Nasal obstruction as a common side-effect of sildenafil citrate

Sildenafil citrate is an effective oral drug for erectile dysfunction. The main action of sildenafil is the enhancement of the effect of nitric oxide (NO) by inhibiting the cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase-5 (PDE-5). an enzyme responsible for degradation of cGMP. NO is also present in the nasal mucosa and is responsible for vasodilation causing congestion and nasal obstruction. The aim of this study was to detect the effect of sildenafil on nasal mucosa in terms of nasal obstruction. A total of 16 patients presented to urology clinic suffering from impotence and medicated with sildenafil were included in the study. Before and after oral administration of 50 mg sildenafil, in all of the patients the nasal patency was examined by active anterior rhinomanometry (a method of assessing nasal resistance) using air pressure of 150 Pascal. In addition, all patients were asked about their sensation of nasal patency to detect the symptomatic nasal obstruction. There was a significant decrease in nasal air flow values (cm(3)/s) (p < 0.05). Except for three cases, all patients indicated that they had the sensation of nasal obstruction after the use of sildenafil (p < 0.05). Nasal obstruction is a common complaint for the patients using Sildenafil.

Yazar Kiroglu, AF
Bayrakli, H
Yuca, K
Cankaya, H
Kiris, M
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2978
Tek Biçim Adres 10.1620/tjem.208.251
Konu Başlıkları sildenafil
nasal patency
obstruction
rhinomanometry
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Dergi Cilt Bilgisi 208
Dergi Sayısı 3
Sayfalar 251 - 254
Yayın Yılı 2006
Eser Adı
[dc.title]
Nasal obstruction as a common side-effect of sildenafil citrate
Yazar
[dc.contributor.author]
Kiroglu, AF
Yazar
[dc.contributor.author]
Bayrakli, H
Yazar
[dc.contributor.author]
Yuca, K
Yazar
[dc.contributor.author]
Cankaya, H
Yazar
[dc.contributor.author]
Kiris, M
Yayın Yılı
[dc.date.issued]
2006
Yayıncı
[dc.publisher]
TOHOKU UNIV MEDICAL PRESS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Sildenafil citrate is an effective oral drug for erectile dysfunction. The main action of sildenafil is the enhancement of the effect of nitric oxide (NO) by inhibiting the cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase-5 (PDE-5). an enzyme responsible for degradation of cGMP. NO is also present in the nasal mucosa and is responsible for vasodilation causing congestion and nasal obstruction. The aim of this study was to detect the effect of sildenafil on nasal mucosa in terms of nasal obstruction. A total of 16 patients presented to urology clinic suffering from impotence and medicated with sildenafil were included in the study. Before and after oral administration of 50 mg sildenafil, in all of the patients the nasal patency was examined by active anterior rhinomanometry (a method of assessing nasal resistance) using air pressure of 150 Pascal. In addition, all patients were asked about their sensation of nasal patency to detect the symptomatic nasal obstruction. There was a significant decrease in nasal air flow values (cm(3)/s) (p < 0.05). Except for three cases, all patients indicated that they had the sensation of nasal obstruction after the use of sildenafil (p < 0.05). Nasal obstruction is a common complaint for the patients using Sildenafil.
Açıklama
[dc.description]
20th Congress of the European-Rhinologic-Society/23rd International Symposium on Infection and Allergy of the Nose -- JUN 18-25, 2004 -- Istanbul, TURKEY
Açıklama
[dc.description]
WOS: 000235535800008
Açıklama
[dc.description]
PubMed: 16498233
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
sildenafil
Konu Başlıkları
[dc.subject]
nasal patency
Konu Başlıkları
[dc.subject]
obstruction
Konu Başlıkları
[dc.subject]
rhinomanometry
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0040-8727
ISSN
[dc.identifier.issn]
1349-3329
Sponsor YAYINCI
[dc.description.sponsorship]
European Rhinol Soc
İlk Sayfa Sayısı
[dc.identifier.startpage]
251
Son Sayfa Sayısı
[dc.identifier.endpage]
254
Dergi Adı
[dc.relation.journal]
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Dergi Sayısı
[dc.identifier.issue]
3
Dergi Cilt Bilgisi
[dc.identifier.volume]
208
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1620/tjem.208.251
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2978
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 00:48
Google Kontrol
Tıklayınız
obstruction patients sildenafil detect sensation mucosa patency responsible Sildenafil effect examined pressure common assessing resistance) method complaint rhinomanometry anterior active Pascal values decrease significant symptomatic Except indicated addition (cm(3)/s) urology inhibiting degradation enzyme (PDE-5) phosphodiesterase-5
6698 sayılı Kişisel Verilerin Korunması Kanunu kapsamında yükümlülüklerimiz ve çerez politikamız hakkında bilgi sahibi olmak için alttaki bağlantıyı kullanabilirsiniz.

creativecommons
Bu site altında yer alan tüm kaynaklar Creative Commons Alıntı-GayriTicari-Türetilemez 4.0 Uluslararası Lisansı ile lisanslanmıştır.
Platforms