Protective effects of vitamin C, alone or in combination with vitamin A, on endotoxin-induced oxidative renal tissue damage in rats

This study was designed to investigate the protective effects of vitamin C and vitamin A on oxidative renal tissue damage. Male Wistar rats were given an intraperitoneal injection of 0.5 ml saline (control) or 0.5 ml solution of lipopolysaccharide (10 mg/kg), which caused endotoxemia. Immediately (within 5 min) after the endotoxin injection, the endotoxemic rats were untreated or treated with intraperitoneal injection of vitamin A (195 mg/kg bw), vitamin C (500 mg/kg bw) or their combination. After 24 hours, tissue and blood samples were obtained for histopathological and biochemical investigation. Endotoxin injection caused renal tissue damage and increased erythrocyte and tissue malondialdehyde (MDA) and serum nitric oxide (NO), urea and creatinine concentrations, but decreased the superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities compared to the parameters of control animals. Treatment with vitamin C or with vitamins C and A significantly decreased the MDA levels and serum NO, urea and creatinine levels, recovered the antioxidant enzyme activities (SOD, GSH-Px and CAT), and prevented the renal tissue damage in endotoxemic rats. In contrast, vitamin A alone did not change the altered parameters except for creatinine levels. Notably, the better effects were observed when vitamins A and C given together. It is concluded that vitamin C treatment, alone or its combination with vitamin A, may be beneficial in preventing endotoxin-induced oxidative renal tissue damage and shows potential for clinical use. - endotoxemia; vitamin A; vitamin C; malondialdehyde; kidney (c) 2005 Tohoku University Medical Press.

Yazar Kanter, M
Coskun, O
Armutcu, F
Uz, YH
Kizilay, G
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/3188
Tek Biçim Adres 10.1620/tjem.206.155
Konu Başlıkları endotoxemia
vitamin A
vitamin C
malondialdehyde
kidney
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Dergi Cilt Bilgisi 206
Dergi Sayısı 2
Sayfalar 155 - 162
Yayın Yılı 2005
Eser Adı
[dc.title]
Protective effects of vitamin C, alone or in combination with vitamin A, on endotoxin-induced oxidative renal tissue damage in rats
Yazar
[dc.contributor.author]
Kanter, M
Yazar
[dc.contributor.author]
Coskun, O
Yazar
[dc.contributor.author]
Armutcu, F
Yazar
[dc.contributor.author]
Uz, YH
Yazar
[dc.contributor.author]
Kizilay, G
Yayın Yılı
[dc.date.issued]
2005
Yayıncı
[dc.publisher]
TOHOKU UNIV MEDICAL PRESS
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
This study was designed to investigate the protective effects of vitamin C and vitamin A on oxidative renal tissue damage. Male Wistar rats were given an intraperitoneal injection of 0.5 ml saline (control) or 0.5 ml solution of lipopolysaccharide (10 mg/kg), which caused endotoxemia. Immediately (within 5 min) after the endotoxin injection, the endotoxemic rats were untreated or treated with intraperitoneal injection of vitamin A (195 mg/kg bw), vitamin C (500 mg/kg bw) or their combination. After 24 hours, tissue and blood samples were obtained for histopathological and biochemical investigation. Endotoxin injection caused renal tissue damage and increased erythrocyte and tissue malondialdehyde (MDA) and serum nitric oxide (NO), urea and creatinine concentrations, but decreased the superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities compared to the parameters of control animals. Treatment with vitamin C or with vitamins C and A significantly decreased the MDA levels and serum NO, urea and creatinine levels, recovered the antioxidant enzyme activities (SOD, GSH-Px and CAT), and prevented the renal tissue damage in endotoxemic rats. In contrast, vitamin A alone did not change the altered parameters except for creatinine levels. Notably, the better effects were observed when vitamins A and C given together. It is concluded that vitamin C treatment, alone or its combination with vitamin A, may be beneficial in preventing endotoxin-induced oxidative renal tissue damage and shows potential for clinical use. - endotoxemia; vitamin A; vitamin C; malondialdehyde; kidney (c) 2005 Tohoku University Medical Press.
Açıklama
[dc.description]
WOS: 000228824400010
Açıklama
[dc.description]
PubMed: 15888972
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
eng
Konu Başlıkları
[dc.subject]
endotoxemia
Konu Başlıkları
[dc.subject]
vitamin A
Konu Başlıkları
[dc.subject]
vitamin C
Konu Başlıkları
[dc.subject]
malondialdehyde
Konu Başlıkları
[dc.subject]
kidney
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
0040-8727
ISSN
[dc.identifier.issn]
1349-3329
İlk Sayfa Sayısı
[dc.identifier.startpage]
155
Son Sayfa Sayısı
[dc.identifier.endpage]
162
Dergi Adı
[dc.relation.journal]
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
Dergi Sayısı
[dc.identifier.issue]
2
Dergi Cilt Bilgisi
[dc.identifier.volume]
206
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.1620/tjem.206.155
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/3188
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
6
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
08 Şubat 2024 06:00
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Tıklayınız
vitamin tissue damage injection creatinine levels oxidative combination activities malondialdehyde endotoxemic parameters endotoxemia caused effects vitamins intraperitoneal decreased recovered significantly enzyme contrast animals GSH-Px Treatment antioxidant change prevented altered endotoxin-induced Medical University Tohoku kidney clinical
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