Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer treated with maintenance intravesical Bacillus Calmette-Guerin

Objectives To evaluate the effect of the interval between the initial and second transurethral resection (TUR) on the outcome of patients with high-risk non-muscle-invasive bladder cancer (NMIBC) treated with maintenance intravesical Bacillus Calmette-Guerin (BCG) therapy. Patients and Methods We reviewed the data of patients from 10 centres treated for high-risk NMIBC between 2005 and 2012. Patients without a diagnosis of muscle-invasive cancer on second TUR performed <= 90 days after a complete first TUR, and received at least 1 year of maintenance BCG were included in this study. The interval between first and second TUR in addition to other parameters were recorded. Multivariate logistic regression analysis was used to identify predictors of recurrence and progression. Results In all, 242 patients were included. The mean (SD, range) follow-up was 29.4 (22.2, 12-96) months. The 3-year recurrence-and progression-free survival rates of patients who underwent second TUR between 14 and 42 days and 43-90 days were 73.6% vs 46.2% (P < 0.001) and 89.1% vs 79.1% (P = 0.006), respectively. On multivariate analysis, the interval to second TUR was found to be a predictor of both recurrence [odds ratio (OR) 3.598, 95% confidence interval (CI) 1.885-8.137; P = 0.001] and progression (OR 2.144, 95% CI 1.447-5.137; P = 0.003). Conclusions The interval between first and second TUR should be <= 42 days in order to attain lower recurrence and progression rates. To our knowledge, this is the first study demonstrating the effect of the interval between first and second TUR on patient outcomes.

Yazar Baltaci, Sumer
Bozlu, Murat
Yildirim, Asif
Gokce, Mehmet Ilker
Tinay, Ilker
Aslan, Guven
Can, Cavit
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3321
Tek Biçim Adres 10.1111/bju.13102
Konu Başlıkları non-muscle-invasive bladder cancer
second transurethral resection
Bacillus Calmette-Guerin
maintenance Bacillus Calmette-Guerin
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı BJU INTERNATIONAL
Dergi Cilt Bilgisi 116
Dergi Sayısı 5
Sayfalar 721 - 726
Yayın Yılı 2015
Eser Adı
[dc.title]
Significance of the interval between first and second transurethral resection on recurrence and progression rates in patients with high-risk non-muscle-invasive bladder cancer treated with maintenance intravesical Bacillus Calmette-Guerin
Yazar
[dc.contributor.author]
Baltaci, Sumer
Yazar
[dc.contributor.author]
Bozlu, Murat
Yazar
[dc.contributor.author]
Yildirim, Asif
Yazar
[dc.contributor.author]
Gokce, Mehmet Ilker
Yazar
[dc.contributor.author]
Tinay, Ilker
Yazar
[dc.contributor.author]
Aslan, Guven
Yazar
[dc.contributor.author]
Can, Cavit
Yayın Yılı
[dc.date.issued]
2015
Yayıncı
[dc.publisher]
WILEY-BLACKWELL
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objectives To evaluate the effect of the interval between the initial and second transurethral resection (TUR) on the outcome of patients with high-risk non-muscle-invasive bladder cancer (NMIBC) treated with maintenance intravesical Bacillus Calmette-Guerin (BCG) therapy. Patients and Methods We reviewed the data of patients from 10 centres treated for high-risk NMIBC between 2005 and 2012. Patients without a diagnosis of muscle-invasive cancer on second TUR performed <= 90 days after a complete first TUR, and received at least 1 year of maintenance BCG were included in this study. The interval between first and second TUR in addition to other parameters were recorded. Multivariate logistic regression analysis was used to identify predictors of recurrence and progression. Results In all, 242 patients were included. The mean (SD, range) follow-up was 29.4 (22.2, 12-96) months. The 3-year recurrence-and progression-free survival rates of patients who underwent second TUR between 14 and 42 days and 43-90 days were 73.6% vs 46.2% (P < 0.001) and 89.1% vs 79.1% (P = 0.006), respectively. On multivariate analysis, the interval to second TUR was found to be a predictor of both recurrence [odds ratio (OR) 3.598, 95% confidence interval (CI) 1.885-8.137; P = 0.001] and progression (OR 2.144, 95% CI 1.447-5.137; P = 0.003). Conclusions The interval between first and second TUR should be <= 42 days in order to attain lower recurrence and progression rates. To our knowledge, this is the first study demonstrating the effect of the interval between first and second TUR on patient outcomes.
Açıklama
[dc.description]
WOS: 000362574800013
Açıklama
[dc.description]
PubMed: 25715815
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
non-muscle-invasive bladder cancer
Konu Başlıkları
[dc.subject]
second transurethral resection
Konu Başlıkları
[dc.subject]
Bacillus Calmette-Guerin
Konu Başlıkları
[dc.subject]
maintenance Bacillus Calmette-Guerin
Haklar
[dc.rights]
info:eu-repo/semantics/closedAccess
ISSN
[dc.identifier.issn]
1464-4096
ISSN
[dc.identifier.issn]
1464-410X
İlk Sayfa Sayısı
[dc.identifier.startpage]
721
Son Sayfa Sayısı
[dc.identifier.endpage]
726
Dergi Adı
[dc.relation.journal]
BJU INTERNATIONAL
Dergi Sayısı
[dc.identifier.issue]
5
Dergi Cilt Bilgisi
[dc.identifier.volume]
116
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1111/bju.13102
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3321
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
11
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
18 Şubat 2024 15:35
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second interval between patients recurrence progression effect included analysis maintenance high-risk Patients cancer treated progression-free survival underwent Objectives outcomes patient demonstrating knowledge attain should Conclusions respectively multivariate predictor 3-year confidence recurrence-and identify months therapy without
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