Hormone receptor status and survival of medullary breast cancer patients

Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uniand multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p>0.05). Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.

Yazar Aksoy, Asude
Odabas, Hatice
Kaya, Serap
Bozkurt, Oktay
Degirmenci, Mustafa
Topcu, Turkan O.
Aytekin, Aydin
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2732
Tek Biçim Adres 10.15537/smj.2017.2.18055
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı SAUDI MEDICAL JOURNAL
Dergi Cilt Bilgisi 38
Dergi Sayısı 2
Sayfalar 156 - 162
Yayın Yılı 2017
Eser Adı
[dc.title]
Hormone receptor status and survival of medullary breast cancer patients
Yazar
[dc.contributor.author]
Aksoy, Asude
Yazar
[dc.contributor.author]
Odabas, Hatice
Yazar
[dc.contributor.author]
Kaya, Serap
Yazar
[dc.contributor.author]
Bozkurt, Oktay
Yazar
[dc.contributor.author]
Degirmenci, Mustafa
Yazar
[dc.contributor.author]
Topcu, Turkan O.
Yazar
[dc.contributor.author]
Aytekin, Aydin
Yayın Yılı
[dc.date.issued]
2017
Yayıncı
[dc.publisher]
SAUDI MED J
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives: To analyze the relationship between clinical features, hormonal receptor status, and survival in patients who were diagnosed with medullary breast cancer (MBC). Methods: Demographic characteristics, histopathological features, and survival statuses of 201 patients diagnosed with MBC between 1995 and 2015 were retrospectively recorded. Survival analyses were conducted with uniand multivariate cox regression analysis. Results: Median follow-up time was 54 (4-272) months. Median patient age at the time of diagnosis was 47 years old (26-90). Of the patients, 91.5% were triple negative. Five-year recurrence free survival time (RFS) rate was 87.4% and overalll survival (OS) rate 95.7%. For RFS, progesterone receptor (PR) negativity, atypical histopathological evaluation, absence of lymphovascular invasion, smaller tumor, lower nodal involvement were found to be favourable prognostic factors by univariate analysis (p<0.05). The PR negativity and smaller tumor were found to be favourable factors by univariate analysis (p<0.05). However, none of these factors were determined as significant independent prognostic factors for OS (p>0.05). Conclusion: Turkish MBC patients exhibited good prognosis, which was comparable with survival outcomes achieved in the literature. The PR negativity was related to a better RFS and OS rates.
Açıklama
[dc.description]
WOS: 000395637900006
Açıklama
[dc.description]
PubMed: 28133688
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0379-5284
İlk Sayfa Sayısı
[dc.identifier.startpage]
156
Son Sayfa Sayısı
[dc.identifier.endpage]
162
Dergi Adı
[dc.relation.journal]
SAUDI MEDICAL JOURNAL
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.15537/smj.2017.2.18055
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2732
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
9
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 21:57
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survival patients factors negativity analysis prognostic favourable Median univariate smaller receptor between diagnosed features histopathological progesterone atypical evaluation absence lymphovascular invasion involvement Objectives determined However prognosis better related literature achieved outcomes comparable exhibited Turkish Conclusion
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