Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat

Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis. Thirty-two male Wistar albino rats were randomized into two groups and subjected to colonic anastomosis. The study group was treated with simvastatin and the control group received only tap water instead. The rats were killed 3 and 7 days postoperatively. Wound complications, intra-abdominal abscesses, and anastomotic leaks and stenosis were recorded. Four types of assessment were performed: bursting pressure, hydroxyproline content, histopathology, and biochemical analysis. Compared to the control group, simvastatin-treated rats displayed a higher bursting pressure (p < 0.001) and anastomotic hydroxyproline content (p < 0.05). Simvastatin treatment leads to a significant decrease in malondealdehyde levels (p < 0.05) and increase in paraoxonase activity (p < 0.001) at both time points. Histopathological analysis revealed that simvastatin administration leads to a better anastomotic healing in terms of reepithelialization, decreased granuloma formation, reduced ischemic necrosis, and inflammatory infiltration to muscle layer. Clinically relevant doses of simvastatin do not have a negative impact on colonic anastomosis but improve intestinal wound healing in rats.

Yazar Cakmak, G. Karadeniz
Irkorucu, O.
Ucan, B. H.
Emre, A. U.
Bahadir, B.
Demirtas, C.
Tascilar, O.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3334
Tek Biçim Adres 10.1007/s11605-009-0951-2
Konu Başlıkları Simvastatin
Wound healing
Anatomosis
Dehiscence
Bursting pressure
Hydroxyproline
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF GASTROINTESTINAL SURGERY
Dergi Cilt Bilgisi 13
Dergi Sayısı 9
Sayfalar 1707 - 1716
Yayın Yılı 2009
Eser Adı
[dc.title]
Simvastatin Improves Wound Strength after Intestinal Anastomosis in the Rat
Yazar
[dc.contributor.author]
Cakmak, G. Karadeniz
Yazar
[dc.contributor.author]
Irkorucu, O.
Yazar
[dc.contributor.author]
Ucan, B. H.
Yazar
[dc.contributor.author]
Emre, A. U.
Yazar
[dc.contributor.author]
Bahadir, B.
Yazar
[dc.contributor.author]
Demirtas, C.
Yazar
[dc.contributor.author]
Tascilar, O.
Yayın Yılı
[dc.date.issued]
2009
Yayıncı
[dc.publisher]
SPRINGER
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Simvastatin is a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor commonly known as a cholesterol-lowering drug with additional pleiotropic effects. Also, it is demonstrated that it prevents postoperative peritoneal adhesions in rat. This study was designed to assess its effects on the healing process of colonic anastomosis. Thirty-two male Wistar albino rats were randomized into two groups and subjected to colonic anastomosis. The study group was treated with simvastatin and the control group received only tap water instead. The rats were killed 3 and 7 days postoperatively. Wound complications, intra-abdominal abscesses, and anastomotic leaks and stenosis were recorded. Four types of assessment were performed: bursting pressure, hydroxyproline content, histopathology, and biochemical analysis. Compared to the control group, simvastatin-treated rats displayed a higher bursting pressure (p < 0.001) and anastomotic hydroxyproline content (p < 0.05). Simvastatin treatment leads to a significant decrease in malondealdehyde levels (p < 0.05) and increase in paraoxonase activity (p < 0.001) at both time points. Histopathological analysis revealed that simvastatin administration leads to a better anastomotic healing in terms of reepithelialization, decreased granuloma formation, reduced ischemic necrosis, and inflammatory infiltration to muscle layer. Clinically relevant doses of simvastatin do not have a negative impact on colonic anastomosis but improve intestinal wound healing in rats.
Açıklama
[dc.description]
Annual Congress on Turkish National Surgery -- MAY, 2008 -- Antalya, TURKEY
Açıklama
[dc.description]
WOS: 000268575000024
Açıklama
[dc.description]
PubMed: 19578821
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Simvastatin
Konu Başlıkları
[dc.subject]
Wound healing
Konu Başlıkları
[dc.subject]
Anatomosis
Konu Başlıkları
[dc.subject]
Dehiscence
Konu Başlıkları
[dc.subject]
Bursting pressure
Konu Başlıkları
[dc.subject]
Hydroxyproline
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1091-255X
ISSN
[dc.identifier.issn]
1873-4626
İlk Sayfa Sayısı
[dc.identifier.startpage]
1707
Son Sayfa Sayısı
[dc.identifier.endpage]
1716
Dergi Adı
[dc.relation.journal]
JOURNAL OF GASTROINTESTINAL SURGERY
Dergi Sayısı
[dc.identifier.issue]
9
Dergi Cilt Bilgisi
[dc.identifier.volume]
13
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1007/s11605-009-0951-2
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3334
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
17
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Şubat 2024 23:26
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Tıklayınız
colonic anastomotic healing simvastatin anastomosis hydroxyproline control analysis content bursting Simvastatin effects pressure reduced impact decrease significant treatment negative higher levels displayed simvastatin-treated Compared improve biochemical histopathology intestinal malondealdehyde increase ischemic muscle necrosis inflammatory infiltration
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