Influence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations

OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.

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Eser Adı
(dc.title)
Influence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations
Yazar
(dc.contributor.author)
Ozbilgin, Mahmut Kemal
Yazar
(dc.contributor.author)
Aktas, Caner
Yazar
(dc.contributor.author)
Uluer, Elgin Turkoz
Yazar
(dc.contributor.author)
Buyukuysal, Mustafa Cagatay
Yazar
(dc.contributor.author)
Gareveran, Manuchehr Salehi
Yazar
(dc.contributor.author)
Kurtman, Cengiz
Yayın Yılı
(dc.date.issued)
2016
Yayıncı
(dc.publisher)
SCI PRINTERS & PUBL INC
Yayın Türü
(dc.type)
article
Özet
(dc.description.abstract)
OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.
Açıklama
(dc.description)
WOS: 000381062200009
Açıklama
(dc.description)
PubMed: 27386634
Kayıt Giriş Tarihi
(dc.date.accessioned)
2019-12-23

(dc.date.available)
2019-12-23
Yayın Dili
(dc.language.iso)
eng
Konu Başlıkları
(dc.subject)
cancer
Konu Başlıkları
(dc.subject)
carcinogens
Konu Başlıkları
(dc.subject)
HB-EGF
Konu Başlıkları
(dc.subject)
heparin-binding EGF-like growth factor
Konu Başlıkları
(dc.subject)
radiation
Konu Başlıkları
(dc.subject)
radio-therapy
Konu Başlıkları
(dc.subject)
targeted radiotherapy
Konu Başlıkları
(dc.subject)
versican
Haklar
(dc.rights)
info:eu-repo/semantics/closedAccess
ISSN
(dc.identifier.issn)
0884-6812
İlk Sayfa Sayısı
(dc.identifier.startpage)
126
Son Sayfa Sayısı
(dc.identifier.endpage)
132
Dergi Adı
(dc.relation.journal)
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
Dergi Sayısı
(dc.identifier.issue)
2
Dergi Cilt Bilgisi
(dc.identifier.volume)
38
Tek Biçim Adres
(dc.identifier.uri)
https://hdl.handle.net/20.500.12628/2781
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