EFFECTS OF FENTANYL-LIDOCAINE-PROPOFOL AND DEXMEDETOMIDINE-LIDOCAINE-PROPOFOL ON TRACHEAL INTUBATION WITHOUT USE OF MUSCLE RELAXANTS

The aim of this study was to compare the effects of fentanyl or dexmedetomidine when used in combination with propofol and lidocaine for tracheal intubation without using muscle relaxants. Sixty patients with American Society of Anesthesiologists stage I risk were randomized to receive 1 mu g/kg dexmedetomidine (Group D, n = 30) or 2 mu g/kg fentanyl (Group F, n = 30), both in combination with 1.5 mg/kg lidocaine and 3 mg/kg propofol. The requirement for intubation was determined based on mask ventilation capability, jaw motility, position of the vocal cords and the patient's response to intubation and inflation of the endotracheal tube cuff. Systolic arterial pressure, mean arterial pressure, heart rate and peripheral oxygen saturation values were also recorded. Rate pressure products were calculated. Jaw relaxation, position of the vocal cords and patient's response to intubation and inflation of the endotracheal tube cuff were significantly better in Group D than in Group F (p < 0.05). The intubation conditions were significantly more satisfactory in Group D than in Group F (p = 0.01). Heart rate was significantly lower in Group D than in Group F after the administration of the study drugs and intubation (p < 0.05). Mean arterial pressure was significantly lower in Group F than in Group D after propofol injection and at 3 and 5 minutes after intubation (p < 0.05). After intubation, the rate pressure product values were significantly lower in Group D than in Group F (p < 0.05). We conclude that endotracheal intubation was better with the dexmedetomidine lidocaine propofol combination than with the fentanyl lidocaine propofol combination. However, side effects such as bradycardia should be considered when using dexmedetomidine.

Yazar Hanci, Volkan
Erdogan, Guelay
Okyay, Rahsan Dilek
Yurtlu, Buelent Serhan
Ayoglu, Hilal
Baydilek, Yunus
Turan, Isil Oezkocak
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2489
Tek Biçim Adres 10.1016/S1607-551X(10)70035-8
Konu Başlıkları dexmedetomidine
fentanyl
neuromuscular blocking agents
rate pressure products
tracheal intubation
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Dergi Cilt Bilgisi 26
Dergi Sayısı 5
Sayfalar 244 - 250
Yayın Yılı 2010
Eser Adı
[dc.title]
EFFECTS OF FENTANYL-LIDOCAINE-PROPOFOL AND DEXMEDETOMIDINE-LIDOCAINE-PROPOFOL ON TRACHEAL INTUBATION WITHOUT USE OF MUSCLE RELAXANTS
Yazar
[dc.contributor.author]
Hanci, Volkan
Yazar
[dc.contributor.author]
Erdogan, Guelay
Yazar
[dc.contributor.author]
Okyay, Rahsan Dilek
Yazar
[dc.contributor.author]
Yurtlu, Buelent Serhan
Yazar
[dc.contributor.author]
Ayoglu, Hilal
Yazar
[dc.contributor.author]
Baydilek, Yunus
Yazar
[dc.contributor.author]
Turan, Isil Oezkocak
Yayın Yılı
[dc.date.issued]
2010
Yayıncı
[dc.publisher]
KAOHSIUNG JOURNAL MEDICAL SCIENCES
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
The aim of this study was to compare the effects of fentanyl or dexmedetomidine when used in combination with propofol and lidocaine for tracheal intubation without using muscle relaxants. Sixty patients with American Society of Anesthesiologists stage I risk were randomized to receive 1 mu g/kg dexmedetomidine (Group D, n = 30) or 2 mu g/kg fentanyl (Group F, n = 30), both in combination with 1.5 mg/kg lidocaine and 3 mg/kg propofol. The requirement for intubation was determined based on mask ventilation capability, jaw motility, position of the vocal cords and the patient's response to intubation and inflation of the endotracheal tube cuff. Systolic arterial pressure, mean arterial pressure, heart rate and peripheral oxygen saturation values were also recorded. Rate pressure products were calculated. Jaw relaxation, position of the vocal cords and patient's response to intubation and inflation of the endotracheal tube cuff were significantly better in Group D than in Group F (p < 0.05). The intubation conditions were significantly more satisfactory in Group D than in Group F (p = 0.01). Heart rate was significantly lower in Group D than in Group F after the administration of the study drugs and intubation (p < 0.05). Mean arterial pressure was significantly lower in Group F than in Group D after propofol injection and at 3 and 5 minutes after intubation (p < 0.05). After intubation, the rate pressure product values were significantly lower in Group D than in Group F (p < 0.05). We conclude that endotracheal intubation was better with the dexmedetomidine lidocaine propofol combination than with the fentanyl lidocaine propofol combination. However, side effects such as bradycardia should be considered when using dexmedetomidine.
Açıklama
[dc.description]
WOS: 000277766100003
Açıklama
[dc.description]
PubMed: 20466334
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
dexmedetomidine
Konu Başlıkları
[dc.subject]
fentanyl
Konu Başlıkları
[dc.subject]
neuromuscular blocking agents
Konu Başlıkları
[dc.subject]
rate pressure products
Konu Başlıkları
[dc.subject]
tracheal intubation
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1607-551X
İlk Sayfa Sayısı
[dc.identifier.startpage]
244
Son Sayfa Sayısı
[dc.identifier.endpage]
250
Dergi Adı
[dc.relation.journal]
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
26
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1016/S1607-551X(10)70035-8
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2489
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
15
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 17:32
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Tıklayınız
intubation propofol pressure significantly dexmedetomidine combination lidocaine endotracheal fentanyl arterial patient position response better inflation values effects (Group However considered should relaxation bradycardia administration calculated satisfactory conditions conclude injection minutes product motility products patients randomized
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