OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy.
Eser Adı (dc.title) | Influence of Radiation Exposure During Radiotherapy Evidence for the Increase of Versican and Heparin-Binding EGF-like Growth Factor Concentrations |
Yazar (dc.contributor.author) | Ozbilgin, Mahmut Kemal |
Yazar (dc.contributor.author) | Aktas, Caner |
Yazar (dc.contributor.author) | Uluer, Elgin Turkoz |
Yazar (dc.contributor.author) | Buyukuysal, Mustafa Cagatay |
Yazar (dc.contributor.author) | Gareveran, Manuchehr Salehi |
Yazar (dc.contributor.author) | Kurtman, Cengiz |
Yayın Yılı (dc.date.issued) | 2016 |
Yayıncı (dc.publisher) | SCI PRINTERS & PUBL INC |
Yayın Türü (dc.type) | article |
Özet (dc.description.abstract) | OBJECTIVE: To investigate the reaction of versican and heparin-binding EGF-like growth factor (HB-EGF) molecule concentrations to acute radiation exposure in normal bladder and rectal tissue samples in order to gain more insight into the effects of cancer radiotherapy. STUDY DESIGN: Four groups with 6 male adult Swiss Albino mice per group were investigated. The mice bladder and rectum tissue samples were subjected to a 10-Gy single-dose radiation exposure in the pelvic region with a Co-60 teletherapy device and investigated 1, 2, and 7 days after radiation exposure, with 1 reference group which was not exposed to radiation. RESULTS: In the immunohistochemical examination of the tissue samples with anti-versican and anti-HB-EGF primary antibodies was observed a statistically significant increase 7 days after radiation exposure. CONCLUSION: The observed increase of versican and HB-EGF concentrations in the normal tissue matrix after radiation exposure may play a role in the side effects of radiotherapy. |
Açıklama (dc.description) | WOS: 000381062200009 |
Açıklama (dc.description) | PubMed: 27386634 |
Kayıt Giriş Tarihi (dc.date.accessioned) | 2019-12-23 |
(dc.date.available) | 2019-12-23 |
Yayın Dili (dc.language.iso) | eng |
Konu Başlıkları (dc.subject) | cancer |
Konu Başlıkları (dc.subject) | carcinogens |
Konu Başlıkları (dc.subject) | HB-EGF |
Konu Başlıkları (dc.subject) | heparin-binding EGF-like growth factor |
Konu Başlıkları (dc.subject) | radiation |
Konu Başlıkları (dc.subject) | radio-therapy |
Konu Başlıkları (dc.subject) | targeted radiotherapy |
Konu Başlıkları (dc.subject) | versican |
Haklar (dc.rights) | info:eu-repo/semantics/closedAccess |
ISSN (dc.identifier.issn) | 0884-6812 |
İlk Sayfa Sayısı (dc.identifier.startpage) | 126 |
Son Sayfa Sayısı (dc.identifier.endpage) | 132 |
Dergi Adı (dc.relation.journal) | ANALYTICAL AND QUANTITATIVE CYTOPATHOLOGY AND HISTOPATHOLOGY |
Dergi Sayısı (dc.identifier.issue) | 2 |
Dergi Cilt Bilgisi (dc.identifier.volume) | 38 |
Tek Biçim Adres (dc.identifier.uri) | https://hdl.handle.net/20.500.12628/2781 |