The Effects of Lidocaine with Epinephrine on Bupivacaine-Induced Cardiotoxicity

Objective: Bupivacaine, a local anaesthetic substance, is used as a regional-anaesthesia agent. Lidocaine, a sodium channel blocker, is used in combination with epinephrine for regional anaesthesia. We aimed to evaluate the effects of lidocaine with epinephrine (LE) at different doses on bupivacaine-induced cardiotoxicity in rats. Methods: In our study, 24 Wistar albino rats were divided into four groups: I) Control; II) LE, 1 mg kg(-1); III) LE, 3 mg kg(-1) and IV) LE, 6 mg kg(-1). Intravenous bupivacaine was administered at a dose of 3 mg kg(-1) min(-1) to the anaesthetized rats in all groups until cardiac asystole was achieved. LE was administered at the doses of 1, 3 and 6 mg kg(-1) min(-1) using infusion, simultaneously with bupivacaine. The asystole time and 75% decrement time in mean arterial blood pressure (MABP) were determined. P-Q, Q-T and QRS intervals were measured using electrocardiography (ECG) recordings. Results: LE significantly increased the asystole time and 75% decrement time in MABP at the doses of 3 and 6 mg kg(-1) compared to the control group (p<0.05) and significantly increased these values at the dose of 1 mg kg(-1) compared to the control and other treatment groups (p<0.05). LE abolished the prolongation of P-Q, Q-T and QRS intervals in ECG recordings at the dose of 1 mg kg(-1) (p<0.05). Conclusion: These results reveal that LE has a protective effect against bupivacaine cardiotoxicity. In clinical application, the simultaneous application of LE and bupivacaine may reduce the risk of cardiotoxicity due to bupivacaine.

Dergi Adı TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
Dergi Cilt Bilgisi 46
Dergi Sayısı 6
Sayfalar 447 - 452
Yayın Yılı 2018
Eser Adı
[dc.title]
The Effects of Lidocaine with Epinephrine on Bupivacaine-Induced Cardiotoxicity
Yazar
[dc.contributor.author]
Gonca, Ersoz
Yazar
[dc.contributor.author]
Catli, Duygu
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
AVES
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: Bupivacaine, a local anaesthetic substance, is used as a regional-anaesthesia agent. Lidocaine, a sodium channel blocker, is used in combination with epinephrine for regional anaesthesia. We aimed to evaluate the effects of lidocaine with epinephrine (LE) at different doses on bupivacaine-induced cardiotoxicity in rats. Methods: In our study, 24 Wistar albino rats were divided into four groups: I) Control; II) LE, 1 mg kg(-1); III) LE, 3 mg kg(-1) and IV) LE, 6 mg kg(-1). Intravenous bupivacaine was administered at a dose of 3 mg kg(-1) min(-1) to the anaesthetized rats in all groups until cardiac asystole was achieved. LE was administered at the doses of 1, 3 and 6 mg kg(-1) min(-1) using infusion, simultaneously with bupivacaine. The asystole time and 75% decrement time in mean arterial blood pressure (MABP) were determined. P-Q, Q-T and QRS intervals were measured using electrocardiography (ECG) recordings. Results: LE significantly increased the asystole time and 75% decrement time in MABP at the doses of 3 and 6 mg kg(-1) compared to the control group (p<0.05) and significantly increased these values at the dose of 1 mg kg(-1) compared to the control and other treatment groups (p<0.05). LE abolished the prolongation of P-Q, Q-T and QRS intervals in ECG recordings at the dose of 1 mg kg(-1) (p<0.05). Conclusion: These results reveal that LE has a protective effect against bupivacaine cardiotoxicity. In clinical application, the simultaneous application of LE and bupivacaine may reduce the risk of cardiotoxicity due to bupivacaine.
Açıklama
[dc.description]
WOS: 000449525500008
Açıklama
[dc.description]
PubMed: 30505607
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bupivacaine
Konu Başlıkları
[dc.subject]
cardiotoxicity
Konu Başlıkları
[dc.subject]
lidocaine with epinephrine
Konu Başlıkları
[dc.subject]
rat
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
2149-0937
ISSN
[dc.identifier.issn]
2149-276X
Sponsor YAYINCI
[dc.description.sponsorship]
Bulent Ecevit University Coordinatorship of Scientific Research Projects [2016-84906727-02]
Sponsor YAYINCI
[dc.description.sponsorship]
This study was finacially supported by Bulent Ecevit University Coordinatorship of Scientific Research Projects (Project no: 2016-84906727-02).
İlk Sayfa Sayısı
[dc.identifier.startpage]
447
Son Sayfa Sayısı
[dc.identifier.endpage]
452
Dergi Adı
[dc.relation.journal]
TURKISH JOURNAL OF ANAESTHESIOLOGY AND REANIMATION
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
46
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5152/TJAR.2018.64624
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3562
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
19
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Nisan 2024 20:27
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Tıklayınız
kg(-1) bupivacaine asystole cardiotoxicity groups recordings intervals compared administered min(-1) decrement increased significantly control epinephrine application determined effect Conclusion results reveal (MABP) pressure prolongation arterial abolished against electrocardiography protective Results values measured simultaneous treatment clinical
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