Influence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations

OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.

Yazar Ozbilgin, Mahmut Kemal
Aktas, Caner
Uluer, Elgin Turkoz
Buyukuysal, Mustafa Cagatay
Gareveran, Manuchehr Salehi
Kurtman, Cengiz
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2781
Konu Başlıkları cancer
carcinogens
HB-EGF
heparin-binding EGF-like growth factor
radiation
radio-therapy
targeted radiotherapy
versican
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
Dergi Cilt Bilgisi 38
Dergi Sayısı 2
Sayfalar 126 - 132
Yayın Yılı 2016
Eser Adı
[dc.title]
Influence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations
Yazar
[dc.contributor.author]
Ozbilgin, Mahmut Kemal
Yazar
[dc.contributor.author]
Aktas, Caner
Yazar
[dc.contributor.author]
Uluer, Elgin Turkoz
Yazar
[dc.contributor.author]
Buyukuysal, Mustafa Cagatay
Yazar
[dc.contributor.author]
Gareveran, Manuchehr Salehi
Yazar
[dc.contributor.author]
Kurtman, Cengiz
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
SCI PRINTERS & PUBL INC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.
Açıklama
[dc.description]
WOS: 000381062200009
Açıklama
[dc.description]
PubMed: 27386634
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
cancer
Konu Başlıkları
[dc.subject]
carcinogens
Konu Başlıkları
[dc.subject]
HB-EGF
Konu Başlıkları
[dc.subject]
heparin-binding EGF-like growth factor
Konu Başlıkları
[dc.subject]
radiation
Konu Başlıkları
[dc.subject]
radio-therapy
Konu Başlıkları
[dc.subject]
targeted radiotherapy
Konu Başlıkları
[dc.subject]
versican
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0884-6812
İlk Sayfa Sayısı
[dc.identifier.startpage]
126
Son Sayfa Sayısı
[dc.identifier.endpage]
132
Dergi Adı
[dc.relation.journal]
ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
38
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2781
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
35
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 11:50
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Tıklayınız
radiation exposure tissue samples radiotherapy effects observed bladder normal versican concentrations increase investigated device reference OBJECTIVE anti-HB-EGF exposed significant matrix HB-EGF CONCLUSION statistically RESULTS antibodies primary anti-versican examination immunohistochemical teletherapy region insight investigate reaction heparin-binding
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