Eser Adı
[dc.title]
Hematopoietic Stem Cell Transplantation in a Very High Risk Group of Patients with the Support of Granulocyte Transfusion
Yazar
[dc.contributor.author]
Yenicesu, Idil
Yazar
[dc.contributor.author]
Sucak, Gulsan
Yazar
[dc.contributor.author]
Dilsiz, Gunter
Yazar
[dc.contributor.author]
Aki, Sahika Zeynep
Yazar
[dc.contributor.author]
Yegin, Zeynep Arzu
Yayın Yılı
[dc.date.issued]
2011
Yayıncı
[dc.publisher]
SPRINGER INDIA
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
High risk patients with active fungal infection who had undergone hematopoietic stem cell transplantation (HSCT) with the support of granulocyte transfusions (GTX) as an adjunct to antifungal agents are reviewed retrospectively. Patients requiring immediate allogeneic HSCT for their primary hematological disorders (two severe aplastic anemia, one T cell acute lymphoblastic leukemia (ALL) in second complete remission, one acute myeloid leukemia (AML)-in first complete remission, one T-ALL in refractory relapse) but were denied by other transplant programs due to active invasive fungal infections had undergone HSCT with the support of GTX at the stem cell transplantation unit of Gazi University. Five patients who had undergone six transplants were included in the study and received a total of 38 (3-13) granulocyte transfusions during these six transplants. The median granulocyte concentration was 3.4 x 10(11) per apheresis bag. Full clinical and radiological recovery was achieved in three of the five high risk patients with active invasive fungal infection with the combination of antifungal agents and GTX. Even a very high risk patient with aplastic anemia who had undergone two consecutive transplants due to secondary graft failure was also cured of his primary disease despite the presence of multiple pulmonary fungus balls. Three of the five patients with very high risk features due to the underlying hematological disease and the associated active fungal infection were rescued with allogeneic HSCT performed with the support of GTX combined with antifungal agents. Despite the limitations of this report due to its retrospective nature, it suggests that GTX might be an alternative in patients with active fungal infections who otherwise are denied by the transplant programs. However, prospective randomized studies are required to draw a solid conclusion regarding the role of GTX in HSCT recipients in desperate situations such as active fungal infections.
Açıklama
[dc.description]
WOS: 000293856200005
Açıklama
[dc.description]
PubMed: 22942564
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Stem cell transplantation
Konu Başlıkları
[dc.subject]
Granulocyte transfusion
Konu Başlıkları
[dc.subject]
Fungal infection
Konu Başlıkları
[dc.subject]
Anti-fungal treatment
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0971-4502
İlk Sayfa Sayısı
[dc.identifier.startpage]
146
Son Sayfa Sayısı
[dc.identifier.endpage]
151
Dergi Adı
[dc.relation.journal]
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
27
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s12288-011-0078-y
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2711
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
70
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
16 Temmuz 2024 15:57
Google Kontrol
Tıklayınız
active fungal patients undergone agents infections transplants antifungal support infection granulocyte transfusions remission denied invasive programs transplantation disease leukemia transplant complete hematological allogeneic primary aplastic anemia pulmonary multiple presence despite features fungus regarding underlying failure
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms