Effects of insulin plus glucose pretreatment on bupivacaine cardiotoxicity in rats

A mistaken overdose of bupivacaine into systemic circulation may cause severe cardiovascular side effects. The aim of this study was to assess the effects of pretreatment with combined intra venous lipid emulsion (ILE) and high-dose insulin therapy against cardiotoxicity caused by bupivacaine intoxication. The rats were divided into the following three groups: Group B received a saline pretreatment plus a bupivacaine, group L received ILE pretreatment plus a bupivacaine, and in group I, insulin with glucose was infused intravenously, plus ILE pretreatment plus a bupivacaine. The electrocardiogram tracing, invasive arterial pressure, and heart rate (HR) of rats were monitored continuously. Arterial blood gas analysis was performed in all groups. Arterial blood gas analysis revealed that the baseline pH, PaO2, and PaCO2 values were similar between groups (p > 0.05). Widening of Q, R, and S wave complex was found 46.8 +/- 16.7, 92.0 +/- 5.80, and 106.5 +/- 17.9 s after initiation of bupivacaine infusion in groups B, L, and I, respectively. Time elapsed until 25% reduction of HR 127.3 +/- 17.7, 248.4 +/- 34.1, and 260.1 +/- 51.3 s for groups B, L, and I, and 25% reduction of mean arterial pressure 107.6 +/- 14.1, 253.2 +/- 36.3, and 292 +/- 57.7 s for groups B, L, and I, respectively. Arrhythmia was observed after 142.2 +/- 27.5, 180.7 +/- 17.8, and 190.7 +/- 19.2 s for groups B, L, and I, respectively. Finally, asystole occurred after 560.1 +/- 76.4, 782.4 +/- 63.0, and 882.5 +/- 105.1 s for groups B, L, and I, respectively. This finding indicates that the survival time of rats administered pretreatment with ILE plus insulin+glucose and those given ILE was observed to be longer.

Dergi Adı HUMAN & EXPERIMENTAL TOXICOLOGY
Dergi Cilt Bilgisi 37
Dergi Sayısı 5
Sayfalar 451 - 457
Yayın Yılı 2018
Eser Adı
[dc.title]
Effects of insulin plus glucose pretreatment on bupivacaine cardiotoxicity in rats
Yazar
[dc.contributor.author]
Piskin, O.
Yazar
[dc.contributor.author]
Aydin, B. G.
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
SAGE PUBLICATIONS LTD
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
A mistaken overdose of bupivacaine into systemic circulation may cause severe cardiovascular side effects. The aim of this study was to assess the effects of pretreatment with combined intra venous lipid emulsion (ILE) and high-dose insulin therapy against cardiotoxicity caused by bupivacaine intoxication. The rats were divided into the following three groups: Group B received a saline pretreatment plus a bupivacaine, group L received ILE pretreatment plus a bupivacaine, and in group I, insulin with glucose was infused intravenously, plus ILE pretreatment plus a bupivacaine. The electrocardiogram tracing, invasive arterial pressure, and heart rate (HR) of rats were monitored continuously. Arterial blood gas analysis was performed in all groups. Arterial blood gas analysis revealed that the baseline pH, PaO2, and PaCO2 values were similar between groups (p > 0.05). Widening of Q, R, and S wave complex was found 46.8 +/- 16.7, 92.0 +/- 5.80, and 106.5 +/- 17.9 s after initiation of bupivacaine infusion in groups B, L, and I, respectively. Time elapsed until 25% reduction of HR 127.3 +/- 17.7, 248.4 +/- 34.1, and 260.1 +/- 51.3 s for groups B, L, and I, and 25% reduction of mean arterial pressure 107.6 +/- 14.1, 253.2 +/- 36.3, and 292 +/- 57.7 s for groups B, L, and I, respectively. Arrhythmia was observed after 142.2 +/- 27.5, 180.7 +/- 17.8, and 190.7 +/- 19.2 s for groups B, L, and I, respectively. Finally, asystole occurred after 560.1 +/- 76.4, 782.4 +/- 63.0, and 882.5 +/- 105.1 s for groups B, L, and I, respectively. This finding indicates that the survival time of rats administered pretreatment with ILE plus insulin+glucose and those given ILE was observed to be longer.
Açıklama
[dc.description]
WOS: 000429812900001
Açıklama
[dc.description]
PubMed: 28565972
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Bupivacaine
Konu Başlıkları
[dc.subject]
cardiotoxicity
Konu Başlıkları
[dc.subject]
intra venous lipid emulsion (ILE)
Konu Başlıkları
[dc.subject]
insulin
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0960-3271
ISSN
[dc.identifier.issn]
1477-0903
İlk Sayfa Sayısı
[dc.identifier.startpage]
451
Son Sayfa Sayısı
[dc.identifier.endpage]
457
Dergi Adı
[dc.relation.journal]
HUMAN & EXPERIMENTAL TOXICOLOGY
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
37
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1177/0960327117712384
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2493
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
122
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
15 Temmuz 2024 22:29
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Tıklayınız
groups bupivacaine pretreatment respectively reduction observed received effects analysis insulin Arterial arterial pressure elapsed infusion initiation longer occurred finding asystole Finally Arrhythmia indicates survival administered insulin+glucose values venous following divided intoxication caused cardiotoxicity against therapy
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