Quality of life and related factors among chronic hepatitis B-infected patients: a multi-center study, Turkey

Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.

Yazar Karacaer, Zehra
Cakir, Banu
Erdem, Hakan
Ugurlu, Kenan
Durmus, Gul
Ince, Nevin Koc
Ozturk, Cinar
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3210
Tek Biçim Adres 10.1186/s12955-016-0557-9
Konu Başlıkları Chronic hepatitis B infection
Quality of life
The Hepatitis B Quality of Life Instrument
Turkey
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı HEALTH AND QUALITY OF LIFE OUTCOMES
Dergi Cilt Bilgisi 14
Sayfalar -
Yayın Yılı 2016
Eser Adı
[dc.title]
Quality of life and related factors among chronic hepatitis B-infected patients: a multi-center study, Turkey
Yazar
[dc.contributor.author]
Karacaer, Zehra
Yazar
[dc.contributor.author]
Cakir, Banu
Yazar
[dc.contributor.author]
Erdem, Hakan
Yazar
[dc.contributor.author]
Ugurlu, Kenan
Yazar
[dc.contributor.author]
Durmus, Gul
Yazar
[dc.contributor.author]
Ince, Nevin Koc
Yazar
[dc.contributor.author]
Ozturk, Cinar
Yayın Yılı
[dc.date.issued]
2016
Yayıncı
[dc.publisher]
BMC
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Background: The aim of this study was to assess health-related quality of life (HRQOL) among chronic hepatitis B (CHB) patients in Turkey and to study related factors. Methods: This multicenter study was carried out between January 01 and April 15, 2015 in Turkey in 57 centers. Adults were enrolled and studied in three groups. Group 1: Inactive HBsAg carriers, Group 2: CHB patients receiving antiviral therapy, Group 3: CHB patients who were neither receiving antiviral therapy nor were inactive HBsAg carriers. Study data was collected by face-to-face interviews using a standardized questionnaire, Short Form-36 (SF-36) and Hepatitis B Quality of Life (HBQOL). Values equivalent to p < 0.05 in analyses were accepted as statistically significant. Results: Four thousand two hundred fifty-seven patients with CHB were included in the study. Two thousand five hundred fifty-nine (60.1 %) of the patients were males. Groups 1, 2 and 3, consisted of 1529 (35.9 %), 1721 (40.4 %) and 1007 (23.7 %) patients, respectively. The highest value of HRQOL was found in inactive HBsAg carriers. We found that total HBQOL score increased when antiviral treatment was used. However, HRQOL of CHB patients varied according to their socio-demographic properties. Regarding total HBQOL score, a higher significant level of HRQOL was determined in inactive HBV patients when matched controls with the associated factors were provided. Conclusions: The HRQOL score of CHB patients was higher than expected and it can be worsen when the disease becomes active. Use of an antiviral therapy can contribute to increasing HRQOL of patients.
Açıklama
[dc.description]
WOS: 000386954300001
Açıklama
[dc.description]
PubMed: 27809934
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
Chronic hepatitis B infection
Konu Başlıkları
[dc.subject]
Quality of life
Konu Başlıkları
[dc.subject]
The Hepatitis B Quality of Life Instrument
Konu Başlıkları
[dc.subject]
Turkey
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1477-7525
Dergi Adı
[dc.relation.journal]
HEALTH AND QUALITY OF LIFE OUTCOMES
Dergi Cilt Bilgisi
[dc.identifier.volume]
14
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1186/s12955-016-0557-9
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3210
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
9
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
15 Nisan 2024 08:03
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Tıklayınız
patients antiviral therapy inactive carriers higher receiving hundred Turkey thousand significant factors included fifty-nine Groups consisted highest respectively Background provided increasing contribute active becomes disease worsen expected Conclusions associated increased controls matched determined Regarding properties
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