Increased myocardial energy expenditure in cardiac syndrome X: More work, more pain

Objective: The aim of this study was to assess the myocardial energy expenditure (MEE) in patients with cardiac syndrome X (CSX) and to examine its association with exercise electrocardiogram (ECG) parameters. Methods: A total of 99 patients who underwent coronary angiography and who were diagnosed as having normal coronary arteries were included. The patients were divided into 2 groups based on symptoms and exercise ECG parameters: 56 CSX patients and 43 control patients with a negative stress test. MEE was calculated using transthoracic echocardiography-derived parameters: circumferential end-systolic stress, left ventricular ejection time, and stroke volume. Results: In patients with CSX, the MEE at rest was 28% higher in than the control group (89.2 +/- 36.3 vs. 69.8 +/- 17.2 cal/minute). Correlation analysis revealed a moderately negative correlation between MEE and the Duke treadmill score (DTS) beta:-0.456; p<0.001). Receiver operating characteristic analysis with a cut-off value of 74.6 cal/minute for MEE had a sensitivity of 78.1% and a specificity of 75.3% for the prediction of CSX (area under the curve: 0.872; p<0.001). An extra 1 calorie spent per minute at rest increased the likelihood of CSX by about 86% (odds ratio: 1.863). Conclusion: This study demonstrated that MEE was greater in CSX patients compared with a control group. Increased MEE was determined to be an independent predictor of CSX. DTS was inversely correlated with MEE. Increased MEE may have a crucial role in CSX pathophysiology.

Yazar Cetin, Mehmet Serkan
Cetin, Elif Hande Ozcan
Canpolat, Ugur
Erdol, Mehmet Akif
Aydin, Selahattin
Celebi, Ozlem Ozcan
Temizhan, Ahmet
Yayın Türü Article
Tek Biçim Adres https://hdl.handle.net/20.500.12628/2769
Tek Biçim Adres 10.5543/tkda.2018.76967
Konu Başlıkları Duke score
cardiac syndrome X
myocardial energy expenditure
Koleksiyonlar Araştırma Çıktıları | WoS | Scopus | TR-Dizin | PubMed | SOBİAD
PubMed İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu
Dergi Adı TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
Dergi Cilt Bilgisi 46
Dergi Sayısı 6
Sayfalar 446 - 454
Yayın Yılı 2018
Eser Adı
[dc.title]
Increased myocardial energy expenditure in cardiac syndrome X: More work, more pain
Yazar
[dc.contributor.author]
Cetin, Mehmet Serkan
Yazar
[dc.contributor.author]
Cetin, Elif Hande Ozcan
Yazar
[dc.contributor.author]
Canpolat, Ugur
Yazar
[dc.contributor.author]
Erdol, Mehmet Akif
Yazar
[dc.contributor.author]
Aydin, Selahattin
Yazar
[dc.contributor.author]
Celebi, Ozlem Ozcan
Yazar
[dc.contributor.author]
Temizhan, Ahmet
Yayın Yılı
[dc.date.issued]
2018
Yayıncı
[dc.publisher]
TURKISH SOC CARDIOLOGY
Yayın Türü
[dc.type]
article
Özet
[dc.description.abstract]
Objective: The aim of this study was to assess the myocardial energy expenditure (MEE) in patients with cardiac syndrome X (CSX) and to examine its association with exercise electrocardiogram (ECG) parameters. Methods: A total of 99 patients who underwent coronary angiography and who were diagnosed as having normal coronary arteries were included. The patients were divided into 2 groups based on symptoms and exercise ECG parameters: 56 CSX patients and 43 control patients with a negative stress test. MEE was calculated using transthoracic echocardiography-derived parameters: circumferential end-systolic stress, left ventricular ejection time, and stroke volume. Results: In patients with CSX, the MEE at rest was 28% higher in than the control group (89.2 +/- 36.3 vs. 69.8 +/- 17.2 cal/minute). Correlation analysis revealed a moderately negative correlation between MEE and the Duke treadmill score (DTS) beta:-0.456; p<0.001). Receiver operating characteristic analysis with a cut-off value of 74.6 cal/minute for MEE had a sensitivity of 78.1% and a specificity of 75.3% for the prediction of CSX (area under the curve: 0.872; p<0.001). An extra 1 calorie spent per minute at rest increased the likelihood of CSX by about 86% (odds ratio: 1.863). Conclusion: This study demonstrated that MEE was greater in CSX patients compared with a control group. Increased MEE was determined to be an independent predictor of CSX. DTS was inversely correlated with MEE. Increased MEE may have a crucial role in CSX pathophysiology.
Açıklama
[dc.description]
WOS: 000446496800005
Açıklama
[dc.description]
PubMed: 30204135
Kayıt Giriş Tarihi
[dc.date.accessioned]
2019-12-23
Açık Erişim Tarihi
[dc.date.available]
2019-12-23
Yayın Dili
[dc.language.iso]
tur
Konu Başlıkları
[dc.subject]
Duke score
Konu Başlıkları
[dc.subject]
cardiac syndrome X
Konu Başlıkları
[dc.subject]
myocardial energy expenditure
Haklar
[dc.rights]
info:eu-repo/semantics/openAccess
ISSN
[dc.identifier.issn]
1016-5169
İlk Sayfa Sayısı
[dc.identifier.startpage]
446
Son Sayfa Sayısı
[dc.identifier.endpage]
454
Dergi Adı
[dc.relation.journal]
TURK KARDIYOLOJI DERNEGI ARSIVI-ARCHIVES OF THE TURKISH SOCIETY OF CARDIOLOGY
Dergi Sayısı
[dc.identifier.issue]
6
Dergi Cilt Bilgisi
[dc.identifier.volume]
46
Tek Biçim Adres
[dc.identifier.uri]
https://dx.doi.org/10.5543/tkda.2018.76967
Tek Biçim Adres
[dc.identifier.uri]
https://hdl.handle.net/20.500.12628/2769
Görüntülenme Sayısı ( Şehir )
Görüntülenme Sayısı ( Ülke )
Görüntülenme Sayısı ( Zaman Dağılımı )
Görüntülenme
10
09.12.2022 tarihinden bu yana
İndirme
1
09.12.2022 tarihinden bu yana
Son Erişim Tarihi
06 Şubat 2024 22:11
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Tıklayınız
patients parameters control negative stress analysis coronary Increased exercise characteristic Receiver operating prediction specificity sensitivity cal/minute cut-off Objective predictor greater compared determined independent demonstrated inversely correlated crucial pathophysiology minute calorie increased Conclusion likelihood treadmill between
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