Correlation of vascular endothelial growth factor and vascular endothelial growth factor receptor-1 levels in serum and thyroid nodules with histopathological and radiological variables

BACKGROUND/AIM: Vascular endothelial growth factor (VEGF) is a major cytokine in angiogenesis and has a role on aggressivity of various tumors. The expression of VEGF has been shown to increase in differential thyroid cancer. The aim of the study was to evaluate serum and intranodular VEGF (nVEGF) and VEGF receptor-1 (VEGFR-1) levels in patients with thyroid nodules and their relevance to ultrasonographic and pathological results. MATERIALS AND METHODS: A total of eighty patients were included in the study. Thyroid fine-needle aspiration biopsies were performed, and the levels of serum and nVEGF and VEGFR-1 were measured. Any possible correlations between serum and nVEGF, VEGFR-1, and biochemical/radiological variables were investigated. RESULTS: There were no significant differences between serum VEGF (sVEGF), nVEGF, sVEGFR-1, nVEGFR-1 levels, number of nodules, size of nodules, and benign and malignant ultrasonographic features. sVEGF and nVEGF were higher in malignant or suspicious nodules than that in benign nodules, but did not reach statistical significance (P 0.05). sVEGFR-1 and nVEGFR-1 levels were higher in hyperthyroid patients than that in euthyroid patients (P < 0.05 and P = 0.003, respectively). nVEGFR-1 level was higher in hypothyroid patients than that in euthyroid patients (P = 0.016). sVEGF level was found to be higher in hyperactive nodules than that in others. Both sVEGFR-1 (P = 0.008) and nVEGF levels (P = 0.01) significantly increased with increasing age. nVEGFR-1 decreased with increasing body mass index (BMI) (P = 0.004). CONCLUSIONS: Our study showed the relationships of sVEGF, nVEGF, sVEGFR-1, and nVEGFR-1 levels with age, gender, BMI, and hyperthyroidism. To determine the role of VEGF/VEGFR-1 in thyroid nodules, further studies are required with a large number of patients.

Yazar Haytaoglu, Gurkan
Kuzu, Fatih
Arpaci, Dilek
Altas, Ayfer
Cana, Murat
Barut, Figen
Kokturk, Furuzan
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2317
Tek Biçim Adres 10.4103/JLP.JLP_41_18
Konu Başlıkları Malignancy
nodule
thyroid
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF LABORATORY PHYSICIANS
Dergi Cilt Bilgisi 11
Dergi Sayısı 1
Sayfalar 51 - 57
Yayın Yılı 2019
Eser Adı
[dc.title]
Correlation of vascular endothelial growth factor and vascular endothelial growth factor receptor-1 levels in serum and thyroid nodules with histopathological and radiological variables
Yazar
[dc.contributor.author]
Haytaoglu, Gurkan
Yazar
[dc.contributor.author]
Kuzu, Fatih
Yazar
[dc.contributor.author]
Arpaci, Dilek
Yazar
[dc.contributor.author]
Altas, Ayfer
Yazar
[dc.contributor.author]
Cana, Murat
Yazar
[dc.contributor.author]
Barut, Figen
Yazar
[dc.contributor.author]
Kokturk, Furuzan
Yayın Yılı
[dc.date.issued]
2019
Yayıncı
[dc.publisher]
WOLTERS KLUWER MEDKNOW PUBLICATIONS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
BACKGROUND/AIM: Vascular endothelial growth factor (VEGF) is a major cytokine in angiogenesis and has a role on aggressivity of various tumors. The expression of VEGF has been shown to increase in differential thyroid cancer. The aim of the study was to evaluate serum and intranodular VEGF (nVEGF) and VEGF receptor-1 (VEGFR-1) levels in patients with thyroid nodules and their relevance to ultrasonographic and pathological results. MATERIALS AND METHODS: A total of eighty patients were included in the study. Thyroid fine-needle aspiration biopsies were performed, and the levels of serum and nVEGF and VEGFR-1 were measured. Any possible correlations between serum and nVEGF, VEGFR-1, and biochemical/radiological variables were investigated. RESULTS: There were no significant differences between serum VEGF (sVEGF), nVEGF, sVEGFR-1, nVEGFR-1 levels, number of nodules, size of nodules, and benign and malignant ultrasonographic features. sVEGF and nVEGF were higher in malignant or suspicious nodules than that in benign nodules, but did not reach statistical significance (P 0.05). sVEGFR-1 and nVEGFR-1 levels were higher in hyperthyroid patients than that in euthyroid patients (P < 0.05 and P = 0.003, respectively). nVEGFR-1 level was higher in hypothyroid patients than that in euthyroid patients (P = 0.016). sVEGF level was found to be higher in hyperactive nodules than that in others. Both sVEGFR-1 (P = 0.008) and nVEGF levels (P = 0.01) significantly increased with increasing age. nVEGFR-1 decreased with increasing body mass index (BMI) (P = 0.004). CONCLUSIONS: Our study showed the relationships of sVEGF, nVEGF, sVEGFR-1, and nVEGFR-1 levels with age, gender, BMI, and hyperthyroidism. To determine the role of VEGF/VEGFR-1 in thyroid nodules, further studies are required with a large number of patients.
Açıklama
[dc.description]
WOS: 000461542400010
Açıklama
[dc.description]
PubMed: 30983803
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Malignancy
Konu Başlıkları
[dc.subject]
nodule
Konu Başlıkları
[dc.subject]
thyroid
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0974-2727
ISSN
[dc.identifier.issn]
0974-7826
İlk Sayfa Sayısı
[dc.identifier.startpage]
51
Son Sayfa Sayısı
[dc.identifier.endpage]
57
Dergi Adı
[dc.relation.journal]
JOURNAL OF LABORATORY PHYSICIANS
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
11
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.4103/JLP.JLP_41_18
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2317
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
8
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 06:26
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Tıklayınız
patients nodules levels nVEGFR-1 higher sVEGFR-1 thyroid between malignant benign VEGFR-1 number euthyroid ultrasonographic increasing hyperthyroid VEGF/VEGFR-1 determine significance further statistical studies required suspicious hyperthyroidism CONCLUSIONS showed decreased relationships increased significantly gender others hyperactive hypothyroid
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

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