Comparison of Propofol, Propofol-Remifentanil, and Propofol-Fentanyl Administrations with Each Other Used for the Sedation of Patients to Undergo ERCP

Introduction. Using single anesthetic agent in endoscopic retrograde cholangiopancreatography (ERCP) may lead to inadequate analgesia and sedation. To achieve the adequate analgesia and sedation the single anesthetic agent doses must be increased which causes undesirable side effects. For avoiding high doses of single anesthetic agent nowadays combination with sedative agents is mostly a choice for analgesia and sedation for ERCP. Aim. The aim of this study is to investigate the effects of propofol alone, propofol + remifentanil, and propofol + fentanyl combinations on the total dose of propofol to be administered during ERCP and on the pain scores after the process. Materials and Method. This randomized study was performed with 90 patients (ASA I-II-III) ranging between 18 and 70 years of age who underwent sedation/analgesia for elective ERCP. The patients were administered only propofol (1.5mg/kg) in Group., remifentanil (0.05 mu g/kg) + propofol (1.5mg/kg) combination in Group II, and fentanyl (1 mu g/kg) + propofol (1.5mg/kg) combination in Group III. All the patients' sedation levels were assessed with the Ramsey Sedation Scale (RSS). Their recovery was assessed with the Aldrete and Numerical Rating Scale Score (NRS) at 10 min intervals. Results. The total doses of propofol administered to the patients in the three groups in this study were as follows: 375mg in Group I, 150mg in Group II, and 245mg in Group III. Conclusion. It was observed that, in the patients undergoing ERCP, administration of propofol in combination with an opioid provided effective and reliable sedation, reduced the total dose of propofol, increased the practitioner satisfaction, decreased the pain level, and provided hemodynamic stability compared to the administration of propofol alone.

Yazar Haytural, Candan
Aydinli, Bahar
Demir, Berna
Bozkurt, Elif
Parlak, Erkan
Disibeyaz, Selcuk
Sarac, Ahmet
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2276
Tek Biçim Adres 10.1155/2015/465465
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı BIOMED RESEARCH INTERNATIONAL
Sayfalar -
Yayın Yılı 2015
Eser Adı
[dc.title]
Comparison of Propofol, Propofol-Remifentanil, and Propofol-Fentanyl Administrations with Each Other Used for the Sedation of Patients to Undergo ERCP
Yazar
[dc.contributor.author]
Haytural, Candan
Yazar
[dc.contributor.author]
Aydinli, Bahar
Yazar
[dc.contributor.author]
Demir, Berna
Yazar
[dc.contributor.author]
Bozkurt, Elif
Yazar
[dc.contributor.author]
Parlak, Erkan
Yazar
[dc.contributor.author]
Disibeyaz, Selcuk
Yazar
[dc.contributor.author]
Sarac, Ahmet
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
HINDAWI PUBLISHING CORP
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction. Using single anesthetic agent in endoscopic retrograde cholangiopancreatography (ERCP) may lead to inadequate analgesia and sedation. To achieve the adequate analgesia and sedation the single anesthetic agent doses must be increased which causes undesirable side effects. For avoiding high doses of single anesthetic agent nowadays combination with sedative agents is mostly a choice for analgesia and sedation for ERCP. Aim. The aim of this study is to investigate the effects of propofol alone, propofol + remifentanil, and propofol + fentanyl combinations on the total dose of propofol to be administered during ERCP and on the pain scores after the process. Materials and Method. This randomized study was performed with 90 patients (ASA I-II-III) ranging between 18 and 70 years of age who underwent sedation/analgesia for elective ERCP. The patients were administered only propofol (1.5mg/kg) in Group., remifentanil (0.05 mu g/kg) + propofol (1.5mg/kg) combination in Group II, and fentanyl (1 mu g/kg) + propofol (1.5mg/kg) combination in Group III. All the patients' sedation levels were assessed with the Ramsey Sedation Scale (RSS). Their recovery was assessed with the Aldrete and Numerical Rating Scale Score (NRS) at 10 min intervals. Results. The total doses of propofol administered to the patients in the three groups in this study were as follows: 375mg in Group I, 150mg in Group II, and 245mg in Group III. Conclusion. It was observed that, in the patients undergoing ERCP, administration of propofol in combination with an opioid provided effective and reliable sedation, reduced the total dose of propofol, increased the practitioner satisfaction, decreased the pain level, and provided hemodynamic stability compared to the administration of propofol alone.
Açıklama
[dc.description]
WOS: 000364066300001
Açıklama
[dc.description]
PubMed: 26576424
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2314-6133
ISSN
[dc.identifier.issn]
2314-6141
Dergi Adı
[dc.relation.journal]
BIOMED RESEARCH INTERNATIONAL
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1155/2015/465465
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2276
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
7
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
24 Eylül 2023 16:17
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Tıklayınız
propofol patients sedation combination administered 5mg/kg) single anesthetic analgesia assessed fentanyl remifentanil increased provided administration effects levels Rating compared stability Numerical Aldrete recovery Sedation Ramsey opioid intervals undergoing observed Conclusion effective follows reliable groups reduced
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