Evaluation of gingival crevicular fluid levels of tissue plasminogen activator, plasminogen activator inhibitor 2, matrix metalloproteinase-3 and interleukin 1-beta in patients with different periodontal diseases

ObjectivesThe purpose of this study was to evaluate the gingival crevicular fluid levels of interleukin-1beta (IL-1), matrix metalloproteinases-3 (MMP-3), tissue type plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) in patients with chronic periodontitis, aggressive periodontitis (AgP) and healthy individuals (controls). Material and MethodsSystemically healthy (21 chronic periodontitis, 23 AgP and 20 controls) subjects were included in this study. Plaque index, gingival index, probing pocket depth and clinical attachment level were recorded and gingival crevicular fluid samples were collected. Assays for IL-1, MMP-3, t-PA and PAI-2 levels in gingival crevicular fluid were carried out by an enzyme-linked immunosorbent assay. The one-sample Kolmogorov-Smirnov test, Mann-Whitney U test and Spearman correlation coefficient were used for data analyses. ResultsGingival crevicular fluid levels of t-PA and IL-1 were significantly higher in chronic periodontitis and AgP groups than in the control group (p<0.001). MMP-3 levels in gingival crevicular fluid were detected as significantly higher in the chronic periodontitis and AgP groups compared with the control group (p<0.05). The t-PA/PAI-2 rate of patients with chronic periodontitis and AgP were significantly higher than the control group (p<0.05). The positive correlations were found among the PAI-2, t-PA, IL-1 and MMP-3 levels in gingival crevicular fluid. The volume of the gingival crevicular fluid correlated with all of the clinical parameters (p<0.001). There were positive correlations between the gingival crevicular fluid levels of PAI-2 and the probing pocket depth and between gingival crevicular fluid levels of PAI-2 and the clinical attachment level (p<0.01). Similarly, significant correlations were found between t-PA levels and probing pocket depth and between t-PA levels and clinical attachment level measurements (p<0.001). ConclusionThe present data showed that gingival crevicular fluid levels of IL-1 , MMP-3 and t-PA increased in periodontal disease regardless of the periodontitis type and played a part in tissue destruction.

Yazar Toyman, U.
Tuter, G.
Kurtis, B.
Kivrak, E.
Bozkurt, S.
Yucel, A. A.
Serdar, M.
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2587
Tek Biçim Adres 10.1111/jre.12179
Konu Başlıkları interleukin-1beta
matrix metalloproteinase-3
plasminogen activator inhibitor 2
tissue plasminogen activator
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı JOURNAL OF PERIODONTAL RESEARCH
Dergi Cilt Bilgisi 50
Dergi Sayısı 1
Sayfalar 44 - 51
Yayın Yılı 2015
Eser Adı
[dc.title]
Evaluation of gingival crevicular fluid levels of tissue plasminogen activator, plasminogen activator inhibitor 2, matrix metalloproteinase-3 and interleukin 1-beta in patients with different periodontal diseases
Yazar
[dc.contributor.author]
Toyman, U.
Yazar
[dc.contributor.author]
Tuter, G.
Yazar
[dc.contributor.author]
Kurtis, B.
Yazar
[dc.contributor.author]
Kivrak, E.
Yazar
[dc.contributor.author]
Bozkurt, S.
Yazar
[dc.contributor.author]
Yucel, A. A.
Yazar
[dc.contributor.author]
Serdar, M.
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
WILEY
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
ObjectivesThe purpose of this study was to evaluate the gingival crevicular fluid levels of interleukin-1beta (IL-1), matrix metalloproteinases-3 (MMP-3), tissue type plasminogen activator (t-PA) and plasminogen activator inhibitor 2 (PAI-2) in patients with chronic periodontitis, aggressive periodontitis (AgP) and healthy individuals (controls). Material and MethodsSystemically healthy (21 chronic periodontitis, 23 AgP and 20 controls) subjects were included in this study. Plaque index, gingival index, probing pocket depth and clinical attachment level were recorded and gingival crevicular fluid samples were collected. Assays for IL-1, MMP-3, t-PA and PAI-2 levels in gingival crevicular fluid were carried out by an enzyme-linked immunosorbent assay. The one-sample Kolmogorov-Smirnov test, Mann-Whitney U test and Spearman correlation coefficient were used for data analyses. ResultsGingival crevicular fluid levels of t-PA and IL-1 were significantly higher in chronic periodontitis and AgP groups than in the control group (p<0.001). MMP-3 levels in gingival crevicular fluid were detected as significantly higher in the chronic periodontitis and AgP groups compared with the control group (p<0.05). The t-PA/PAI-2 rate of patients with chronic periodontitis and AgP were significantly higher than the control group (p<0.05). The positive correlations were found among the PAI-2, t-PA, IL-1 and MMP-3 levels in gingival crevicular fluid. The volume of the gingival crevicular fluid correlated with all of the clinical parameters (p<0.001). There were positive correlations between the gingival crevicular fluid levels of PAI-2 and the probing pocket depth and between gingival crevicular fluid levels of PAI-2 and the clinical attachment level (p<0.01). Similarly, significant correlations were found between t-PA levels and probing pocket depth and between t-PA levels and clinical attachment level measurements (p<0.001). ConclusionThe present data showed that gingival crevicular fluid levels of IL-1 , MMP-3 and t-PA increased in periodontal disease regardless of the periodontitis type and played a part in tissue destruction.
Açıklama
[dc.description]
WOS: 000347467600006
Açıklama
[dc.description]
PubMed: 24690077
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
interleukin-1beta
Konu Başlıkları
[dc.subject]
matrix metalloproteinase-3
Konu Başlıkları
[dc.subject]
plasminogen activator inhibitor 2
Konu Başlıkları
[dc.subject]
tissue plasminogen activator
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
0022-3484
ISSN
[dc.identifier.issn]
1600-0765
Sponsor YAYINCI
[dc.description.sponsorship]
Scientific Research Foundation of Gazi UniversityGazi University [03/2006-19]; Gazi University research grantGazi University [03/2006-19]
Sponsor YAYINCI
[dc.description.sponsorship]
This research was supported by Scientific Research Foundation of Gazi University (no. 03/2006-19). The authors declare that they have no conflicts of interest related to this study. This study was financially supported by a Gazi University research grant (no. 03/2006-19).
İlk Sayfa Sayısı
[dc.identifier.startpage]
44
Son Sayfa Sayısı
[dc.identifier.endpage]
51
Dergi Adı
[dc.relation.journal]
JOURNAL OF PERIODONTAL RESEARCH
Dergi Sayısı
[dc.identifier.issue]
1
Dergi Cilt Bilgisi
[dc.identifier.volume]
50
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/jre.12179
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2587
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
13
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
07 Nisan 2024 20:57
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Tıklayınız
levels gingival crevicular periodontitis chronic clinical between correlations probing pocket significantly attachment control higher positive groups plasminogen healthy activator patients tissue destruction ResultsGingival regardless disease periodontal increased detected analyses played compared significant volume Similarly measurements
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