Leptin levels in children with obstructive sleep apnea syndrome

Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of >= 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group. Results: 47 children (51% male and 49% female; mean age 7.8 +/- 2.6 years) were recruited. Twenty seven participants were diagnosed with moderate-to-severe OSAS, and twenty children who had AHI < 5 were included in the mild OSAS/primary snoring. The two groups did not differ regarding age, gender and body mass index z score (p> 0.05). Furthermore there were no differences in log serum leptin levels (p= 0.749). Log serum leptin levels correlated with the BMI z score in the whole study group (p= 0.001; r= 0.499) but they were not associated with apnea-hypopnea index, mean and lowest oxygen saturation during sleep. Conclusion: Serum leptin levels are affected by adiposity but not by OSAS severity among children with habitual snoring.

Yazar Sogut, Ayhan
Acikgoz, Serefden
Uzun, Lokman
Ugur, Mehmet Birol
Altin, Remzi
Dagli, Elif
Kaditis, Athanasios
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2877
Tek Biçim Adres 10.5578/tt.21009
Konu Başlıkları Leptin
obstructive sleep apnea syndrome
children
sleep apnea
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX
Dergi Cilt Bilgisi 64
Dergi Sayısı 4
Sayfalar 283 - 288
Yayın Yılı 2016
Eser Adı
[dc.title]
Leptin levels in children with obstructive sleep apnea syndrome
Yazar
[dc.contributor.author]
Sogut, Ayhan
Yazar
[dc.contributor.author]
Acikgoz, Serefden
Yazar
[dc.contributor.author]
Uzun, Lokman
Yazar
[dc.contributor.author]
Ugur, Mehmet Birol
Yazar
[dc.contributor.author]
Altin, Remzi
Yazar
[dc.contributor.author]
Dagli, Elif
Yazar
[dc.contributor.author]
Kaditis, Athanasios
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
TURKISH ASSOC TUBERCULOSIS & THORAX
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Introduction: The aim of this study is to assess the effect of obstructive sleep apnea syndrome (OSAS) severity on leptin levels in children. Patients and Methods: Children with habitual snoring underwent overnight polysomnography. Fasting venous blood samples were obtained between 8 AM and 9 AM, following the night of the sleep study. Children with an apnea-hypopnea index of >= 5/h were included in the moderate-to-severe OSAS group while those with an apnea-hypopnea index of < 5/h formed the mild OSAS/primary snoring group. Results: 47 children (51% male and 49% female; mean age 7.8 +/- 2.6 years) were recruited. Twenty seven participants were diagnosed with moderate-to-severe OSAS, and twenty children who had AHI < 5 were included in the mild OSAS/primary snoring. The two groups did not differ regarding age, gender and body mass index z score (p> 0.05). Furthermore there were no differences in log serum leptin levels (p= 0.749). Log serum leptin levels correlated with the BMI z score in the whole study group (p= 0.001; r= 0.499) but they were not associated with apnea-hypopnea index, mean and lowest oxygen saturation during sleep. Conclusion: Serum leptin levels are affected by adiposity but not by OSAS severity among children with habitual snoring.
Açıklama
[dc.description]
WOS: 000395279400004
Açıklama
[dc.description]
PubMed: 28393717
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Leptin
Konu Başlıkları
[dc.subject]
obstructive sleep apnea syndrome
Konu Başlıkları
[dc.subject]
children
Konu Başlıkları
[dc.subject]
sleep apnea
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0494-1373
İlk Sayfa Sayısı
[dc.identifier.startpage]
283
Son Sayfa Sayısı
[dc.identifier.endpage]
288
Dergi Adı
[dc.relation.journal]
TUBERKULOZ VE TORAK-TUBERCULOSIS AND THORAX
Dergi Sayısı
[dc.identifier.issue]
4
Dergi Cilt Bilgisi
[dc.identifier.volume]
64
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5578/tt.21009
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2877
Görüntülenme Sayısı ( Şehir )
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Görüntülenme
13
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
09 Şubat 2024 23:05
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Tıklayınız
leptin snoring children levels apnea-hypopnea OSAS/primary severity habitual Children included moderate-to-severe Furthermore groups differ regarding gender Introduction lowest adiposity affected Conclusion during saturation oxygen associated differences correlated samples venous Fasting polysomnography overnight underwent Methods Patients
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